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Abstract
Venous thromboembolism (VTE) is a leading cause of mortality globally, resulting from genetic risk factors and/or acquired risk factors like oral contraceptives, smoking, diabetes, immobilization, cancer, trauma, fracture, and surgical procedures. This study aims to assess the involvement and prevalence of some genetic thrombophilias in Nigerian VTE patients. A total of 107 participants were recruited, comprising 67 individuals with VTE from three tertiary hospitals in Southwest Nigeria and 50 apparently healthy controls. Parameters included the absolute platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer, protein C, protein S, and antithrombin levels. The VTE patients had significantly lower mean platelet counts, protein C and S antigenic concentrations, and protein S activity (p<0.05), with elevated mean PT and D-dimer levels (p<0.05). Protein C antigen and activity levels were reduced in 6.8% and 2.5% of participants, respectively, indicating deficiencies, while protein S antigen and activity were reduced in 1.7% and 0.9%. One (0.9%) participant had reduced antithrombin III level. Seven participants with protein S or C deficiencies experienced recurrent thrombosis. The study identifies type I antithrombin III deficiency and types I and II protein C and S deficiencies as genetic risk factors for VTE. The prolonged PT and elevated D-dimer levels observed in this study challenged the assumption of consistently reduced PT in VTE patients
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