Determination of Fetal gestational age in singleton pregnancies: Accuracy of ultrasonographic placenta thickness and volume at a Nigerian tertiary Hospital.
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Keywords

Gestational age
placenta thickness
placenta volume
ultrasonography

How to Cite

Adekanmi, A. (2022). Determination of Fetal gestational age in singleton pregnancies: Accuracy of ultrasonographic placenta thickness and volume at a Nigerian tertiary Hospital. African Journal of Biomedical Research, 25(2), 113–119. https://doi.org/10.4314/ajbr.v25i2.1

Abstract

This study was aimed at determining the accuracy of placenta thickness and volume among normal singleton pregnancies in Nigerians. In this prospective cross-sectional study, four hundred and twenty-three (423) consenting healthy singleton pregnant women within 13-40weeks gestational age (GA) with regular menstrual cycle and known last menstrual period were recruited and grouped into 27 groups based on their ultrasound GA. All participants had an obstetric ultrasound, and the main outcome variables were placenta thickness, placenta volume, and ultrasound GA. The data generated were analyzed, and P values ≤ 0.05 were statistically significant in this study. Four hundred and eight (408) normal singleton pregnant women with an average age of 29.6(+/-5) years completed the study. One hundred and seventy-seven (43.4%) were between 26-30 years, while 149(36.5%) were aged 31 years and above. The placenta thickness showed a strong positive linear relationship between GA (Y-axis) and placenta thickness (in mm) (x-axis) with a best-fit line of Y -= -0.19 + 1x. The placenta volume values (X) also had a positive but non-linear relationship with the best fit line equation of Y= 11.88 +0.12X – 0.000102X2 between 13 and 40 weeks of pregnancy. There is a linear relationship between placenta thickness and GA and curvilinear relationships between placenta volume and GA. Routine assessment of placenta thickness and volume could serve as an effective alternative means of dating normal pregnancy in women with unreliable dates of the last menstrual period.

https://doi.org/10.4314/ajbr.v25i2.1
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References

Adeyekun, A. A. (2012): Ultrasound assessment of placental thickness and its correlation with gestational age in normal pregnancy: a preliminary report. Sahel Med J. 2012;15(1):10–5.

Adhikari, R., Deka, P.K., Tayal, A. & Chettri, P.K. (2015): Ultrasonographic Evaluation of Placental Thickness in Normal Singleton Pregnancies for Estimation of Gestation Age. International Journal of Medical Imaging, 3(6):143–147. doi: 10.11648/j.ijmi.20150306.16.

Agwuna, K.K., Eze, C.U., Ukoha, P.O. & Umeh, U.A. (2016): Relationship between Sonographic Placental Thickness and Gestational Age in Normal Singleton Fetuses in Enugu, Southeast Nigeria. Annals of medical and health sciences research, 6(6): 335–340. doi: 10.4103/amhsr.amhsr_457_15.

Algebally, A.M., Yousef, R.R.H., Badr, S.S.H., Al Obeidly, A., Szmigielski, W. & Al Ibrahim, A.A. (2014): The value of ultrasound and magnetic resonance imaging in diagnostics and prediction of morbidity in cases of placenta previa with abnormal placentation. Polish journal of radiology, 79:409–16. doi: 10.12659/PJR.891252.

Azpurua, H. Funai, E., Coraluzzi, L., Doherty, L., Sasson, I., Kliman, M., et al. (2010): Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling. American Journal of Perinatology, 27(2):151–155. doi: 10.1055/s-0029-1234034.

Benacerraf, B. R. (2007): ACR–ACOG–AIUM PRACTICE Guideline for the performance of obstetrical ultrasound. Available at: https://www.pedrad.org/Portals/5/Subspecialties/OB Ultrasound practice guidelines.pdf.

Butt, K., Lim, K., Bly, S., Cargill, Y., Davies, G., Denis, N., et al. (2014): Determination of Gestational Age by Ultrasound. Journal of Obstetrics and Gynaecology Canada, pp. 171–181. doi: 10.1016/S1701-2163(15)30664-2.

Elchalal, U., Ezra, Y., Levi, Y., Bar-Oz, B., Yanai, N., Intrator, O. et al. (2000): Sonographically Thick Placenta: a Marker for Increased Perinatal Risk—a Prospective Cross-sectional Study’, Placenta, 21(2–3):268–272. doi: 10.1053/plac.1999.0466.

Falatah, H. A., Awad, I.A., Abbas, H.Y., Khafaji, M.A., Alsafi, K.G.H. & Jastaniah, S.D. (2014): Accuracy of Ultrasound to Determine Gestational Age in the Third Trimester. Open Journal of Medical Imaging, 04(3):126–132. doi: 10.4236/ojmi.2014.43018.

Fisher, S. J. (2015): Why is placentation abnormal in preeclampsia? American Journal of Obstetrics and Gynecology, 213(4): S115–S122. doi: 10.1016/j.ajog.2015.08.042.

Guyomard, A., Guillarme, M., Ferdynus, C., Franceschini, C., Rousseau, T. & Sagot, P. (2013): Reference ranges and distribution of placental volume by 3D VOCAL analysis between 11weeks and 13weeks 6days. J Ultrasound Med, 32: 1477–1382. doi: 10.7863/ultra.32.8.1477.

