The Aqueous Calyx Extract of Hibiscus sabdariffa Lowers Blood Pressure and Heart Rate via Sympathetic Nervous System Dependent Mechanisms
Trefwoorden:
Hibiscus sabdariffa, Cold pesssor test, Hand grip exercise, Blood pressure, Heart rateSamenvatting
Summary: The antihypertensive effect of Hibiscus sabdariffa (HS) has been validated in animals and man. This study tested the hypothesis that its hypotensive effect may be sympathetically mediated. The cold pressor test (CPT) and handgrip exercise (HGE) were performed in 20 healthy subjects before and after the oral administration of 15mg/Kg HS. The blood pressure (BP) and heart rate (HR) responses were measured digitally. Mean arterial pressure (MAP; taken as representative BP) was calculated. Results are expressed as mean ±SEM. P<0.05 was considered significant. CPT without HS resulted in a significant rise in MAP and HR (111.1±2.1mmHg and 100.8±2.0/min) from the basal values (97.9±1.9mmHg and 87.8±2.1/min; P<0.0001 respectively). In the presence of HS, CPT-induced changes (ΔMAP=10.1±1.7mmHg; ΔHR= 8.4±1.0/min) were significantly reduced compared to its absence (ΔMAP= 13.2±1.2mmHg; ΔHR= 13.8±1.6/min; P<0.0001 respectively). The HGE done without HS also resulted in an increase in MAP and HR (116.3±2.1mmHg and 78.4±1.2/min) from the basal values (94.8±1.6mmHg and 76.1±1.0/min; p<0.0001 respectively). In the presence of HS the HGE-induced changes (ΔMAP= 11.5±1.0mmHg; ΔHR= 3.3±1.0/min) were significantly decreased compared to its absence (ΔMAP=21.4±1.2mmHg; ΔHR= 12.8±2.0/min; P<0.0001 respectively). The CPT and HGE -induced increases in BP and HR suggest Sympathetic nervous system activation. These increases were significantly dampened by HS suggesting, indirectly, that its hypotensive effect may be due to an attenuation of the discharge of the sympathetic nervous system.
Referenties
Adegunloye, B.J, Omoniyi, J.O, Owolabi, O.A, Ajagbona, O.P, Sofola, O.A and Coker, H.A (1996). Mechanisms of blood pressure lowering effects of the calyx extract of Hibiscus sabdariffa in rats. J. African Medicine and Medical Sciences 25: 235-238.
Ajay, M., H.J, Chai, A.M, Mustafa, A.H, Gilani and M.R, Mustafa (2007). Mechanism of antihypertensive effect of Hibiscus sabdariffa L. calyces. J. Ethanopharmacol., 109:338-93
Alarcon-Alonso J, Zamilpa A, Angular F.A, Jimenez-Ferrer (2011). Pharmacological characterization of diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract. J.Ethanopharmarclo., 139:751-6
Allinson L. Hopkins, Marnie G. Lamm, Janet Funk and Cheryl Retenbaugh (2013). Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies. Fitoterapia 85:84-94
Amin and Hamza, (2005). Hepatoprotective effect of Hibiscus sabdariffa on azathioprine induced toxicity in rats. Life Sci., 77:266-278
Blessing W W (1997). The lower brainstem and bodily homeostasis. Oxford University press New York, pp165-268.
Chirinos, J.A, Segers, P, Raina, R, Saif, H, Swillens, A, Emmi, Jr, A.G, Ferrai, V.A, Weigers, S.E and Sutton M.J (2009). Arterial pulsatile haemodynamic local induced by isometric exercise strongly predicts left ventricular mass in hypertension. Am J. Physiol Heart circulation physiol ; 298: 320-330.
Cui J, Wilson T E and Crandall C G (2002). Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans. Am J Physiol Heart Circ Physiol 282: H1717-H1723.
