Exercise attenuates the effect of high salt intake on the cardiovascular function, oxygen saturation,lung function and renal function of young men
DOI:
https://doi.org/10.54548/njps.v39i2.6Abstract
Abstract
Coronary heart disease (CAD), respiratory disease, and early-onset renal failure, which until recently were only common in high-income countries, are now the dominant source of morbidity and mortality among young Nigerian adults. However, epidemiological studies have suggested the possibility of high dietary salt intake and physical inactivity as behavioral factors that may be responsible for these growing trend. Therefore, the purpose of this study was to determine the influence of elevated salt intake and physical activity and inactivity on the pulmonary function, cardiovascular, and renal function of young Nigerian men. Methods and materials: A total of 20 subjects, comprising 10 non-exercising young men (control) and 10 exercising young men, participated in the study after obtaining an approval from the ethical committee of the animal and human research bioethics department. Lung function, oxygen saturation, blood pressure, urine volume, urine pH, and urine Na+ and K+ concentration were measured under resting conditions before and after five days of 200mmol of salt loads in both groups. The data was analyzed using the SPSS Statistics software package Version 19. The unpaired t-test was used to calculate the P-value across the groups. The paired t-test was used to calculate the p-value within the groups. Statistical significance was reached when P < 0.05. Results: Salt loading had no significant effect on the pulmonary function of the control subjects. However, salt loading worsened the pulmonary function values of the exercising subjects, with FEV1, FVC, and PEFR decreased significantly by -0.05 ± 0.05 L, -0.003 ± 0.01 L, and -20.20 ± 7.11 L/min, respectively, without affecting oxygen saturation (SPO2) and FEV1%. Salt loading caused a greater increase in the blood pressure parameters of the non-exercising subjects, with systolic pressure, diastolic pressure, mean arterial pressure, and pulse pressure significantly increased by 18.00 ± 2.04 mmHg, 11.90 ± 1.52 mmHg, 13.97 ± 1.98 mmHg, and 6.20 ± 0.24 mmHg, respectively. In summary, exercising subjects eliminate salt loads more effectively than the non-exercising subjects to reduce salt retention. This might be as a result of the trigger of several pathophysiological mechanisms that alter vital body functions such as respiratory function, renal function, and cardiovascular functions.
Keywords: Oxygen Saturation, pro-inflammatory cytokines, Hyperinsulinemia, angiotensin-2, and Nitric oxide.
Literaturhinweise
References
• Abramowitz S, Leiner C, Lewis W. A. And Small J. (1965). Vital Capacity in the Negroid. Am. Rev. Resp. Dis. 92: 287-292.
• Adegoke OA & Arogundade O (2002). The effect of chronic exercise on lung function and basal metabolic rate in some Nigerian athletes. African journal of biomedical research 5:9-11.
• Aderele W. 1. & Oduwole O. (1983). Peak Expiratory Flow Role in Healthy School Children. Nig. J Paed. 10: 45-55.
• Aderele W. L & Oduwole O. (1983). Pulmonary Function in Symptomatic Asthmatic Children. Nig. J Paed. 10 (3): 73-80.
• Akita S, Sacks FM, Svetkey LP, Conlin PR, Kimura G:For the DASH sodium trial collaborative research group (2003).Effects of the dietary approach to stop hypertension (dash)diet on the pressure natriuresis relationship. Hypertension 42..
• Alderman MH, Madhavan S, Cohen H (1995). Low urinary sodium is associated with greater risk of myocardial infarction among treated hypertensive men. Hypertension Vol 25, page 1144-1152.
• Ali A. A. & Vahala K. V. (1991). Some Observation of Peak Expiratory Flow Rate in Normal School Children in Northern Nigeria: West African J Med. 10 (2): 141-144.
• America Heart Association, 2010 Dietary Guideline “2010 Dietary Guideline; American Heart Association, 2009.
• American heart Association (2010). Dietary guideline “Dietary guideline” American heart Association. 2009.
• Anderson .S (1985).Exercise induced asthma; the state of the art. Chest; vol 87; s191-s195.
• Ataman S, Cooper R, Rotimi C, Sotimehin B (1996). Standardization of blood pressure in an international collaborative study. European journal of clinical investigation; 49; 869-877.
• Australia: Better Health Channel: Betterhealth.vic.goo.all, 2011.
• Bankir L, Bochund M, Maillard M, Bovet P, Gabriel and burner M (2008).Night time blood pressure and nocturnal dipping are associated with daytime urinary sodium excretion in African subjects. Hypertension 51;891-898.
• Barnes, P. J. (1989). Our Changing Understanding of Asthma. Resp. Med 83 (Supplement): 17-23.
• Baumgart P. (1991). Circadian rhythm of blood pressure; internal and external trigger. ‘chronobiol int 8;444-450.
