Water Rehydration blunted Vasopressin, Angiotensin II and HSP70 responses to High Environmental Temperature without altering Plasma Osmolality in male Sprague-Dawleys rats
Palavras-chave:
Angiotensin II, HSP70, arginine vasopressin, plasma osmolality, high environmental temperature, rehydration.Resumo
factor. HET alters body fluid balance and elevates plasma osmolality, with consequent release of angiotensin II and arginine vasopressin (AVP) , implicated in the pathophysiology of some forms of hypertension. This study investigated the effect of water rehydration on plasma osmolality, angiotensin II, arginine AVP and heat shock protein (HSP70) during chronic exposure to HET. Eighteen (18) male Sprague-Dawley rats (n = 6/group, 8 weeks old, weight: 90-100g) were either kept in an environmental chamber maintained at a HET (38.5±0.5oC ) 4hrs daily without (H) or with access to water (RH) compared to control rats (C), maintained at room temperature of 25 ±0.5oC oC. Experiment lasted 8 weeks. There was a significant increase in plasma osmolality (P<0.05), fluid balance (P<0.001), angiotensin II (P<0.01), AVP (P<0.001) and HSP 70 (P<0.05) in rats exposed to HET compared to control. However, with water rehydration in rats exposed to similar HET, increases were only noticed in plasma osmolality (P<0.01) and fluid balance (P<0.001), with no significant rise in AVP, angiotensin II and HSP70 compared to control. Meanwhile, AVP was significantly lower (P<0.01) in RH compared to H rats, whereas plasma osmolality, fluid balance, angiotensin II and HSP70 were not significantly different in H and RH rats. The result suggests that water rehydration during prolong exposure to hot environment blunts AVP, angiotensin II and HSP 70 responses to persistent hyperosmolality.
Referências
Agbaraolorunpo, F. M., Oloyo, A. K., Anigbogu, C. N., & Sofola, O. A. (2019). Chronic exposure to high environmental temperature exacerbates sodium retention and worsens the severity of salt-induced hypertension in experimental rats via angiotensin receptor activation. Journal of African Association of Physiological Sciences, 7(2), 109–118.
Agbaraolorunpo, F.M., Oloyo,A.K., Doherty A.A , Said Z.O. and Phillip, O. (2020). Water Intake Attenuates the Hyperglycemic Effect of Chronic Exposure to High Environmental Temperature without Improving Oxidative Stress and Cardiovascular Outcome in Animal Models. Quarterly Journal of Hospital Medicine (In Press)
Akerman, A. P., Tipton, M., Minson, C. T., & Cotter, J. D. (2016). Heat stress and dehydration in adapting for performance: Good, bad, both, or neither? Temperature: Multidisciplinary Biomedical Journal, 3(3), 412–436.
Allan, J. R., & Wilson, C. G. (1971). Influence of acclimatization on sweat sodium concentration. Journal of Applied Physiology, 30(5), 708–712.
Azahan, E., & Sykes, A. H. (1980). The effects of ambient temperature on urinary flow and composition in the fowl. The Journal of Physiology, 304, 389–396. https://doi.org/10.1113/jphysiol.1980.sp013330
Barney, C. C., & Kuhrt, D. M. (2016). Intermittent heat exposure and thirst in rats. Physiological Reports, 4(8).
Birnbaumer M 2000. Vasopressin receptors. Trends Endocrinol Metab 11:406–410.
Beere, H. M. (2005). Death versus survival: Functional interaction between the apoptotic and stress-inducible heat shock protein pathways. Journal of Clinical Investigation, 115(10), 2633–2639.
Burg, M. B., Ferraris, J. D., & Dmitrieva, N. I. (2007). Cellular Response to Hyperosmotic Stresses. Physiological Reviews, 87(4), 1441–1474.
Crandall, C. G., & Wilson, T. E. (2015). Human cardiovascular responses to passive heat stress. Comprehensive Physiology, 5(1), 17–43.
Cuzzo, B., Padala, S. A., & Lappin, S. L. (2020). Vasopressin (Antidiuretic Hormone, ADH). In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK526069/
Fortney S.M, & Miescher E. (1994). Changes in Plasma Volume During Heat Exposure in Young and Older Men. In Fluid Replacement and Heat Stress. National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK231117/
Gagnon, D., Romero, S. A., Ngo, H., Poh, P. Y. S., & Crandall, C. G. (2017). Plasma hyperosmolality improves tolerance to combined heat stress and central hypovolemia in humans. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 312(3), R273–R280.
