The role of oropharnygeal receptors in thirst perception after dehydration and rehydration
Mots-clés :
Dehydration, Rehydration, Oropharyngeal Receptors, Thirst perception, Drinking, GarglingRésumé
Summary: This study examined the effect of drinking and gargling on thirst perception (TP) in 33 young dehydrated female subjects (18-25yrs), using the visual analogue scale (VAS). Group A subjects drank, while group B gargled the fluid provided - 0.0%, 0.9% and 1.8% NaCl (7.0 ml/kg body weight of fluid). The procedure was alternated two weeks later. All subjects dehydrated for 18 hours prior to the study, and the last 12-hour urine was collected and volume recorded. Subject who provided a 12hr urine volume greater than 400ml was excluded from the study. After recording the baseline TP, and voiding the bladder, drinking/gargling was done within 5 minutes, and the subsequent TPs were recorded at 5 minutes interval for 25 minutes. Blood samples were collected before and at the end of the 30 minutes, when urine volumes were recorded. Drinking (0.0% and 1.8% NaCl) resulted in an initial decrease in thirst perception, which was statistically significant (p<0.05) only up to 10 minutes. Water intake ad libitum (mean ± SEM) at the end of the 30 minutes was statistically significantly lower (p<0.05) only in the group that drank 0.0% NaCl. Gargling on the other hand did not affect TP and water intake throughout the period of study. It can be concluded that drinking, but not gargling reduces thirst perception irrespective of the tonicity of the fluid as earlier reported (Obika et. al., 2009; Salata et. al., 1987). This study suggests that the oropharyngeal receptors for TP are activated by recurrent stimulation by the act of drinking rather than gargling.
Références
Ajayi, OI and Obika, LFO. (2000): Role of oropharyngeal receptors in thirst perception: Abstract No 54 of the 22nd Scientific Conference of the Physiological Society of Nigeria.
Appelgren, BH., Thrasher, TN., Keil, LC and Ramsay, DJ. (1991): Mechanism of drinking induced inhibition of Vasopressin secretion in dehydrated dogs. Am. J. Physiol. Regulatory, Integrative Comp. Physiol., 261: R1226-R1233.
Bayliss, PH and Robertson, GL. (1980): Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function. J. Roy. Med., 73: 255-260.
Bruner, FP. (1993): Pathophysiology of dehydration. Schweiz Rundsch. Med. Prax. 82(29-30): 784-787.
Crammer, JL. (191): Drinking, thirst and water intoxication. Br. J. Psychiatry. 159: 83-89.
Figora, MK and Mack, GW. (1997): Regulation of fluid intake in dehydrated humans: role of oropharyngeal stimulation. Am. J Physiol., 272: 1740-1746. Fitzsimons, JT. (1979): The Physiology of Thirst and Sodium Appetite. Cambridge, UK: Cambridge University Press. 129-222.
Geelen, GI., Keil, LC., Kravik, SE., Wade, CE., Thrasher, TN and Barnes, PR. (1984). Inhibition of plasma Vasopressin by drinking in healthy humans. Am. J. Physiol., 247: R247-R971.
Haung, W., Sved, AF and Striker, EM. (2000): Water
injection provides an early signal inhibitin
osmotically stimulated vasopressin secretion in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 279(3): R756-R760.
Holmes, JH. (1964): Thirst and fluid intake problems in clinical medicine in thirst. Ed: MJ. Waymer, NY. Macmillian. 345-364.
Igbokwe, VU and Obika, LFO. (2008): Thirst perception and dryness of mouth in healthy young adult Nigerians. Afri. Biomed. Res., II 39-46.
Obika, LFO, Idu, FK., George, GO., Ajayi, OI and Mowoe, R.S. (2009): Thirst perception and drinking in euhydrate and dehydrate human subjects. Nig. J. Physiol. Sci., 24(1): 25-32.
Obika, LFO and Mowoe, RS. (1997): Thirst perception in young adult males before and after an oral fluid load and after dehydration. International Union of Physiological Society Congress. Abstract No. 101.01.16.
Robertson, GL. (1991): Disorders of thirst in Man. In: Thirst, physiological and psychological aspects. (eds: DJ. Ramsay and DA. Booth), Springer Verlag, London. Pp. 453-477.
Rolls, BJ., Wood, RJ., Rolls, ET., Lind, HM., Lind, RW and Ledingham, JGG. (1980): Thirst following water deprivation in humans. Am. J. Physiol., 239: R476-R482.
Salata, R.A., Verbalis, JG., Robinson AG. (1987): Cold water stimulation of oropharyngeal receptors in man inhibits release of vasopressin. J. Clin. Endocrinol. Metab., 65(3): 561-7.
Seckl, JR., Williams, DM and Lightman, SL. (1986): Oral hypertonic saline causes transient fall in vasopressin in humans. Am. J. Physiol., 251: R214-R217.
Stricker, EM and Verbalis, JG. (2002): Fluid intake and homeostasis. In: Fundamental Neuroscience (2nd ed.), edited by Squire, LR., Bloom, FE., McConnell, SK., Roberts, JL., Spitzer, NC and Zigmond MJ. Academic Press, San Diego, CA. Pp. 1011-1029.
Thompson, C.J., Selby, P and Bayliss, P.H. (1991): Reproducibility of osmotic and non-osmotic tests on vasopressin secretion in men. Am. J. Physiol. Regul. Integr. Comp. Physiol., 260: 533-539 Zerbe, RL and Robertson, GL. (1983): Osmoregulation of thirst and vasopressin secretion in human subjects: effect of various solutes. Am. J. Physiol. Endocrinol. Metab., 244: E607–E614.
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