• Bech JN, Nielsen CB, Pedersen EB. (1996). Effect of systemic NO synthesis inhibition on renal plasma flow, glomerular filtration rate, urine Na+ concentration and vasoactive hormones in healthy humans. Am j. physio;f845-f851.
• Ben-dov LZ & Bursztyn M (2011).Can salt sensitivity of blood pressure be assessed without changing salt diet? Hypertension; 57;156-157.
• Benedetti RG& Linas SL (1985). Effect of potassium depletion on two- kidney, one clip renovascular hypertension in rat. Kidney int 28:621-625.
• Bens M, Chassin C, Vandevalle A (2006) .Regulation of sodium chloride transport in the renal collecting duct:lessons from cultured cells.pflugger Arch;453;133-146.
• Besterman JM, May WS, Levine H (1985). Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. American journal of biology. vol 260, page1155-1159.
• Binder, R. E., Mitchell, C. An. Schoenberg, J. B. And Heuhuys, A. (1976): Lung Function among Black And White Children Am. Rev. 'Dis. 114: 955-959.
• Bouhuys, A. (1977). The Physiology of Breathing. Gruned and Stratton, New York.
• Bragula E, Dela Sierra D, Antonio MT(2001). Endothelial dysfunction in salt sensitive essential hypertension. Hypertension vol 37, page 444-448.
• Bragulat E, De ja sierra A, Antonio MT and Coca A (2001). Endothelial dysfunction in salt sensitive essential hypertension. Hypertension; 37; 444-448.
• Braith RW, Welsh MA, Feigenbaum MS, Kluess WA, Pepire CJ (1999). Neuroendocrine activation in heart failure is modified by Endurance exercise training. Journal of American College of Cardiology.
• Burney P, Nield J & Twort C (1989).The effect of changing dietary sodium on the bronchial response to histamine; THORAX , vol 44, page 36-41.
• Burney P.G (1995). The Origins of Obstructive airway disease: a role for diet? Am. J. Respir. Crit. Care Med. 151:1292-1293, 1995.
• Burney, P.A (1987) diet rich in sodium may potentiate asthma: epidemiologic evidence for a new hypothesis. Chest 91:143-148.
• Caldwell J.H, Schaller KL, Lasher RS (2000) “Sodium channel Nacl. 6 is localized at nodes of ranvier, dendrites and synapses” Proceedings from the National Academy of Science; Vol 97 (10) Page 5616 – 5620,
• Chen J, Gu D, Huang J. (2009).metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in china; a dietary intervention study. Lancet vol 373 (9666):829-835.
• Coetzee A. and Swanepoal C (1990): The Oxyhemo- globin dissociation curve before, during and after cardiac surgery. Scandinavian Journal of clinical and Laboratory Investigation. vol 203, Page 149 – 153, .
• Coleman, A. E. (1972). Comparison of Weekly Strength Changes Following Isometric and Isotonic Training. J Sports Med. 12: 26-29.
• Coruzzi P, Parati G, Brambilla L, brambilla V, Gualerzi M, Novarini A, Castiglioni P and jeunemaitre X. (2005).Effect of salt sensitivity bon neural cardiovascular regulation of essential hypertension.Hypertension;46;1321-1326.
• Cournand A, Richards D. M. & Darlying R. C. (1939): Graphic Tracings of Respiration on Study of Pulmonary Disease. Am Rev. Tuberc. 40: 487- 516.
• Cowley AW.(1992).long term control of arterial blood pressure. Physiol Rev 72; 231-300.
• Debetto P, Floriani M, Carpenedo F (1984).Exchange in cardiac sacrolemmal vesicles by amiloride; LIFE SCIENCE,VOL40,page 1523-30
• Dietary Guidelines for Americans 2010; US Department for Agriculture and Us department of health and human service, 2012.
• Dosman 1. Et Al (1975). The Use of Helium - Oxygen Mixture during Maximal Expiratory Flow to Demonstrate Obstruction of Small Airways in Smokers. J Clin. Invest. 55: 1090.
• Dumler F (2008). “Dietary Sodium Intake and arterial Blood pressure” Journal of renal nutrition, Vol 19 page 57 – 60,
• Eggleston P (1979).Guidelines for methodology of exercise challenges testing of asthmatics. Journal, allergy of clinical immunology, vol 64,642-64.
• Ekwueme B. M. (1993) An Essay approach To Ingneouw Petrology (1st ed.) Pp . 29-30: 97-98.
• Elebute E. A. & Femi-Pearse E. (1971). Ventilatory Functions In Healthy Nigerian Adults; Clin Sci 41: 202-211. dietary salt loading rats. Blood pressure 13 (5):316- 320.
• Elias S, Dina T, Sofola O.A.(2004).Carotid chemoreceptor reflex following dietary salt loading in rats. Blood pressure 13 (5):316-320.
