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Abstract
Parkinson’s disease (PD) and dementia with Lewy bodies have several commonalities including neurochemical, morphological and clinical features as well as widespread of cortical and limbic α-synuclein and amyloid-β pathologies. Thus, we evaluated the action of hesperidin on α-synuclein and amyloid-β-induced neurodegeneration in Drosophila melanogaster. The disease causing human Aβ peptide or α- synuclein was expressed respectively, in Elav-GAL4 (pan-neuronally) and dopaminergic neurons (ddc-GAL4) using the UAS-GAL4 system. Flies were either grown on food media supplemented with or without hesperidin (HSD) (1, 5, or 10mM). Behavioral assays were carried to investigate the effect of treatment on fecundity, larval motility, climbing ability and lifespan. Aβ>Elav or α-syn>DDC caused significant decrease in fecundity, larva contraction, motility, survival rate, and climbing activities in flies indicative of neurodegeneration. However, supplementation of flies’ media with hesperidin (1mM, 5mM and 10mM) showed a dose-dependent increase in the number of line crosses in the egg laying, larva motility, climbing activity in comparison with flies grown on food media only. Conversely, supplementation of fly feed with HSD caused no significant change in lifespan. Findings from this experiment showed that hesperidin could be a potential neuroprotective agent in the amelioration of PD and AD pathogenesis
References
ABELIOVICH, A. & GITLER, A. D. 2016. Defects in trafficking bridge Parkinson's disease pathology and genetics. Nature, 539, 207-216.
ABOLAJI, A. O., BABALOLA, O. V., ADEGOKE, A. K. & FAROMBI, E. O. 2017. Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster. Environmental toxicology and pharmacology, 55, 202-207.
ADELOYE, D., AUTA, A., EZEJIMOFOR, M., OYEDOKUN, A., HARHAY, M. O., RUDAN, I. & CHAN, K. Y. 2019. Prevalence of dementia in Nigeria: a systematic review of the evidence. Journal of global health reports, 3.
ALBERS, M. W., GILMORE, G. C., KAYE, J., MURPHY, C., WINGFIELD, A., BENNETT, D. A., BOXER, A. L., BUCHMAN, A. S., CRUICKSHANKS, K. J. & DEVANAND, D. P. 2015. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's & Dementia, 11, 70-98.
ANTUNES, M. S., GOES, A. T., BOEIRA, S. P., PRIGOL, M. & JESSE, C. R. 2014. Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice. Nutrition, 30, 1415-1422.
ARUMUGAM, M., JAYAPALAN, J. J., ABDUL-RAHMAN, P. S., HASHIM, O. H. & SUBRAMANIAN, P. 2018. Effect of hesperidin on the temporal regulation of redox homeostasis in clock mutant (Cryb) of Drosophila melanogaster. Biological Rhythm Research, 49, 93-102.
BREDESEN, D. E., RAO, R. V. & MEHLEN, P. 2006. Cell death in the nervous system. Nature, 443, 796-802.
BUCHMAN, A. S. & BENNETT, D. A. 2011. Loss of motor function in preclinical Alzheimer’s disease. Expert review of neurotherapeutics, 11, 665-676.
CHAKRABORTY, R., VEPURI, V., MHATRE, S. D., PADDOCK, B. E., MILLER, S., MICHELSON, S. J., DELVADIA, R., DESAI, A., VINOKUR, M. & MELICHAREK, D. J. 2011. Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. PloS one, 6, e20799.
CHATTOPADHYAY, D., JAMES, J., ROY, D., SEN, S., CHATTERJEE, R. & THIRUMURUGAN, K. 2015. Effect of semolina-jaggery diet on survival and development of Drosophila melanogaster. Fly, 9, 16-21.
DAVIS, R. C., MARSDEN, I. T., MALONEY, M. T., MINAMIDE, L. S., PODLISNY, M., SELKOE, D. J. & BAMBURG, J. R. 2011. Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Molecular neurodegeneration, 6, 10.
DOS SANTOS MORAES, W. A., POYARES, D. R., GUILLEMINAULT, C., RAMOS, L. R., BERTOLUCCI, P. H. F. & TUFIK, S. 2006. The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study. Sleep, 29, 199-205.
DUFFY, J. B. 2002. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. genesis, 34, 1-15.
HAJIALYANI, M., HOSEIN FARZAEI, M., ECHEVERRÍA, J., NABAVI, S. M., URIARTE, E. & SOBARZO-SÁNCHEZ, E. 2019. Hesperidin as a neuroprotective agent: a review of animal and clinical evidence. Molecules, 24, 648.
HÄRLEIN, J., DASSEN, T., HALFENS, R. J. & HEINZE, C. 2009. Fall risk factors in older people with dementia or cognitive impairment: a systematic review. Journal of advanced nursing, 65, 922-933.
HASHIMOTO, M., IMAMURA, T., TANIMUKAI, S., KAZUI, H. & MORI, E. 2000. Urinary incontinence: an unrecognised adverse effect with donepezil. The Lancet, 356, 568.
HOLSCHNEIDER, D. P., GUO, Y., ROCH, M., NORMAN, K. M. & SCREMIN, O. U. 2011. Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury. Journal of Neurotrauma, 28, 1909-1919.
HOZAYEN, W. G. 2012. Effect of hesperidin and rutin on doxorubicin induced testicular toxicity in male rats. Int J Food Nutr Sci, 1, 31-42.
IRIZARRY, M. C., GROWDON, W., GOMEZ-ISLA, T., NEWELL, K., GEORGE, J. M., CLAYTON, D. F. & HYMAN, B. T. 1998. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity. Journal of Neuropathology & Experimental Neurology, 57, 334-337.
