Samenvatting
Background: Herbal remedies or food supplements
have increasingly become attractive alternatives to
prevent or treat hyperglycemia and
hypercholesterolemia. The study evaluates the
synergistic effects of Tetracarpidium conophorum
(Tc) nuts and Gongronema latifolium (Gl) leaves
on plasma lipid profile and blood glucose.
Materials and Methods: The study was conducted
on 60 apparently healthy subjects within the age range
of 20-55years. 20 subjects consumed 5g of GI leaves,
20 consumed 75g of Tc nuts and 20 consumed 5g of
GI leaves and 75g of Tc nuts daily for 6 weeks.
Results: The plasma Glucose and Lipid parameters
were analyzed using standard laboratory methods.
Statistically significant reduction was observed in the
level of Plasma fasting blood glucose (FBG), Total
cholesterol (TC), triglycerides (TG), LDL-C and
LDL-C/ HDL-C ratio (P<0.05) of the subjects that
consumed Gl leaves compared with their baseline
values. Similar results were obtained in lipid
parameters of participants that consumed Tc nuts
with a significant increase in their HDL-C level
(P<0.05). Also, subjects that consumed combined Gl
leaves and Tc nuts recorded statistically significant
reduction in the level of plasma FBG and the lipid
parameters with a significant increase in HDL-C level
(P<0.05) compared with their baseline values.
Conclusion: This study concluded that Gl has
hypoglycemic and hypolipidemic effects while Tc has
hypolipidemic effect. Furthermore, the synergistic
hypolipidemic effect of Tc nuts and Gl leaves led to
more significant reduction in the lipids and lipoprotein
values.
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