• Elliot P, Stammler J, Nicholas R, Dyner A, Stamler R , kestleloot H and Marmot M(1996);INTERSALT REVISITED ;further analyses of 24hr sodium excretion and blood pressure within and across populations ;INTERSALT cooperative research group; BMJ 312;1249-1251.
• EL-sayed H and Hainsworth R (1996).Salt supplementation increases plasma volume and orthostatic tolerance in patients with unexplained syncope; heart 75;134-140.
• End of War on Salt; Scientific American, 2011.
• European salt producers Association. EU.salt.com, 2011.
• Feng JA, Perry G, Mori T, Harashi T, OParil S and Chen YF (2003).Pressure –Independent enhancement of cardiac hypertrophy in atrial natriuretic peptide deficient mice. clinical experimental pharmacology –physiology 30;343-349.
• Floreami .M & Luciani. S (1984). Amiloride relationship between cardiac effects and inhibition of Na+/Ca+ exchanger; European journal of pharmacol, vol 105 .Page 317-322.
• Food Safe Authority of Ireland: Salt and Health Review of the Scientific Evidence and recommendations for public policy in Ireland Page 12.
• Franco V & Oparil S (2006).Salt sensitivity, a determinant of blood pressure, cardiovascular disease and survival. Journal of American college of disease; 25; 245s-255s.
• Frisbee JC and Lombard JH (1999). Hypertension compromise arteriolar in rats cremaster muscle, microvascular respiration.vol 57,page 273-283.
• Fukunda M, Goto B, Kimura G (2006).Hypothesis on renal mechanism of non- dipper pattern of circadian blood pressure rhythm. Med. Hypotheses 67; 802-806.
• Garcia-estan J & roman RJ.(1989). Role of renal interstitial hydrostatic pressure in the pressure diuresis response. Am j physiol 216; F63-F70 .
• Garcia-estan J, Navairo J, Atucha NM, Quesada T,Romero JC,Cachofeiro V,lahera V.(1996).Chronic effect of nitric oxide and prostaglandin inhibition on pressure diuresis and natriuresis in rats. Kidney int 49:5141-5143.
• Gill JM & Malkova D (2006). physical activity ,fitness and cardiovascular disease risk in adults:interactions with insulin resistance and obesity. Clin sci (London);110:409- 425.
• Gill JM.(2007).physical activity, cardiorespiratory fitness and insulin resistance :a short update. Current opinion lipidology: 18(1):47-52.
• Gilson, 1. C. And Hugh - Jones P. (1949): The Measurement of Total Lung Volume and Breathing Capacity. Clin. Sci. 7: 85-216.
• Goldspink G, Howells K. F, Ward P. S. (1976) Effect of Exercise on Muscle Fibre. In: Joke E, and R. L. And Stobey H (Eds). Pp.l03-113.
• Graudal NA, Galloe A, Garred P (1998).Effect of sodium restriction on blood pressure, renin, Aldosterone, catecholamines, cholesterols and triacylglyceride, a meta- analysis. JAMA 279; 1383-1391.
• Green HJ, Jones S, baal- burnett M, Fraser M(1991). Early adaptation s in blood substrates, metabolities and hormones to prolong exercise training in man.Can Z ;69:1222-1229.
• Gregg, I. And Nunn, A. G. (1973): Peak Expiratory Flow in Normal Subjects. Brit. Med. J. 3: 228-284.
• Grobee DE and Hoffman A. (1986).Does sodium restriction lowers blood pressure? BMJ 293; 27-29.
• Guarasci GR & Kline RL (1996).Pressure natriuresis, following acute and chronic inhibition of NOS in rats .Am j physiol 270 :R469- R478.
• Guyton AC, Coleman TG, Cowley AW, Schoel KW, Manning RD, Norman RA.(1972).Arterial pressure regulation ,overriding dominance of the kidney in long term regulation and in hypertension. Am j Med 52: 584-594.
• Harold MC (2004). On food and cooking: Scribner 2nd Edition Page 642.
• Harre E. S, Price P. D, Ayrey R. B, Toop L. 1, Marting R, Town G. 1. (1997). Respiratory Effects of Air Pollution In Chronic Obstructive. Pulmonary Disease; A Three Month Prospective Study. Thorax 52 (12); 1040-1044.
• Haugen E & Nath KA (1999). The involvement of oxidative stress in the progression of renal injury. blood purif 17:58-65.
• He FJ & Macgregor GA (2002).Effect of modest salt reduction on blood pressure: a meta-anaysis of randomized trials: implications for public health. J. human hypertension 16:761-770.
• He FJ & Macgregor GA (2007). Salt, blood pressure and cardiovascular disease. Curr opin cardiol; 22;298-305.
