Alcohol Herbal Beverage and Ethanol Consumption in High-Fat Diet fed Rats Exacerbates Blood pressure, Insulin Resistance, dyslipidemia, and Cardio-hepatic inflammation
DOI:
https://doi.org/10.54548/چکیده
The current study was designed to investigate the outcome of alcohol herbal beverages and ethanol consumption in high-fat diet-induced cardiometabolic syndrome (indices) in rats. The study consists of eight groups of 10 rats per cage. Groups 1-4 were fed a standard normal diet while groups 5-8 were initially fed on HFD for 3 weeks prior to alcohol herbal beverage (AHB), ethanol (EtOH) administration and then continually for 6 weeks. Our result showed that rats fed with HFD showed significant increase in weight gain, relative adipose weight, systolic blood pressure, diastolic and mean arterial blood pressure, oral glucose tolerance test, insulin and insulin resistance, dramatically increased TNF-a, IL-6, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triglyceride, total cholesterol and decrease superoxide dismutase, reduce glutathione, catalase in the liver and heart tissue. Meanwhile, alcohol herbal beverage (AHB), and ethanol (EtOH) administration alongside ND or HFD feeding showed similar effects and also indicated histopathology alteration. In conclusion, alcoholic herbal beverages and ethanol consumption in normal or high-fat diet feeding may cause impaired glucose tolerance, lipogenesis, elevated insulin level, insulin resistance, liver and heart tissue structural damage marked by elevated oxido-nitrosative stress, and inflammation.
مراجع
Adewunmi, H. O., & Agwo, E. O. (2023). Assessment of alcohol consumption and nutritional status of commercial drivers in selected Oshodi terminal in Lagos state. Federal Polytechnic Ilaro Journal of Pure And Applied Sciences, 5(1).
Aguas-Ayesa, M., Yárnoz-Esquiroz, P., Olazarán, L., Perdomo, C. M., García-Goñi, M., Andrada, P., & Frühbeck, G. (2023). Evaluation of Dietary and Alcohol Drinking Patterns in Patients with Excess Body Weight in a Spanish Cohort: Impact on Cardiometabolic Risk Factors. Nutrients, 15(22), 4824.
Ajayi, A. M., Arasi, R. O., Ben-Azu, B., Godson, J. C., Umukoro, S., & Aderibigbe, A. O. (2020). Nigerian Psychoactive Alcoholic Herbal Mixture Impacts Behavioural Performance and Caused Brain Biochemical and Histopathological Alterations in Mice. African Journal of Biomedical Research, 23(2), 255-265.
Ajayi, A. M., Melete, J., Ben‐Azu, B., & Umukoro, S. (2023). Aggressive‐like behaviour and neurocognitive impairment in alcohol herbal mixture‐fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex. J Biochem and Mol Toxicol, 37(2), e23252. PMID: 36281499
Araújo SP, Juvanhol LL, Bressan J, Hermsdorff HHM. Triglyceride glucose index: A new biomarker in predicting cardiovascular risk. Prev Med Rep. 2022 Aug 24;29:101941. doi: 10.1016/j.pmedr.2022.101941. PMID: 36161140; PMCID: PMC9502283.
Bakhtiyari M, Kazemian E, Kabir K, Hadaegh F, Aghajanian S, Mardi P, Ghahfarokhi NT, Ghanbari A, Mansournia MA, Azizi F. Contribution of obesity and cardiometabolic risk factors in developing cardiovascular disease: a population-based cohort study. Sci Rep. 2022 Jan 28;12(1):1544. doi: 10.1038/s41598-022-05536-w. PMID: 35091663; PMCID: PMC8799723.
Brinkman TM, Lown EA, Li C, Tonning Olsson I, Marchak JG, Stuber ML, Vuotto S, Srivastava D, Nathan PC, Leisenring WM, Armstrong GT, Robison LL, Krull KR. Alcohol consumption behaviors and neurocognitive dysfunction and emotional distress in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Addiction. 2019 Feb;114(2):226-235. doi: 10.1111/add.14439. Epub 2018 Oct 19. PMID: 30194889; PMCID: PMC6421854.
Cai X, Hu J, Wen W, Wang J, Wang M, Liu S, Zhu Q, Hong J, Dang Y, Yao X, Sun L. Associations of the cardiometabolic index with the risk of cardiovascular disease in patients with hypertension and obstructive sleep apnea: results of a longitudinal cohort study. Oxidative Medicine and Cellular Longevity. 2022;2022(1):4914791.
