Frequency of Hepatitis B and C Co-Infection in Chronic Liver Disease Patients in Calabar, Cross River State, Nigeria
Kata Kunci:
Chronic liver disease, Co-infection, Hepatitis B, Hepatitis C, CalabarAbstrak
Summary: Hepatitis B (HBsAg) and C (HCV) virus are becoming a significant causative factors in the aetiology of chronic liver disease (CLD) worldwide. However, the information on the frequency of HBsAg and HCV virus co-infection in CLD is sparsely reported in Nigeria. In this study, we assessed the frequency of HBsAg and HCV co-infection in CLD. One hundred and eleven subjects aged 19 - 76 years, comprising of 76 CLD patients and 35 apparently healthy subjects without CLD were tested for both HBsAg and HCV virus antibodies using ELISA test kits. Out of the 111 subjects recruited for this study, 76 (68.5%) were CLD patients tested positive for HBsAg and 35 (31.5%) tested negative for HBsAg and served as control. Out of the 76 CLD patients that tested positive for HBsAg, 34 (44.7%) of them also tested positive for HCV, thus, having co-infection with HBV. Incidence of co-infection was highest in those aged 36 - 45 years, and greater in males than females. Among the control group, 4 (11.4%) of the subjects (3 males and 1 female) tested positive for HCV, while 31 (88.6%) subjects (20 males and 11 females) tested negative. This work has shown that the co-infection with HBV and HCV among chronic liver disease patients and the incidence of HCV is high in our locality. Also, some of the supposed apparently healthy subjects in this study tested positive for HCV, hence the need for improving the awareness of this virus. It is therefore necessary to give immunization and test for HBsAg and HCV in both rural and urban areas.
Referensi
Abiodun P. O., Agumadu U. H. (2012). Hepatitis B virus infection in patients with homozygous sickle cell disease, Need for intervention. Anna Biomed Sci. 1: 79-87.
Bwogi J., Braka F., Makumbi I., Mishra V., Bakamutumaho B., Nanyunja M. A., Opio A., Downing R., Biryahwaho B., Lewis R. F. (2009). Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey. African Health Sciences, 9(2):98 - 108.
Clement C. J., Sodeinde O., Odeola H. A., Ayoola E. A. (1990). Survey of Hepatitis B vaccine joins fight against Pandemic disease. World Health Forum. 11: 165-8.
Crawford J. M. (1999). Viral hepatitis. In Robbins Pathologic basis of disease. 7th ed. India. 701-706.
Dusheiko G. M., Khakoo S. S., Grellier L. (1999). A national approach to the management of Hepatitis C infection. British Medical Journal. 312: 351-364.
Edemariam T. (2004). The liver. In: Principles of medicine in Africa. Parry e, Geoffrey R, Mabey D, gill G (eds). 3rd ed. Cambridge University Press; p.991-1007.
Inyang-Etoh P. C., Eyo G. O., Philip-Ephraim E. E. (2014). Occurrence of hepatitis ‘B’ and ‘C’ among patients on antiretroviral drug therapy (ART) in a treatment centre in Calabar, Nigeria. IJMMS. 6(6): 158-160.
Maheshwari A., Ray S., Thuluvath P. J. (2008). Acute hepatitis C. Lancet. 372(9635): 321332.
Mazhar S. B., Ziauddin S. A., Muhammad I. S. (2013). Frequency and Clinical presentations of hepatitis B and C virus co-infection in tertiary care hospital, Rawal Medical Journal, 38(1): 11 - 14.
Okpokam D. C., Kooffreh-Ada M., Okhormhe Z. A., Akpabio E. N., Akpotuzor J. O., Nna V. U. (2015). Hepatitis D Virus in Chronic Liver Disease Patients with Hepatitis B Surface Antigen in University of Calabar Teaching Hospital, Calabar, Nigeria. British Journal of Medicine and Medical Research. 6(3): 312-318
Ola S. O., Odaibo G. N., Olaleye O. D. (2004). HCV and HBV infections in Nigerian patients with Liver cirrhosis and Hepatocellular carcinoma. Nig Q J Hospital Med, 14: 3 - 4.
Olubuyide I. O., Aliyu B., Olaleye O. A., Ola S. O., Olawuyi F., Malabu U. H. (1997). Hepatitis B and C virus and Hepatocellular carcinoma. Trans R Soc Trop Med Hyg, 91(1): 38 - 41.
Omuenu C. E., Ndububa D. A., Nnabuchi V. C. (2012). Prevalence of Hepatitis B Surface Antigen and anti-hepatitis C antibodies in chronic liver disease patients in a Nigerian Teaching Hospital. Journal of Medical Research and Practice, 2: 23- 6
Otegbayo J. A., Olusegun I. A., Anyinwu S. N., OLadejo O. L., Ndububa D. A., Nwsu M. N., Odike M. A., Agbakwuru E. A., Akere A., Ola S. O., Soyemi M. O, Okonkwo U. C. (2012). Characteristics of inflammatory blood disease in three tertiary health centers in Southern Nigeria. West African Journal of Medicine. 31(1): 28033.
Peter H., Tokyo O. (2000). Hepatitis B and its incubation period. http/www/scientistsmagT ech.org.
Ryan K. J., Ray C. G. (2004). Shenis Medical
Microbiology 4th ed. McGraw Hill; 551-552.
Shehu M. Y. (2002). Prevalence of hepatitis C virus antibodies among patients with chronic liver disease at the Jos University Teaching Hospital. A dissertation submitted to the West African College of Physicians in partial fulfilment of the requirements for the award of Fellowship of the college.
World Health Organization (WHO), (2000). Hepatitis B. http://www.none who.inf/inf- fs/en/fact204.html
World Health Organisation (WHO) (2011). “Hepatitis C”. June 2011.
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