McCraw, D.B., Siegel, W., Stonecipher, H.K., Nutter, D.O., Schlant, R.C. and Hurst J.W. (1972). Response of heart murmurs intensity to isometric (Hand grip) exercise. Br Heart J. 34 (6): 605-10.
Wood, D.L., Sheps, S.G., Elveback, L.R. and Schirger, A. (1984). Cold pressor test as a predictor of Hypertension. Am Heart Association J 6: 301-306
Mckay, D.L., Chen, C-Y.O., Saltzman, E., and Blumberg, J.B., (2009). Hibiscus sabdariffa L. tea (Tisane) lower Blood pressure in Prehypetensive and mildly Hypertensive adults. J. Nutr. 140:298-303
Dempsey J A, Sheel A W, St Croix C M and Morgan B J (2002). Respiratory influences of sympathetic vasomotor outflow in humans. Respir. Phsiol.Neurobiol.130: 3-20.
DiBona G F and Kopp U C (1999). Comprehensive analytical review of the neural control of the kidney in health and disease, notably hypertension. The review argue strongly in favour of the role of renal sympathetic nerve in regulating blood pressure set set-point. Neural control of renal function.Phsiol. Rev 77:75-197.
Delany, E.P., Greaney, J.L., Edwards, D.G., Rose, W.C, Fadel, P.J. and Farquhar, W.B. (2010). Exaggerated sympathetic and pressor responses to hand grip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J. Physiol. Heart and Circulatory Phdiol. Vol 299: H1318-1327
Esler M, Lambert E, Schlain M, and Lambert, Schlain (1996). Chronic activation of the sympathetic nervous system is dominant contributor to systemic hypertension. J. App. Physiol. 109(6):1996-8
Frank, T, Janssen, M and Netzel, M (2005). Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J. Clin. Pharmacol., 45(2):203-210
Furberg C.D, Psaty B.M, Meyer J.V (1995). Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 92(5): 1326-1331.
Guardiola S and Mach N (2004). The therapeutic potential of Hibiscus sabdariffa: a review of the scientific evidence. J. Endocrinol. Nutr. 61(5): 274-295.
Haji-Faraji M and Haji-Tarkhani A (1999). The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J. Ethanopharmacol., 65:231-236
Halter J.B, Stratton J.R and Peifer M.A (1984). Plasma cathecolamines and haemodynamic responses to stress state in man. Acta Physiol Scnad Supply 527: 31-38.
Herrera-Arellano A., Miranda-Sanchez, J., Avica-Castro, P., Herrera-Alvarez, J., Jimnez-Ferrer, J.E., Zamilpa, A., Tortpriello, J. (2007). Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa o patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Medica, 73, 6-12
Hines E A, Brown G E (1936). The cold pressor test for measuring the reactibility of the blood pressure. Am Heart J. 11:1-9
Ines Da-costa-Rocha, Bernd Bonnlaender, Hartwig Sievers, Ivo Pischel and Michael Heinrich (2014). Hibiscus sabdariffa L.- A phytochemical and pharmacological review. J. Food Chemistry 165: 424-443
Ismail A, Ikram E.H.K and Nazri H.S.M (2008). Roselle (Hibiscus sabdariffa L.) nutritional composition, protein quality and health benefits. Food, 2(1), 1-16
Janig W and Habier H J (2003). Neurophysiological analysis of target-related sympathetic pathways- from animal to human: similarities and differences. Acta .Physiol. Scand. 177; 255-274
Jonadet M, J Bastide, P Bastide, B Boyer, A P Carnat and J L Lamaison (1990). In vitro enzyme inhibitory and in vivo cardio-protective activities of Hibiscus sabdariffa. J. Pharmacol.,Belgium 45(2):120-124.
Jian Cui, Urs A, Leuenberger, Cheryl Blaha, Nicholas C. King and Lawrence I. Sinoway (2011). Effect of P2 receptor with Pyridoxine on sympathetic response to exercise pressor reflex in humans. J. Physiol. 589. 3:685-695.