JAYAPALAN, J. J., SUBRAMANIAN, P., KANI, A., HIJI, J., NAJJAR, S. G., ABDUL‐RAHMAN, P. S. & HASHIM, O. H. 2020. Hesperidin modulates the rhythmic proteomic profiling in Drosophila melanogaster under oxidative stress. Archives of Insect Biochemistry and Physiology, e21738.
JEONG, S. 2017. Molecular and cellular basis of neurodegeneration in Alzheimer’s disease. Molecules and cells, 40, 613.
JUSTIN-THENMOZHI, A., BHARATHI, M. D., KIRUTHIKA, R., MANIVASAGAM, T., BORAH, A. & ESSA, M. M. 2018. Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT/GSK-3β pathway by hesperidin in wistar rats. Neurotoxicity research, 34, 463-476.
LEKOUBOU, A., ECHOUFFO-TCHEUGUI, J. B. & KENGNE, A. P. 2014. Epidemiology of neurodegenerative diseases in sub-Saharan Africa: a systematic review. BMC public health, 14, 653.
MHATRE, S. D., SATYASI, V., KILLEN, M., PADDOCK, B. E., MOIR, R. D., SAUNDERS, A. J. & MARENDA, D. R. 2014. Synaptic abnormalities in a Drosophila model of Alzheimer’s disease. Disease models & mechanisms, 7, 373-385.
MINTER, M. R., TAYLOR, J. M. & CRACK, P. J. 2016. The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease. Journal of neurochemistry, 136, 457-474.
NAGHAVI, M. H. 2018. " APP" reciating the complexity of HIV-induced neurodegenerative diseases. PLoS pathogens, 14, e1007309.
NICHOLS, C. D., BECNEL, J. & PANDEY, U. B. 2012. Methods to assay Drosophila behavior. JoVE (Journal of Visualized Experiments), e3795.
OLAYINKA, O. O. & MBUYI, N. N. 2014. Epidemiology of dementia among the elderly in Sub-Saharan Africa. International Journal of Alzheimer’s disease, 2014.
ORIÁ, R. B., DE ALMEIDA, J. Z., MOREIRA, C. N., GUERRANT, R. L. & FIGUEIREDO, J. R. 2020. Apolipoprotein E Effects on Mammalian Ovarian Steroidogenesis and Human Fertility. Trends in Endocrinology & Metabolism.
PEDRINOLLA, A., VENTURELLI, M., FONTE, C., MUNARI, D., BENETTI, M. V., RUDI, D., TAMBURIN, S., MUTI, E., ZANOLLA, L. & SMANIA, N. 2018. Exercise training on locomotion in patients with Alzheimer’s disease: a feasibility study. Journal of Alzheimer's Disease, 61, 1599-1609.
POETINI, M., ARAUJO, S., TRINDADE, D. P. M., BORTOLOTTO, V., MEICHTRY, L., POLET, D. A. F., JESSE, C., KUNZ, S. & PRIGOL, M. 2018a. Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease. Chemico-biological interactions, 279, 177.
POETINI, M. R., ARAUJO, S. M., DE PAULA, M. T., BORTOLOTTO, V. C., MEICHTRY, L. B., DE ALMEIDA, F. P., JESSE, C. R., KUNZ, S. N. & PRIGOL, M. 2018b. Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease. Chemico-Biological Interactions, 279, 177-186.
REITZ, C. & MAYEUX, R. 2014. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochemical pharmacology, 88, 640-651.
SANTOS, G., GIRALDEZ-ALVAREZ, L. D., ÁVILA-RODRIGUEZ, M., CAPANI, F., GALEMBECK, E., NETO, A. G., BARRETO, G. E. & ANDRADE, B. 2016. SUR1 receptor interaction with hesperidin and linarin predicts possible mechanisms of action of Valeriana officinalis in Parkinson. Frontiers in aging neuroscience, 8, 97.
SHALTIEL-KARYO, R., DAVIDI, D., MENUCHIN, Y., FRENKEL-PINTER, M., MARCUS-KALISH, M., RINGO, J., GAZIT, E. & SEGAL, D. 2012. A novel, sensitive assay for behavioral defects in Parkinson's disease model Drosophila. Parkinson’s disease, 2012.
SHINOTOH, H., NAMBA, H., YAMAGUCHI, M., FUKUSHI, K., NAGATSUKA, S. I., IYO, M., ASAHINA, M., HATTORI, T., TANADA, S. & IRIE, T. 1999. Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy. Annals of neurology, 46, 62-69.
SMITH, G. A., HEUER, A., DUNNETT, S. B. & LANE, E. L. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia. Behavioural brain research, 226, 281-292.
WENK, G. L. 2003. Neuropathologic changes in Alzheimer's disease. The Journal of Clinical Psychiatry.
WHO 2019. Dementia fact sheet. . May 14, 2019. ed.: World Health Organisation.
WIRDEFELDT, K., ADAMI, H.-O., COLE, P., TRICHOPOULOS, D. & MANDEL, J. 2011. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. European Journal Of Epidemiology, 26, 1.
WYSS-CORAY, T. 2016. Ageing, neurodegeneration and brain rejuvenation. Nature, 539, 180-186.
ZHOU, L., TAN, S., SHAN, Y.-L., WANG, Y.-G., CAI, W., HUANG, X.-H., LIAO, X.-Y., LI, H.-Y., ZHANG, L. & ZHANG, B.-J. 2016. Baicalein improves behavioral dysfunction induced by Alzheimer’s disease in rats. Neuropsychiatric Disease And Treatment, 12, 3145.
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