Kidney Function Status in Persons Occupationally Exposed to Heavy Metals in Metal Forging Factory in Nnewi, Southeastern Nigeria
Ključne reči:
metal forging, heavy metals, kidney function, kidney, length of service, age, gender, bodymass indexApstrakt
Occupational exposure to heavy metals impacts negatively on human health especially on the functionality of the kidneys. This is a cross sectional study designed to assess the kidney function status in individuals who are occupationally exposed to heavy metals in metal forging factory in Nnewi. A total of 39 apparently healthy individuals in cable manufacturing factory workers aged between 19 and 56 years and 79 control subjects (comprising of 39 control subjects from Nnewi (N) and 40 control subjects from Elele (E) respectively) aged between 18 and 44 years were recruited for the study. 5ml of venous blood sample was collected from each subject for the determination of biochemical parameters (potassium, sodium, chloride, bicarbonate, urea and creatinine levels) using standard laboratory methods. Results revealed that there were significant elevations in the mean concentrations of plasma urea, creatinine, sodium and potassium (p<0.05) with a corresponding significant decrease in the mean plasma chloride and bicarbonate levels in the individuals occupationally exposed to heavy metals in metal forging factory (p<0.05), which suggest an impaired renal function in these individuals.
Reference
Bharti S. Advancement in Forging Process: A Review. Int J Sci Res 2017; 6(12):10-21.13. Amah UK, Madu NK, Ahaneku JE, Ahaneku GI, Onah CE, Onuegbu JA, et al. Evaluation of nephrotoxic effect of lead exposure among automobile repairers in Nnewi Metropolis. Intern J Res Med Sci 2014; 2: 1107-1111.
Anuj Ks. Health hazards of foundries and Forges. Indian Foundry Congress, Pp. 269-272.
Joseph B, Justin SR, Edwin TB, Sankarganesh P, Jeevitha MV, Ajisha SU, et al. Toxic effect of heavy metals on aquatic environment. Int J Biol Chem Sci 2010; 4(4): 939-952.
Roberts JR. Metal toxicity in children. In Training Manual on Pediatric Environmental Health. Emeryville CA: Children's Environmental Health, 1999.
Ernesto S and Ludivina MR. Renal health and the environment: heavy metal nephrotoxicity. Nefrologia 2012; 32(3):275-418.
Marek J. Influence of occupational exposure to organic solvents on kidney function. Int J Occup Med Environ Health 2005; 18(1):5-14.
Sabath E and Robles-Osorio ML. Renal health and the environment: heavy metal nephrotoxicity. Nefrologia 2012; 32: 279−86.
Soderland P, Lovekar S, Weiner DE, Brooks DR and Kaufman JS. Chronic kidney disease associated with environmental toxins and exposures. Adv. Chronic Kidney Dis 2010; 17: 254−64.
Ekong EB, Jaar BG and Weaver VM. Lead-related nephrotoxicity: a review of the epidemiologic evidence. Kidney Int 2006; 70: 2074−2084.
Evans M, Elinder CG. Chronic renal failure from lead: myth or evidence-based fact? Kidney Int 2011; 79: 272−279.
Teresa W, Anna P, Małgorzata T, Tadeusz H, Jan S, Janusz B, et al. Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead. J Occup Health 2015; 57: 91–99.
Weaver VM, Lee BK and Todd AC. Effect modification by delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers. Environ Res 2006; 102: 61−69.
Amah UK, Madu NK, Ahaneku JE, Ahaneku GI, Onah CE, Onuegbu JA, et al. Evaluation of nephrotoxic effect of lead exposure among automobile repairers in Nnewi Metropolis. Intern J Res Med Sci 2014; 2: 1107-1111.
Okpogba AN, Ogbodo EC, Okpogba JC, Analike RA, Amah AK, Odeghe BO, et al. Assessment of kidney function status in chickens (Gallus gallus domestica) in rural (Elele) and urban (Nnewi) Areas. J Medical Sci Clin Res 2018; 6(12):1048-1052.
Okpogba AN, Ogbodo EC, Ugwu EC, Dike CC, Nwoko SO, Amah AK, et al. Assessment of heavy metal levels in blood of metal forging factory workers in Nnewi, Anambra State, Nigeria. J Pharmaceut Biol Sci 2019; 7(1):34-40.
Okpogba AN, Ogbodo EC, Dike CC, Nwoko SO, Ugwu EC, Amah AK, et al. Evaluation of heavy metal levels in blood of cable manufacturing factory workers in Nnewi. International J Clin Biochem Res 2019; 6(3):430-436.
Laron K. Creatinine assay by reaction kinetic approach. Clinica Chimica Acta 1972; 41: 209- 217.
Ochei J and Kolhatkar J. Estimation of plasma urea by Berthelot reaction. In: Medical Laboratory Science, Theory and Practice, 6th reprint, Tata McGraw Hill Publishing Company Limited, New Delhi, 2007, Pp. 114-115.
Dioka CE, Orisakwe OE, Adeniyi FAA and Meludu SC. Liver and renal function tests in artisans occupationally exposed to lead in mechanic village in Nnewi, Nigeria. Int J Environ Res Publ Health 2004; 1:21-25.
Orisakwe OE, Nwachukwu E, Osadolor HB, Afonne OJ and Okocha CE. Liver and kidney function tests amongst paint factory workers in Nkpor, Nigeria. Toxicol Ind Health 2007; 23(3):161-165.
Dongre NN, Suryakar AN, Patil AJ, Rathi DB. Occupational lead exposure in automobile workers in North Karnataka (India): Effect on liver and kidney functions. Al Ameen J Med Sci 2010; 3:284-292.
Zinat A, Hossain M, Bhowmik S, Khanom M, Islam LN and Nabi AHMN. Modulation of renal function indices of the occupationally lead exposed Bangladesh automobile workers. Int J Environ Sci 2012; 3(2):77-87.
Ahmed, N. In Clinical Biochemistry 2nd Edition. Oxford University Press New York, 2011; Pp. 72.
Allen PJ. Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value? Neurosci Biobehavioural 2012; 36 (5): 1442–1462.
Perazella MA and Khan S. Increased mortality in chronic kidney disease: a call to action. Am J Med Sci 2006; 331 (3): 150–153.
Appel LJ, Wright JT and Greene T. Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans. Arch Internal Med 2008; 168 (8): 832–839.
James S and Mitchel G. physiology and disorder of water electrolytes and acid base metabolism. In: Carl AB, Edward R, David E, editors. Tietz Textbook of clinical chemistry and molecular diagnostics. 4th ed. New Delhi: Elsevier Inc; 2006. pp. 1747–1776.
Onuegbu AJ, Olisekodiaka MJ, Nwaba EI, Adeyeye AD and Akinola FFS. Assessment of some renal indices in people occupationally exposed to lead. Toxicol Industr Health 2011; 27(5):475-479.
Babalola OO and Babajide SO. Selected heavy metals and electrolyte levels in blood of workers and residents of industrial communities. Afr J Biochem Res 2009; 3(3):37-40.
Leaf A and Santos RF. Physiologic mechanisms in potassium deficiency. New England J Med 1961; 264:335-354.
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