Jing Chen, Dongfery G.U, Cashell E. Jaquish, Chung-Shiuan Chen, Rao D.C, Depei Liu, James E. Hirson, Lee Hamm L, Charles G.U, Paul K. Whelton, Jiang He. (2008). Association between blood pressure responses to cold pressor test and dietary sodium intervention in the Chinese population. Arch Intern Med. 168 (16):1740-1746.
Mckay, D.L, Chen, C.Y.O., Saltzman, E., & Blumberg, J.B. (2009). Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in Pre hypertensive and Mildly hypertensive adults. J. Nutr. 140(2), 298-303
Megan N. Murphy, Masaki Mizuno, Jere H. Mitchell and Scott A. Smith (2011). Cardiovascular regulation by skeletal muscle reflexes in health and disease. Am J Heart Circ Physiol 301(4):1191-1204.
Mojiminiyi, F B O, Adegunloye, B J, Egbeniyi, Y A, Okolo R U (2000). An investigation of the diu-retic effect of an aqueous extract of the petals of Hibiscus sabdariffa. J. Med. Sci., 2:77-80
Mojiminiyi F.B., Dikko M, Muhammad BY, Ojobor PD, Ajagbonna OP, Okolo RU, Igbokwe UV, Mojiminiyi UE, Fagbemi MA, Bello SO, Anga TJ (2007). Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia 78(4) 292-7.
Meunier M T, Villie F, Jonadet M, Batisde J and Batside P (1990). Inhibition of angiotensin I converting enzyme by lavonolic compounds: invitro and in vivo studies. Planta Med., 53:12-15
Obiefuna, P.C.M, Owolabi, O.A, Adegunloye, B. J, Obiefuna, I.P and Sofola, O.A (1993).The petal extract of Hibiscus sabdariffa produces relaxation of isolated rat aorta. Inter J. Pharmacognosy,32: 69-74.
Odigie, I.P, Ettarh, R.R and Adigun, S.A (2003). Chronic administration of aqueous extract of hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J. Ethnophamacol., 86:181-185
Ojeda, D, Jimenez-Ferrer E, Zamipa, A, Herrera-Arellano, A, Tortoriello, J, and Alvarez L (2010). Inhibition of angiotensin converting enzyme activity by the anthocyanins delphinidin and cyaniding-3-sambubiuosides form Hibiscus sabdariffa. J. Ethanopharmacol. 12(1):7-10 Oliver, B., (1960). Medicinal Plants in Nigeria. Nigerian College of Arts, Science and Technology, Ibadan, Nigeria. P. 16.
Onyenekwe P C, Ajani E O, Ameh D A, Gamaniel K S (1990). Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and comparison of its toxicity with that in wistar rats. Cell Biochem. Funct; 17(3):199- 206
Patrice G. Guyenet (2006). The sympathetic control of blood pressure. Nature Reviews Neuroscience,7: 335-346.
Seals, D.R (1990). Sympathetic activation during the cold pressor test: influence of stimulus area. Clin Phsiol 10:123-129.
Vallbo A B, Hagbarth K E, Wallin B G (2004). Microneurography: how the technique developed and its role in the investigation of the sympathetic nervous system. J. Appl. Physiol. 96: 1262-1269
Victor, R.G, Leinbach W.N Jr, Seals D.R, Wallin B.G and Mark A.L (1987). Effects of the cold pressor test on muscle sympathetic nervous activity in humans. Hypertension; 9: 429-436.
Wang C J, Wang J M, Lin W L, Chou F P and Tseng T H (2000). Protective effect of Hibiscus anthocyanis against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol 38(5):411-416.
Downloads
Gepubliceerd
Nummer
Sectie
Licentie
Dit artikel is gelicentieerd onder de Naamsvermelding-NietCommercieel-GeenAfgeleideWerken 4.0 Internationaal licentie.