• Health Canada “Health Living Sodium: Healthy Living Health Canada, 2008.
• Higashi Y, Sasaki S, Nakagama K (2001) Sodium chloride loading does not alter endothelium dependent vasodilation of fore arm vasculature in either salt sensitive and salt resistance patient with essential hypertension, hypertension research vol 24,page 711-716.
• Hollenbeck C& Reaven GM (1987) .Variation s in insulin stimulated glucose uptake in individuals with normal glucose tolerance .j clin endocrinol metab ;64:1169-1173.
• Holloszy JO & Coyle EF (1984). Adaptations of skeletal muscle to endurance exercise and their metabolic consequences .j Appl Physiol;56:831-846.
• Holloszy JO. (2005).Exercise –induced increase in muscle insulin sensitivity. J appl physiol ;99:338-343.
• Hoppeler H & fluck M (2003). Plasticity of skeletal muscle mitochondria: Structure and function. Med sci sport exerc; 35:95-104.
• Howley JA (2002). Adaptations of skeletal muscle to prolonged, intense endurance training.Clin Exp pharmaco physiol; 29:218-222.
• Hsiung yen, Hua-yang J, Rong sheu y, Mei lee Y, An-ding Y. (1995).Chronic exercise enhances endothelial mediated dilation in spontaneously hypertensive rats. Life sci 57;2205-2213.
• Husted RF, Takahashi T, strokes JB. (1996).interstitial medullary collecting duct cell (IMCD) cultured from dahl sensitive rats absorbs more Na+ than dahl resistant rats. American journal of physiology. vol 271:F1029-F1036.
• Hutcheson IR & Griffith TM (1991).Release of endothelium-derived relaxing factor is modulated both by frog and amplitude of pulsatile flow. Am j physiol 261:H257- H262.
• Hutchinson 1. (1845). On The Capacity Of The Lungs And The Respiratory Movements With The View Of Establishing A Precise And Easy Method of Detecting Disease By The Spirometer. Lancet: 630-632.
• Institute for Health Metrics and Evaluation (IHME) diet high in sodium. Global Burden of Disease; 2019 (https://www.healthdata.org/results/gbd_summaries/2019/diet-high-in-sodium-level-3-risk).
• International Cordex Alimentarius Standard for Food Grade Salt (ICASFS), 2011.
• INTERSALT (1988)’An international study on electrolyte excretion and blood pressure results of the 24hr urinary sodium and potassium excreation.BMJ,297;311-328.
• Jackson FL (1991).An evolutionary perspective on salt hypertension and human genetic variability. Hypertension ; 17;1-129-1-132.
• Jacquez & John (1979) Respiratory Physiology Mcgraw Hill. Page 156 – 175,
• Jacquish CE, Rao DC, Hixxon JE, Chen JC, Duan X, Huang JF, Chen CS, Kelly TN, Bazzano LA, and whelton PK; for the gensalt collaborative research group(2009).Gender difference in blood pressure responses to dietary sodium intervention in the Gensalt study.journal of hypertension;27;48-54.
• Jaja E.I., And Ojo, G. O. (1983): Peak Expiratory Flow Rate In Young Adults, Nig. J Physiol. Sci. 1, 2 : 24.
• Jaja S. 1. (1989): Ventilatory Function in Adult Nigerians Nig. J. Physiol. Sci. 5 (2): 96-10l.
• Jaja S. 1. And Ojo G. O. (1985). Prediction Equations for FVC and FEVI in Healthy Adult Nigerians: In Comparison with Other Negroid Formulae. Nig Qt .J. Hosp. Med. 3(2): 33-37.
• Jaja S. 1. And Ojo, G. O. (1983). Peak Flow Rate in Adult Nigerian. Nig. J. Physiol. Sci. 1 (2): 24-30.
• Jaja S. I and Ogunberu, A. A. (1996). Peak Expiratory Flow Rate in Nigerian Aged Between 50 and 80 Years: Nig. Qt. J. Hosp. Med. 6(4): 305-308.
• Jaja S. I. (1994): A Review Of Studies on Respiration in Normal Nigerian Children, Adults and Athletes: Nig. Qt. J Med. 5: 2.
• Jaja S. I. And Awogbemi B. (1999). Recovery of Ventilation Pulse Rate and Blood Pressure after Exercise in Asthmatics. J. Med. And Med. Sci. 1(2): 99- 105.
• Jaja S. I. And Fagbenro A. O. (1994): Peak Expiratory Flow Rate in Nigerian School Children. Afr. J Med. Medical Sci. (In Press.).
• Jaja S. I. And Fagbenro A. O. (1995) Expiratory Flow Rate in Nigerians School Children. Afr. J Med Med. Sci. 24: 379-384.
