Anti-Inflammatory Potentials of Anacardium Occidentale L. Nut Methanol Extract in Wistar Rats

نویسندگان

  • Gbenga Olayinka Neurosciences and Oral Physiology Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • Oyetola Oyebanjo Department of Physiology, Faculty of Basic Medical Sciences, Babcock University, Ilishan-Remo
  • Mujeedat Olubori Department of Physiology, Igbinedion University, Okada
  • Abayomi Ajayi Neuropharmacology Unit, Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • Samuel Onasanwo Neurosciences and Oral Physiology Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria

DOI:

https://doi.org/10.54548/

چکیده

The Anacardium occidentale nut is increasingly gaining attention due to its economic, nutritional value and biological properties. This study is aimed at evaluating the anti-inflammatory potential of Anacardium occidentale nut Methanol extract (AOME) in carrageenan-induced paw oedema and the carrageenan-induced air pouch models of inflammation. AOME (200 mg/kg) significantly (p<0.05) inhibited carrageenan-induced increase in paw volume and increase in paw size, respectively, at 5 hours post-carrageenan injection. In the carrageenan induced air pouch inflammation model, 200 mg/kg AOME significantly (P<0.05) reduced exudate volume, Total leucocyte count, Neutrophil cell count, Monocyte count and Lymphocyte count.  200 mg/kg AOME also reduced significantly MDA, Nitrite, TNF-α, IL-6, and significantly increased GSH and catalase levels. Anacardium occidentale nuts showed anti-inflammatory effects through reduction in lipid peroxidation and TNF-α and IL-6 activity, alongside amelioration of oxidative stress.

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چاپ شده

2026-06-30

شماره

نوع مقاله

Full Length Research Articles

نحوه استناد به مقاله

Anti-Inflammatory Potentials of Anacardium Occidentale L. Nut Methanol Extract in Wistar Rats. (2026). Nigerian Journal of Physiological Sciences, 41(1), 75-82. https://doi.org/10.54548/

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