Immunology Immunometabolism Neuroimmunology Tissue typing Immunotoxicology Infectious diseases Immunotherapy Vaccinology Immuno-oncology Reproductive immunology
Production and Safety of Plasma-Derived Immunoglobulins for Passive Immunization in Nigeria
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Keywords

Plasma-Derived Immunoglobulins
passive immunization
Nigeria

Abstract

Background: Passive immunization with plasma-derived immunoglobulins (PDIs) is crucial for managing infectious diseases in Nigeria, but limited local production and concerns about safety and quality hinder accessibility and affordability.

Aim and Objective: This systematic review was used to evaluate the production and safety of PDIs in Nigeria, identify challenges, and propose improvement strategies. Materials and Methods:  Comprehensive searches were conducted, eligible studies were screened and assessed for quality, and data synthesis and analysis were performed to reveal current production processes, safety profile, and existing gaps.

Results: The findings emphasize the need for enhanced local production, regulatory frameworks, and safety measures to improve access to PDIs in Nigeria. Ethical considerations, participant recruitment strategies, and robust sample collection protocols are essential to safeguard donor and recipient well-being. Collaboration with healthcare facilities, community organizations, and media campaigns facilitate participant identification. Donor eligibility criteria, comprehensive screening, and standardized collection procedures guarantee the quality of collected samples, while strict data protection guidelines maintain participant confidentiality. This systematic approach ensures the safety and suitability of plasma donations for PDI production in Nigeria, contributing to improved accessibility and effectiveness in passive immunization strategies. The work provides an overview of current production processes, technologies, safety profile, and challenges in the production and safety of PDIs. It also proposes strategies to enhance production and safety, identifies research and knowledge gaps, and highlights the importance of collaborative efforts involving government support, infrastructure development, improved regulatory oversight, and knowledge sharing.

Conclusion: Implementing the suggested strategies and conducting further research can improve Nigeria's local production capabilities, ensure the safety of plasma-derived immunoglobulins, and enhance access to these essential therapies.

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