• Jaja, S. I, Opesanwo O, Mojiminiyi F. B. O. And Kehinde M. O. (2000). Lung Function, Haemoglobin and Irreversibly Sickled Cells in Sickle Cell Patients. West Afr. J Med 19(3): 225-229.
• James V & Livingstone (2005). Agriculture and soil pollution: New research Nova publishers, page 45, .
• Johansen Z. M. And Erasmus L. D. (1968). Clinical Spirometry in Normal Bantu: Am. R. Resp. Dis. 97: 585-597.
• Johnson Z. M. And Erasmus L. D. (1968). Clinical Spirometer in Normal Bantu Children. Am Review Of Resp. Dis. 97: 585-590.
• Kaplan NM (2000). The dietary guidelines for sodium ; should we shake it up/ no. American journal of clinical nutrition.
• Kawasaki T, Delen CS, Barter FC, smith H (1978).The effect of high sodium and low sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension.American journal of medicine;vol 64;193-19.
• Khalid RA (2006).Molecular mechanism linking salt to hypertension; New molecular target adds more spice. American journal of physiology, vol 290;R-509-R-513.
• Khanan AA, Sachideva U, Gulesia R, Deepak KK.(1996). Study of pulmonary and autonomic function of asthma patients after yoga training. indian j.physiol pharmacol;40 (4) 313-324.
• Kim and Kohong (1975). Multiple Regression And Analysis; Subprogram Regression In Statistical Package for the Social Sci. E. Nic Hn. H. Huyl C. B., Jenkins 1. G, Steinbrenner K. And Bent D. H. McGraw-Hill Book Company, N. Y. Pp. 315-332 .
• Kimora G (2008).Kidney and circadian blood pressure rhythm. Hypertension; 54; 827-828.
• Kimura G, and Brenner BM (1997.implication s of the linear pressure natriuresis relationship and importance of sodium sensitivity in hypertension. journal Hypertension;15;1055-1061.
• Kocks P. 1. And Scott, D. D. (1990). Ammonia Salt Health Hazard in Work Place. South Afr. Med. J. 78: 45.
• Lavoisier A. L (1789). Traite Elementaire De Chime
• Leff A. R. & Schumacker P. T. (1993). Respiratory Physiology: Basics and Applications. WB Saunders Company, Philadelphia. Pp 123-133.
• Leiner G, Abromowitz S, Lewis 1. N, Small M. J, Stenly U. (1963). Standard Value for Normal Subjects: Use as a Clinical Test Of Ventilatory Function. Brit. J Dist. Chest: 88: 644-650.
• Leith D & Bradley M. (1976). Ventilatory Muscle Strength and Endurance Training. J Appl. Physiol. 41(4): 508-516.
• Living In Rural and Urban Areas in Northern Nigeria J Trop. Paed. 50(4): 209-216.
• Luft FC & Weinberger MH (1997). Heterogeneous responses to changes in dietary salt intake and salt sensitivity paradigm. American journal of clinical nutrition ; 65;612s-617s.
• Majid DS, William A, Navar LG (1993).inhibition of nitric oxide synthesis attenuates pressure – induced natriuretic response in anesthesized dogs. Am j physiol 264; F79 –F87.
• Makartasis KP, Handy DE , Johs C, kobilka B, Gavras I and Avras H (1999).Role of alpha- adrenergic receptor in the development of salt induced hypertension .hypertension;33;14-17.
• Mathers CD and loncor D (2006) Projections of global mortality and burden of disease from 2002.plus med volume 3.page 11.
• Medici T.C and W. Vetter (2009). Bronchial asthma and kitchen salt. Schweiz Med. Wochenschr. 12 Life Hugger. Medical Memories Page 12-19.
• Meneton P, jeunemaitre X, wardner DE, HE and Macgregor G (2005).Links between dietary salt lntake ,renal salt handling, blood pressure and cardiovascular .diseases.; physiology revision ;85;679-715.
• Mickleborough, Robert W, Gotshal R, Cordain L (2000).Dietary salt restriction improves pulmonary function in exercise induced asthma. .American College of sport medicine publication.
• Miller G. J and Sergeant, G. R. (1971). An Assessment of Lung Volumes and Gas Transfer in Sickle Cell Anaemia. Thorax, 26: 309-315.
• Miller, G.1, Ashcroft, M. T, Swan A. V, Beadwell H. (1979). Ethnic Variation in Forced Expiratory Volume and Forced Vital Capacity Of African And Indian Adults In Guyana. Am. Rev. Resp. Dis. 102: 979- 981.
• Miyoshi A, Suzuki H, Fujiwora M (1997). Impairments of endothelial function in salt sensitive hypertension in humans. American journal of Hypertension, vol 10 ,page 1083-1090
• Mueller PJ (2007).Exercise training and sympathetic nervous system activity; evidence for physical activity neural plasticity. Clin exp pharmacol physiol :34(4):377-384.