Chaar LJ, Coelho A, Silva NM, Festuccia WL, Antunes VR. High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice. Physiol Rep. 2016 Jun;4(11):e12811. doi: 10.14814/phy2.12811. PMID: 27273815; PMCID: PMC4908489.
Demori I, Voci A, Fugassa E, Burlando B. Combined effects of high-fat diet and ethanol induce oxidative stress in rat liver. Alcohol. 2006 Nov 1;40(3):185-91.
Devarbhavi H, Asrani SK, Arab JP, Nartey YA, Pose E, Kamath PS. Global burden of liver disease: 2023 update. Journal of hepatology. 2023 Aug 1;79(2):516-37.
Duprez D, Toleuova A. Prehypertension and the cardiometabolic syndrome: pathological and clinical consequences. Expert Rev Cardiovasc Ther. 2013 Dec;11(12):1725-33. doi: 10.1586/14779072.2013.857272. PMID: 24215200.
Ekmekcioglu C, Wallner P, Kundi M, Weisz U, Haas W, Hutter HP. Red meat, diseases, and healthy alternatives: A critical review. Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):247-261. doi: 10.1080/10408398.2016.1158148. Epub 2017 Jun 28. PMID: 27128451.
Fernández-Solà, J. (2020). The Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy. Nutrients, 12(2), 572. doi:10.3390/nu12020572
Friedewald, W. T., Levy, R. I., & Friedrickson, D. S. (1972). Estimation of the concentration of low- density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499–502.
Galavi A, Hosseinzadeh H, Razavi BM. The effects of Allium cepa L.(onion) and its active constituents on metabolic syndrome: A review. Iranian journal of basic medical sciences. 2021 Jan;24(1):3.
Gopal T, Ai W, Casey CA, Donohue TM Jr, Saraswathi V. A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease. Alcohol Clin Exp Res. 2021 Oct;45(10):1927-1939. doi: 10.1111/acer.14698. Epub 2021 Sep 23. PMID: 34558087; PMCID: PMC9153937.
Góth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta. 1991 Feb 15;196(2-3):143-51. doi: 10.1016/0009-8981(91)90067-m. PMID: 2029780.
Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982). Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Analytical biochemistry, 126(1), 131-138. doi:10.1016/0003-2697(82)90118-x
Hakucho A, Liu J, Liu X, Fujimiya T. Carvedilol improves ethanol-induced liver injury via modifying the interaction between oxidative stress and sympathetic hyperactivity in rats. Hepatol Res. 2014 May;44(5):560-70. doi: 10.1111/hepr.12143. Epub 2013 May 22. PMID: 23607506.
Hamano M, Ezaki H, Kiso S, Furuta K, Egawa M, Kizu T, Chatani N, Kamada Y, Yoshida Y, Takehara T. Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. J Gastroenterol. 2014 Feb;49(2):305-16. doi: 10.1007/s00535-013-0780-7. Epub 2013 Mar 20. PMID: 23512345; PMCID: PMC3925298.
Huang QH, Wu X, Chen XH, Wu JZ, Su ZR, Liang JL, Li YC, Lai XP, Chen JN, Liu YH. Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation. RSC Adv. 2018 Jul 5;8(43):24399-24410. doi: 10.1039/c8ra02422g. Erratum in: RSC Adv. 2018 Aug 14;8(50):28745. PMID: 35539211; PMCID: PMC9082196.
Huang QH, Wu X, Chen XH, Wu JZ, Su ZR, Liang JL, Li YC, Lai XP, Chen JN, Liu YH. Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation. RSC Adv. 2018 Jul 5;8(43):24399-24410. doi: 10.1039/c8ra02422g. Erratum in: RSC Adv. 2018 Aug 14;8(50):28745. PMID: 35539211; PMCID: PMC9082196.
Husain K, Ansari RA, Ferder L. Alcohol-induced hypertension: Mechanism and prevention. World J Cardiol. 2014 May 26;6(5):245-52. doi: 10.4330/wjc.v6.i5.245. PMID: 24891935; PMCID: PMC4038773.
Ibraheem, O., & Adigun, R. O. (2018). A review of alcoholic bitters proliferation in Nigeria: A friendly multifaceted killer looming across the nation. Journal of Medicine and Biomedical Research, 17(1-2), 63-79.