Gennari, F.J. (1984). Current concepts. Serum osmolality. Uses and limitations. N. Engl. J. Med, 12, 310(2):102-5.
Nose, H., Gary W., Mack G.Z, Shi X., and Nadel. E.R.(1994). Role of Osmolality and Plasma Volume During Rehydration in Humans. National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK231127/
Horowitz, M. (2016). Epigenetics and cytoprotection with heat acclimation. Journal of Applied Physiology, 120(6), 702–710. https://doi.org/10.1152/japplphysiol.00552.2015
Ishizaka, N., Aizawa, T., Ohno, M., Usui, S., Mori, I., Tang, S.-S., Ingelfinger, J. R., Kimura, S., & Nagai, R. (2002). Regulation and Localization of HSP70 and HSP25 in the Kidney of Rats Undergoing Long-Term Administration of Angiotensin II. Hypertension, 39(1), 122–128.
Jiang, B. H., Jiang, G., Zheng, J. Z., Lu, Z., Hunter, T., & Vogt, P. K. (2001). Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research, 12(7), 363–369.
Johnson, R. J., Rodriguez-Iturbe, B., Roncal-Jimenez, C., Lanaspa, M. A., Ishimoto, T., Nakagawa, T., Correa-Rotter, R., Wesseling, C., Bankir, L., & Sanchez-Lozada, L. G. (2014). Hyperosmolarity drives hypertension and CKD -water and salt revisited. Nature Reviews. Nephrology, 10(7), 415–420.
Johnston, C.I.(1985). Vasopressin in circulatory control and hypertension. J Hypertens .3,557–569.
Jolly, C., & Morimoto, R. I. (2000). Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Journal of the National Cancer Institute, 92(19), 1564–1572.
Kampinga, H. H., Hageman, J., Vos, M. J., Kubota, H., Tanguay, R. M., Bruford, E. A., Cheetham, M. E., Chen, B., & Hightower, L. E. (2009). Guidelines for the nomenclature of the human heat shock proteins. Cell Stress & Chaperones, 14(1), 105–111.
Kaya, H., Yücel, O., Ege, M. R., Zorlu, A., Yücel, H., Güneş, H., Ekmekçi, A., & Yılmaz, M. B. (2017). Plasma osmolality predicts mortality in patients with heart failure with reduced ejection fraction. Kardiologia Polska, 75(4), 316–322. 13.
Keller, U., Szinnai, G., Bilz, S., & Berneis, K. (2003). Effects of changes in hydration on protein, glucose and lipid metabolism in man: Impact on health. European Journal of Clinical Nutrition, 57 Suppl 2, S69-74.
Knepper, M.A., Kwon, T.H., Nielsen (2015). Molecular physiology of water balance. N Engl J Med. 372: 1349-58.
Kinsman, B. J., Simmonds, S. S., Browning, K. N., & Stocker, S. D. (2017). Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood Pressure. Hypertension, 69(1), 163–170.
Lucas, R. A. I., Epstein, Y., & Kjellstrom, T. (2014). Excessive occupational heat exposure: A significant ergonomic challenge and health risk for current and future workers. Extreme Physiology & Medicine, 3(1), 1–8.
Martín-Calderón, J. L., Bustos, F., Tuesta-Reina, L. R., Varona, J. M., Caballero, L., & Solano, F. (2015). Choice of the best equation for plasma osmolality calculation: Comparison of fourteen formulae. Clinical Biochemistry, 48(7–8), 529–533.
Meshi, E. B., Kishinhi, S. S., Mamuya, S. H., & Rusibamayila, M. G. (2018). Thermal Exposure and Heat Illness Symptoms among Workers in Mara Gold Mine, Tanzania. Annals of Global Health, 84(3), 360–368.
Maté J and Siegel R 2016). Effect of liquid versus ice slurry ingestion on core temperature during simulated mining conditions. Open J Prev Med.6(6): 21–30.
Matsuhisa A, Taniguchi N, Koshio H, Yatsu T, Tanaka A (2000). Nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 4-(1,4,5,6-tetrahydroimidazo [4,5-d][1]benzoazepine-6-carbonyl) benzanili de derivatives and 4'-(5,6-dihydro-4H-thiazolo[5,4-d][1]benzoazepine-6- carbonyl)benzanilide derivatives. Chem Pharm Bull (Tokyo) 48:21–31.