• Murray, A. B. And Cooke, A. A. (1963): Measurement of Peak Expiratory Flow Rate in 220 Normal Children from 4.5-18.5 Years .J Pead. 56: 187-189.
• Nagarathna R, Nagendra HR.(1985).Yoga for bronchial asthma: a controlled study .British medical journal:291;1077.
• Nakayama T, soma M, Takahasi Y, Rehemudula D, kanmatsuse K, and Furuya K (2009);functional deletion mutation of the 5- flanking region of type A human natriuretic peptide and association with essential hypertension and left ventricular hypertrophy in the Japanese. Circulation and respiration ;vol 86;841-845.
• Nathell I, Nathell M, malmberg P (2007).COPD diagnosis related to different guidelines and spirometry techniques. respiratory research vol 8,page 89
• National lung and blood institute (NLBI);what is COPD,2010
• Noncommunicable Diseases Data Portal. Geneva: World Health Organization; 2022 (https://ncdportal.org/).
• O’bryne P (1997).Exercise induced bronchoconstriction; elucidating the role of leukotrienes and prostaglandins. Pharmacotherapy vol 17 31s-38s.
• Obasohan AO, Okoh VA, Onyia KA and isiah AO (1992).Salt taste threshold in normotensive and hypertensive Nigerians; tropical cardiology vol 18;183-187.
• Odunaga, A. C, Jaja S. I. & Ojo, G.O (1989). Some Ventilatory Parameters In Well-Trained Nigerians Athletes.
• Oduntan S. A. (1970). Spirometric Studies of Normal and Pre-Operative Patients in Nigeria. Afr. 1. Med Sci. 1: 79-84.
• Onadeko B. 0, Iyun A. A, Sofowora E. 0, And Adamu S. O. (1984): Peak Expiratory Flow Rate in Normal Nigerian Children: Afri. 1. Med. Medical Sci. 13: 28-32.
• Onadeko, B. 0, Falase A. O. & Ayeni O. (1976). Pulmonary Function Studies In Nigerian Sportsmen, Afr. J Med. Med. Sci. 5: 291-295 .
• Oparil S, Meng SC, Chen YF, Jin HK and Wyss JM (1988). Genetic basis of sodium chloride sensitive hypertension. journal of cardiovascular pharmacology;12;s56-s69.
• Oritz PA& Garvin JL (2002). Role of NO in the regulation of nephron transport. Am .j renal physiol 282:F777-784.
• Osim E. E & Esin R. A. (1996). Lung Function Studies in Some Nigerian Bank Worker. Central Afr. 1. Med. 42(2): 43-45.
• Osim E. E, Urorn S. E. & Antai A . B. (2004): Symptoms And Lung Function Values In Nigerian Men and Women Exposes To Dust Generated From Crushing Of Giant Rocks in Calabar, Nig. 1. Physiol. Sci. 19(1-2): 41-47.
• Parakash S, Meshiam S, ramilekkar U. (2007). Athletes, yogi’s and individuals with sedentary lifestyles, do their lung function differs ? indian j. physiol pharmacol ;51(1);76-80.
• Paterick TF& fletcher G.(2001). Endothelial function and cardiovascular prevention; role of blood lipids, exercise and other risk factors. Cardiol ;vol 9 (5): 282-286.
• Patrick M & Femi-Pearse D. (1976). Reference Values of FEVl and FVC in Nigerian Men and Women: A Graphical Summary. Nigeria Med. J .6(4): 380-385.
• Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz D, Sheps SG, and Rocella EJ (2005). Recommendations for blood pressure measurement in humans and experimental animals .Part1;blood pressure measurement in humans. A statement for proffessionals from the subcommittee of professional and public education of the American heart association council on high blood pressure research; Hypertension;45;142-161.
• Pitts RF, Ayer JL, shies W.(1949). The renal regulation of acid –base balance in man. J. Clin invest 28:35-44.
• Powars D, Weidman 1. A, Tamara O. M, Niland V. C. And Johnson C. (1988). Sickle Cell Chronic Lung Disease. Prior Morbidity and the Risk of Pulmonary Failure. Medicine, 67: 66-76.
• Raphael 1. C, Elkharat D, Jars-Guincestr M. C, Cahstang C, Cahlrles V, Veekan1. B. And Gahdos, P. (1989).Rail Of Nomobaric and Hyperbaric Oxygen for Acute Carbon Monoxide Intoxification. Lancet. 414-419.
• Rasmussen MS, Simonsen JA, Sandgaard NCF, Hoilund-Carlsen PF and BIe .P (2003).Mechanisms of acute naturesis in normal humans on low sodium diet. Journal of physiology ;vol 546;591-603.