Hafner, E., Metzenbauer, M., Hofinger, D., Stonek, F., Schuchter, K., Waldhor, T. et al. (2006): Comparison between the three-dimensional placental volume at 12 weeks and uterine artery impedance/notching at 22 weeks in screening for pregnancy-induced hypertension, pre-eclampsia and fetal growth restriction in a low-risk population. Ultrasound in Obstetrics and Gynecology, 27(6), pp. 652–657. doi: 10.1002/uog.2641.

Higgins, L. E., De Castro, N.R., Addo, N., Wareing, M., Greenwood, S.L., Jones, R.L, et al. (2015): Placental features of late-onset adverse pregnancy outcome’, PLoS ONE, 10(6): e0129117. doi: 10.1371/journal.pone.0129117.

Isakov, K. M. M., Emerson, J.W., Campbell, K.H., Galerneau, F., Anders, A.M., Lee, Y.K., et al. (2018): Estimated Placental Volume and Gestational Age. Am J Perinatol. 35(8):748-757. doi: 10.1055/s-0037-1615285. Epub 2017 Dec 27. PMID: 29281842.

Jain A., Kumar, G., Agarwal, U. & Kharakwal, S. (2001): Placental thickness–a sonographic indicator of gestational age. J of Obst and Gyne of India., 51(3):48–9.

Karthikeyan, T., Subramaniam, R.K., Johnson, W. & Prabhu K. (2012): Placental thickness & its correlation to gestational age & foetal growth parameters- a cross-sectional ultrasonographic study.’, Journal of clinical and diagnostic research : JCDR, 6(10): 1732–5. doi: 10.7860/JCDR/2012/4867.2652.

Kaushal, L., Patil, A. & Kocherla, K. (2015): Evaluation of placental thickness as a sonological indicator for estimation of gestational age of foetus in normal singleton pregnancy. International Journal of Research in Medical Sciences. 333(3):1213–1218. doi: 10.5455/2320-6012.ijrms20150534.

Mathai, B. M., Singla, S.C., Nittala, P.P., Chakravarti, R.J. & Toppo, J.N. (2013): Placental thickness: its correlation with ultrasonographic gestational age in normal and intrauterine growth-retarded pregnancies in the late second and third trimester. Journal of obstetrics and gynaecology of India, 63(4): 230–3. doi: 10.1007/s13224-012-0316-8.

Mayhew, T. M., Wijesekara, J., Baker, P.N. & Ong, S.S. (2004): Morphometric evidence that villous development and fetoplacental angiogenesis are compromised by intrauterine growth restriction but not by pre-eclampsia. Placenta, 25(10): 829–833. doi: 10.1016/j.placenta.2004.04.011.

Metzenbauer, M., Hafner, E., Schuchter, K. & Philipp K. (2002): First-trimester placental volume as a marker for chromosomal anomalies: preliminary results from an unselected population. Ultrasound Obstet Gynecol. 19: 240–242.

Mongelli, M. (2016): Evaluation of Gestation. Medscape, pp. 1–7. Available at: https://emedicine.medscape.com/article/259269-overview.

Mongelli, M., Wilcox, M. & Gardosi, J. (1996): Estimating the date of confinement: ultrasonographic biometry versus certain menstrual dates. American journal of obstetrics and gynecology, 174(1 Pt 1): 278–81.

Naing, L., Winn, T. & Rusli, B. N. (2006): Practical Issues in Calculating the Sample Size for Prevalence Studies. Archives of Orofacial Sciences. 1: 9–14.

Nair, V. V., Nair, S. S. & K, R. (2019): Study of placental location and pregnancy outcome. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 8(4): 1393. doi: 10.18203/2320-1770.ijrcog20191187.

Nowak, P. M., Nardozza, L,.M.M., Araujo Júnior, E., Rolo, L.C., Guimarães Filho, H.A. & Moron, A.F. et al. (2010): Avaliação do volume da placenta no primeiro trimestre de gestação por meio da ultrassonografia tridimensional utilizando o método XI VOCAL. Radiologia Brasileira, 43(2): 81–84. doi: 10.1590/S0100-39842010000200006.

Papageorghiou, A. T., AT, Kemp, B., Stones, W., Ohuma, E.O., Kennedy, S.H., Purwar, M., et al. (2016): Ultrasound-based gestational-age estimation in late pregnancy. Ultrasound in Obstetrics & Gynecology, 48(6):719–726. doi: 10.1002/uog.15894.

Schwartz, N., Wang, E. & Parry, S. (2012): Two-dimensional sonographic placental measurements in the prediction of small-for-gestational-age infants. Ultrasound in Obstetrics and Gynecology, 40(6): 674–679. doi: 10.1002/uog.11136.

Suganya, B., Mallika, A. & Sangeereni, S. (2015): Estimation of Gestational Age By Ultrasonographic Measurement of Placental Thickness. International Journal of Modern Research and Reviews, 3(10): 889–891.

Taipale, P. & Hiilesmaa, V. (2001): Predicting delivery date by ultrasound and last menstrual period in early gestation. Obstetrics and gynecology, 97(2): 189–94.

Titapant, V. & Cherdchoogieat, P. (2014): Nomogram of placental thickness, placental volume and placental vascular indices in healthy pregnant women between 12 and 20 weeks of gestation. J Med Assoc Thai. 97(3):267-73. 97(3): 267–73.

Wolfson, R. N., Zador, I.E., Halvorsen, P., Andrews, B., Sokol, R.J. (1983): Biparietal diameter in premature rupture of membranes: errors in estimating gestational age.’, Journal of clinical ultrasound. 11(7): 371–4.

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