Morton J.J., Connell J.M., Hughes M.J, Inglis G.C., Wallace E.C.,(1985). The role of plasma osmolality, angiotensin II and dopamine in vasopressin release in man Clin Endocrinol (Oxf). 23(2):129-38.
Nerbass, F. B., Pecoits-Filho, R., Clark, W. F., Sontrop, J. M., McIntyre, C. W., & Moist, L. (2017). Occupational Heat Stress and Kidney Health: From Farms to Factories. Kidney International Reports, 2(6), 998–1008.
Ozsari, S. (2017). Association between Serum Osmolarity and Coronary Artery Stenosis Grade. Journal of Family Medicine, 4(6). https://doi.org/10.26420/jfammed.2017.1128.
Périard, J. D., Racinais, S., & Sawka, M. N. (2015). Adaptations and mechanisms of human heat acclimation: Applications for competitive athletes and sports: Adaptations and mechanisms of heat acclimation. Scandinavian Journal of Medicine & Science in Sports, 25, 20–38.
Quinton, P. M. (2007). Cystic Fibrosis: Lessons from the Sweat Gland. Physiology, 22(3), 212–225.
Rauchman, M. I., Nigam, S. K., Delpire, E., & Gullans, S. R. (1993). An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. American Journal of Physiology-Renal Physiology, 265(3), F416–F424.
Rasouli M (2016). Basic concepts and practical equations on osmolality:biochemical approach. Clin Biochem,49(12), 936-41.
Roh, H.-T., Cho, S.-Y., So, W.-Y., Paik, I.-Y., & Suh, S.-H. (2016). Effects of different fluid replacements on serum HSP70 and lymphocyte DNA damage in college athletes during exercise at high ambient temperatures. Journal of Sport and Health Science, 5(4), 448–455.
Rothstein, A., E.F. Adolph, and J.H. Wills. (1947). Voluntary dehydration. in Physiology of Man in the Desert, E.F. Adolph and Associates, eds. Interscience Publishers, New York. Pp. 254-270
Sawka M.N.,& Coyle E.F.(1999). Influence of body water and blood volume on thermoregulatory and exericse performance in the heat. Exerc. Sport Sci, Rev., 27 ,167-218.
Shah, M. M., & Mandiga, P. (2020). Physiology, Plasma Osmolality and Oncotic Pressure. In .StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK544365/
Shi P, Stocker S.D, Toney G.M.(2007). Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Physiol Regul Integr Comp Physiol 293: R2279–R2289.
Sreedharan, R., & Van Why, S. K. (2016). Heat shock proteins in the kidney. Pediatric Nephrology (Berlin, Germany), 31(10), 1561–1570.
Srivastava, K., Narang, R., Bhatia, J., & Saluja, D. (2016). Expression of Heat Shock Protein 70 Gene and Its Correlation with Inflammatory Markers in Essential Hypertension. PLOS ONE, 11(3), e0151060.
Stocker, S. D., Smith, C. A., Kimbrough, C. M., Stricker, E. M., & Sved, A. F. (2003). Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 284(6), R1521-1528.
Togashi, Y., Shirakawa, J., Okuyama, T., Yamazaki, S., Kyohara, M., Miyazawa, A., Suzuki, T., Hamada, M., & Terauchi, Y. (2016). Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice. Scientific Reports, 6. https://doi.org/10.1038/srep25465.
Verbalis, J. G. (2007). How Does the Brain Sense Osmolality? Journal of the American Society of Nephrology, 18(12), 3056–3059.
Webber R, Franz R & Marx W. A review of local and international heat stress indices, standards and limits with reference to ultra-deep mining. J South African Inst Min Metall. ; 313–324.
Weiss ML, Claassen DE, Hirai T, Kenney MJ. Nonuniform sympathetic nerve responses to intravenous hypertonic saline infusion. J Auton Nerv Syst 57: 109–115, 1996.
Xu, Q., Ganju, L., Fawcett, T. W., & Holbrook, N. J. (1996). Vasopressin-induced heat shock protein expression in renal tubular cells. Laboratory Investigation; a Journal of Technical Methods and Pathology, 74(1), 178–187.
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