• References on food salt and health issue’s; salt institute. 2009
• Renner J. K, Oduwole A. O. And Jaja S. I. (1999). Effect of Stance on Peak Expiratory Flow Rate: Nig. J Clin. Pract. 2(2): 56-58.
• Reuter H, Blaustein MP and Haeusler.G (1973). NA-CA Exchange and tension development in arterial smooth muscles..
• Romero JC, Lahera V, Ruilope L. (1995). Role of nitric oxide (NO) in the intra-renal regulation of nephron function and it relevance to hypertension. Hypertension: pathophysiology, diagnosis and management. Newyork, NY: Raven press:1385-1404.
• Rosenthal, M., Brain, S. H. Cramer, D., Helms-P, Denison, D, Bush, A. and Warner, 1. O. (1993): Lung Function in White Children Aged 4-19 Years. Thorax: 48(8): 791-802.
• Roskill Information Services.Roskill.com, 2011.
• Rossant R, Konrad JR and Lopez F(1993).Inhaled nitric oxide for ARDS; New eng journ of med;56;399-404.
• Sachdeva A & weder AB (2006).Nocturnal sodium excretion, blood pressure dipping and sodium sensitivity. Hypertension;48;527-533.
• Sacks FM, Sverkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obsarzanek E, Conlin PR, Miller ER, Simmons-Morton DG, karanja N , Lin PH and DASH sodium collaborative research group (2001).Effect of blood pressure on reduced dietary sodium and dietary approach to stop hypertension (DASH) DIET. England journal of medicine.344;3-10.
• Safety Data For sodium Chloride: the Physical and theoretical chemistry laboratory of Oxford University, 2005.
• Salt Institute “Physical Properties”. 2010.
• Salt Raises “Stomach Cancer risk” BBC News Online, 2004.
• Sanders PW (2008). Salt sensitivity; it is not always in the genes. Hypertension 51; 823-824.
• Schmidt and Nielsen (1997). Adaptation and Environment; Animal Physiology. .
• Scientific Advisory Committee on nutrition (SACN) (2003). Salt and Health; Page 3.
• Scientific Advisory Committee on Nutrition (SACN) Salt and Health Page 18.
• Sessa WC, Pritchard K, Seyedi N (1994). Chronic exercise in dogs increases coronary vascular NO production and endothelial NOS gene expression. CIin res 74;349-353.
• Shahidi et al (2005). Asian functional foods: Boca Raton: Page 575,
• Shimamoto K, Hirata A, Fukuoka M, Higashiura K, Miyazaki Y, Shiki M, Masuda A, Limura O (1994). insulin sensitivity and the effect of insulin on renal sodium handling and pressor system in essential hypertensive patients.Hypertension;23:129-133.
• Shultz PJ & tolin JP.(1993).Adaptation to increased dietary salt intake in rat. Role of endogenous nitric oxide. J Clin invest: 642-650.
• Sofola OA (2004). Salt, blood pressure and cardiovascular changes in humans and experimental studies. A review Nigerian medical practice;46;22-26.
• Sonne L. 1. & Davies J. A. (1982): Increased Exercise Performance in Patients with Severe COPD following Inspiratory Resistive Training. Chest, 89: 436.
• Soucy KG, RYoo S, Benjo A, Lim HK, Gupta G and Sohi JS (2006) Impaired shear stress –induced nitric oxide production through decreased NOS phosphorylation contributes to age related vascular stiffness. journal of applied physiology 101;1751-1756.
• Spector .S (1993).Updates on exercise induced asthma .annals of allergy, vol 71,page 571-577
• Spiegel, M. R. (1972). Theory and Problems of Statistics (S. I. Metric Edition). McGraw-Hill Company (Lond.) Ltd, 3rd Edition. Pp. 243.
• Stamler J, Rose G, Elliot P, Marmot M, Kesteloot H and stamler R(1991).findings of the international co-operative INTERSALT study. Hypertension 17;1-9-1-15.
• Stein CM, lang CC, Singh HB and wood AJ (2000).increased vascular vasoconstriction and decreased vasodilation in blacks .Additives mechanisms leading to enhanced vascular reactivity. Hypertension; 36; 945-951.
• Strazulo P, Dellal T, Kondala NB (2006). Salt intake, stroke and cardiovascular disease Meta- analysis of prospective studies; British Medical Journal Vol 339 Page b4 567.
• Stuart D. G. And Collings W. D. (1959). Comparison: Vital Capacity Of Athletes And Non-Athletes, J Appl. Physiol, 14: 507.
• Summy-long JY, Phillips TM, Pruss A (2006). Response of interleukin 1beta in the magnocellular system to salt loading. Journal of neuro endocrinol vol 18, Page 926-937.
• Summy-long JY,Hu S,Pruss A,Chen X, Philps TM.(2006).Response of interleukin -1b in the magnocellular system to salt loading. Neuroendocrinol 18:926-937.