Ikewuchi, J. C., & Ikewuchi, C. C. (2009). Alteration of plasma lipid profiles and atherogenic indices by Stachytarpheta jamaicensis L (Vahl). Biokemistri, 21, 71–77. https://doi.org/10.4314/biokem.v21i2.56473
Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974;11(3):151-69. doi: 10.1159/000136485. PMID: 4831804.
Kehinde OS, Adegoke AE. Taking alcohol by deception: an analysis of ethanol concentration of "paraga" an alcoholic herbal mixture in Nigeria. BMC Res Notes. 2012 Mar 6;5:127. doi: 10.1186/1756-0500-5-127. PMID: 22394987; PMCID: PMC3315750.
Kehinde OS, Adegoke AE. Taking alcohol by deception: an analysis of ethanol concentration of" paraga" an alcoholic herbal mixture in Nigeria. BMC research notes. 2012 Dec;5:1-5.
Kehinde, O. S., & Adegoke, A. E. (2012). Taking alcohol by deception: an analysis of ethanol concentration of" paraga" an alcoholic herbal mixture in Nigeria. BMC research notes, 5, 1-5.
Khan AR, Salama AH, Aleem Z, Alfakeer H, Alnemr L, Shareef AMM. The Promising Frontier of Cardiometabolic Syndrome: A New Paradigm in Cardiology. Cureus. 2023 Sep 19;15(9):e45542. doi: 10.7759/cureus.45542. PMID: 37868505; PMCID: PMC10586230.
Kim JY, Lee DY, Lee YJ, Park KJ, Kim KH, Kim JW, Kim WH. Chronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunction. World journal of biological chemistry. 2015 Feb 2;6(1):1.
Liu J. Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver. World J Gastroenterol. 2014 Oct 28;20(40):14672-85. doi: 10.3748/wjg.v20.i40.14672. PMID: 25356030; PMCID: PMC4209533.
Martínez-Francés V, Rivera D, Obon C, Alcaraz F, Ríos S. Medicinal Plants in Traditional Herbal Wines and Liquors in the East of Spain and the Balearic Islands. Front Pharmacol. 2021 Sep 29;12:713414. doi: 10.3389/fphar.2021.713414. PMID: 34658855; PMCID: PMC8513779.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9. doi: 10.1007/BF00280883. PMID: 3899825.
Medina-Remón A, Kirwan R, Lamuela-Raventós RM, Estruch R. Dietary patterns and the risk of obesity, type 2 diabetes mellitus, cardiovascular diseases, asthma, and neurodegenerative diseases. Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):262-296. doi: 10.1080/10408398.2016.1158690. Epub 2017 Jul 5. PMID: 27127938.
Minzer S, Losno RA, Casas R. The Effect of Alcohol on Cardiovascular Risk Factors: Is There New Information? Nutrients. 2020 Mar 27;12(4):912. doi: 10.3390/nu12040912. PMID: 32230720; PMCID: PMC7230699.
Minzer S, Losno RA, Casas R. The Effect of Alcohol on Cardiovascular Risk Factors: Is There New Information? Nutrients. 2020 Mar 27;12(4):912. doi: 10.3390/nu12040912. PMID: 32230720; PMCID: PMC7230699.
Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972 May 25;247(10):3170-5. PMID: 4623845.
Moreno-Fernández S, Garcés-Rimón M, Vera G, Astier J, Landrier JF, Miguel M. High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model. Nutrients. 2018 Oct 14;10(10):1502. doi: 10.3390/nu10101502. PMID: 30322196; PMCID: PMC6213024.
Ndisang JF, Rastogi S. Cardiometabolic diseases and related complications: current status and future perspective. Biomed Res Int. 2013;2013:467682. doi: 10.1155/2013/467682. Epub 2013 Oct 9. PMID: 24224165; PMCID: PMC3809929.
Nelson, E. U. E., & Uko, I. J. (2019). Ethnomedical beliefs and utilization of alcohol herbal remedy for malaria in south-coastal Nigeria. International quarterly of community health education, 39(2), 119-126.
Nikrad N, Hosseini B, Pakmehr A, Tousi AZ, Ardekani AM, Farhangi MA, Akhavan-Sigari R. Dietary carbohydrate quality index (CQI), cardio-metabolic risk factors and insulin resistance among adults with obesity. BMC Endocr Disord. 2023 Aug 11;23(1):171. doi: 10.1186/s12902-023-01420-4. PMID: 37568117; PMCID: PMC10416415.
Nwokediuko SC, Osuala PC, Uduma UV, Alaneme AK, Onwuka CC, Mesigo C. Pattern of liver disease admissions in a Nigerian tertiary hospital. Nigerian Journal of Clinical Practice. 2013 Sep 10;16(3):339-42.
Osna NA, Donohue Jr TM, Kharbanda KK. Alcoholic liver disease: pathogenesis and current management. Alcohol research: current reviews. 2017;38(2):147.
Pallavi M, Ramesh CK, Siddesha JM, Krishna V, Kavitha GC, Nethravathi AM, Sameera Parveen, Anil Kumar KM. Anti-hyperlipidemic effects of citrus fruit peel extracts against high fat diet-induced hyperlipidemia in rats. Int. J. Res. Pharm. Sci., 2021, 12(3), 2226-2232.
Pan ZG, An XS. SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation. Biochem Biophys Res Commun. 2018 Apr 6;498(3):416-423. doi: 10.1016/j.bbrc.2018.02.115. Epub 2018 Feb 15. PMID: 29454967.
Panchal SK, Poudyal H, Iyer A, Nazer R, Alam A, Diwan V, Kauter K, Sernia C, Campbell F, Ward L, Gobe G, Fenning A, Brown L. High-carbohydrate high-fat diet–induced metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol. 2011 Jan;57(1):51-64. doi: 10.1097/FJC.0b013e3181feb90a.
Piano MR. Alcohol's Effects on the Cardiovascular System. Alcohol Res. 2017;38(2):219-241. PMID: 28988575; PMCID: PMC5513687.
Qi, Y., & Wang, X. (2023). The role of gut microbiota in high-fat-diet-induced diabetes: lessons from animal models and humans. Nutrients, 15(4), 922.
Salete-Granado, D., Carbonell, C., Puertas-Miranda, D., Vega-Rodríguez, V. J., García-Macia, M., Herrero, A. B., & Marcos, M. (2023). Autophagy, oxidative stress, and alcoholic liver disease: a systematic review and potential clinical applications. Antioxidants, 12(7), 1425.
Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008 Dec;6(4):299-304. doi: 10.1089/met.2008.0034. PMID: 19067533.
Sun YE, Wang W, Qin J. Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis. Medicine. 2018 May 1;97(18):e0255.
Tan BL, Norhaizan ME. Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients. 2019 Oct 25;11(11):2579. doi: 10.3390/nu11112579. PMID: 31731503; PMCID: PMC6893649.
Tasic I, Lovic D. Hypertension and cardiometabolic disease. Front Biosci (Schol Ed). 2018 Jan 1;10(1):166-174. doi: 10.2741/s506. PMID: 28930524.
Ting PS, Lin WT, Huang CK, Lin HY, Tseng TS, Chen PH. Exclusive liquor and cocktail consumption is associated with at-risk fibrosis among nonheavy alcohol users with metabolic dysfunction-associated steatotic liver disease. Alcohol Clin Exp Res (Hoboken). 2024 Jan;48(1):88-97. doi: 10.1111/acer.15220. Epub 2023 Nov 29. PMID: 38206286; PMCID: PMC10786214.
Tsuru H, Osaka M, Hiraoka Y, Yoshida M. HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse. Sci Rep. 2020 Oct 16;10(1):17593. doi: 10.1038/s41598-020-74617-5. PMID: 33067533; PMCID: PMC7568538.
Wang Y, Branicky R, Noë A, Hekimi S. Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. J Cell Biol. 2018 Jun 4;217(6):1915-1928. doi: 10.1083/jcb.201708007. Epub 2018 Apr 18. PMID: 29669742; PMCID: PMC5987716.
Wang Y, Seitz HK, Wang XD. Moderate alcohol consumption aggravates high‐fat diet induced steatohepatitis in rats. Alcoholism: Clinical and Experimental Research. 2010 Mar;34(3):567-73.
Wang, W., Liu, Y., Li, Y., Luo, B., Lin, Z., Chen, K., & Liu, Y. (2023). Dietary patterns and cardiometabolic health: Clinical evidence and mechanism. MedComm, 4(1), e212.
White, A. M. (2020). Gender differences in the epidemiology of alcohol use and related harms in the United States. Alcohol research: current reviews, 40(2).
World Health Organization (2024), Alcohol (Accessed date 11 April, 2024). https://www.who.int/news-room/fact-sheets/detail/alcohol
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