• Swann AC (1985). NA-K ATPase regulation and Sodium intake effect on circulating inhibitors and sensitivity to nor- adrenaline. American. journal of clinical science .vol 69 page 441-447.
• Tinker, C. M. (1961): Peak Expiratory Flow Measured by the Wright's Peak Flow Meter. Distribution Of Values In Man Aged 30-59 Who Denied Respiratory Symptoms. Brit. Med. J 1. 1365-1366.
• Titze J, Krause H, Hccht H, Dictsch P, Rittweger J, Lang R, Kirsch KA and Hilgers KF (2002).Reduced Osmotically inactive NA storage capacity and hypertension in dahl model. American journal of physiology ,vol 285;F134-F141
• Turk E, Schulz. F, Koops E (2005). “Fatal Hyernatremia after using salt as an emetic report of three autopsy cases” Legal Medicine 7 (Vol 1) Page 47 – 50,
• Tzemos N, Lim PO, Struthers AD and Macdonald TM (2008).Adverse cardiovascular effect of acute salt loading in young normotensive individuals. Hypertension, vol 51,Pg 1525-1530.
• Uematsu M, Ohara Y, Navas J P, Nishida K (1995). Regulation of endothelial cell nitric oxide synthase MRNA expression by shock stress. American journal Physiology Vil. 265, Page C 1371 – C1378.
• Ulasi IL, Ijoma CK and Onodugo OD (2010). A community based study of hypertension and cardio metabolic syndrome in a semi-urban and rural communities in Nigeria; BMC health serv res 10;71
• Uzu T, Ishikawa k, Fuji T, Nakamura S, Inenaga T and Kimura G (1997).Sodium restriction shift circadian rhythm of blood pressure from non- dipper to dipper in essential hypertension. Circulation 96;1859-1862
• VanderJagt D. J, Kassam H, Voart V. 1, Agaba P. A, Harkin M, And Glew R. H. (2004): Comparison Of Pulmonary Function Between Children
• Volmer WM ,Sacks FM, Ards J, Appel LJ, bray GA, Simmons-morton DG, Conlin PR, Svetkey LP, Erlinger TP, Moore TJ, Karanja N (2001). For the DASH-sodium trial collaborative research group .effects of diet and sodium inta8ke on blood pressure; subgroup analysis of the DASH-sodium trial. Ann intern medicine 135;1019-1028
• Wang H, Carretero OA, Garvin JL.(2003). Inhibition of apical Na+/H+ exchanger on the macula densa cells auguments tubuloglomerular feedback .hypertension 41.
• Weinberger MH, Miller JZ, Grim CE and Fineberg NS (1986).Definition and characteristics of sodium sensitivity and blood pressure resistance. Hypertension 8;II-127.
• Weinberger MH (1996).salt sensitivity of blood pressure in humans .Hypertension 27;481-490
• West J. B. (1979). Respiratory Physiology - The Essentials. Williams and Wilkins, Baltimore. Pp 206-221.
• William F Ganong; (2006). Review of medical physiology. Twenty- third edition.
• Williams and Wilkins (2007). lippincott’s illustrated review biochemistry 4th edition Page 24-35,
• Wilson TW and Grim CE (1991).Bio-history of slavery and blood pressure difference in blacks today.Hypertension,17;1-122-1-128mor.
• Winberger MH and Fineberg NS (1991). Sodium and volume sensitivity of blood pressure. Age and pressure changes over time. Hypertension 18;67-71
• Winberger MH, Feinberg NS, Fineberg SE And Weinberger M (2001).Salt sensitivity, pulse pressure and death in normal and hypertensive humans; Hypertension, vol 2;429-432.
• Wright, J. L., Iron, V., Wigs, B. And Churg, A. (1988). Cigarette Smoking Potentiates Asbestos-Induced Air Flow Abnormalities. Exp Lung. Res. 14: 537-542.
• Wright, S., (1982). Samson Wright's Applied Physiology 13th Ed. (Oxford Med. Publ), Keale, C.A. Neil E., Joels, N., 612.
• Yamori Y, Liu L, Ikeda K, Mizushima S, Nara Y, and Simpson FO (2001).Different association of blood pressure with 24hours urinary sodium excretion among pre and post- menopausal women. WHO cardiovascular diseases and alimentary comparison (WHO CARDIAC) STUDY. Journal of Hypertension vol 19;535-53
• Yamori Y, Nara Y, Mizushima S, Mano M, Sawamura M, KIhara M and Horic R(1990).International cooperative study on the relationship between dietary factors and blood pressure;a report from the cardiovascular diseases and alimentary comparison (CARDIAC) study. Journal cardiovascular pharmacology vol 16;s 43-s47.
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