Changes in Serum Erythropoietin and Hematological Profile of HAART-Experienced HIV Patients Living with Type 2 Diabetes Mellitus in South-South Nigeria
DOI:
https://doi.org/10.54548/Resum
Human immunodeficiency virus (HIV) infection, HIV medications and type 2 diabetes mellitus adversely affects kidney function including erythropoiesis. However, studies evaluating the coexisting effects of these conditions on serum erythropoietin (EPO) levels and the hematological profile of those affected in southern Nigeria are scarce. In this study, 128 adults between the ages of 18 and 59 years were selected from designated health facilities in southern Nigeria. They were divided into four groups (n=32 persons per group). Fasting/random blood sugar (FBS/RBS) levels, complete blood count (CBC), glycated heamoglobin (HBA1C), serum levels of erythropoietin were determined using standard methods. Results show a significant increase (P < 0.05) in serum EPO and total red blood cell count (TRBC) in the HIV only group compared to other groups. The total white blood cell count (TWBC), platelets count and platelet/lymphocyte rato increased in the diabetic plus HIV group. The FBS/RBS and theHBA1C levels increased in the diabetic and diabetic plus HIV groups compared to others. Increased erythropoiesis, depicted by increased serum EPO and TRBC could be attributable to improved use of HIV medications and improved lifestyle among the HIV positive patients on treatment. Poorly controlled T2DM with resultant increased HBA1C levels in the diabetic and diabetic plus HIV groups was responsible for the increase in TWBC and platelet count, likely due to impaired immune function leading to sepsis in these groups.
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References
1. Zaidi, J., Grapsa, E., Tanser, F., Newell, M and Barnghausen, T. (2013). Drammatic increases in HIV prevalence after scale-up of antiretroviral treatment: a longitudinal population based HIV surveillance study in rural Kwazulu-natal. AIDS, 27(14): 2301-2305.
2. Lin, S. P., Wu, C., Wang, C., Li, T., Ko, N and Shi, Z. (2018). Risk of diabetes mellitus in HIV-infected patients receiving highly active antiretroviral therapy: A nationwide population-based study. Medicine, 97(36): 12268 -12269.
3. Abu-Ashour, W., Twells, L., Valcour, J., Randell, A., Donnan, J., Howse, P., and Gamble, J. (2017). The association between diabetes mellitus and incident infections: a systematic review and meta-analysis of observational studies: BMJ Open Diabetes Research and Care, 5: 336-337.
4. Teeka, J. S., Mutai, J and Kangogo, M. (2024). Factors associated with opportunistic infections among HIV/AIDS patients attending comprehensive care clinic at Mbagathi District Hospital, Nairobi Kenya: a cross-sectional study. Pan-African Medical Journal-one Health, 13(22): 41950-40951.
5. Kaur, S. (2017). Sampe size detrmination for descriptive studies. International Journal for Current Research, 9(03): 48365-48367
6. Umar, D. M and Naidoo, P. (2021). Prevalence and predictors of diabetes mellitus among persons living with HIV: a retrospective cohort study conducted in four public healthcare facilities in KwaZulu-Natal. Bombay Municipal Cooperation Public Health, 21: 288.
7. Warrier, V., Krishan, K., Shdge, R and Kanchan, T. (2023). Height Assessment. In: StatPearls, Treasure Island, Florida.
8. Chaila, M. Z., Viniegra, M., Gagliardino, J. J., Martinez, A., Bielke, M. G., Frusti, M., Monaco L., Salgado, P., Buso, C., Gonzalez, C. D and Commendatore, V. F. (2021). glycated hemoglobin measrement: comparism of thee methods versus high performance liquid chromatography. Journal of Diabetes Science and Technology, 16(3): 724-731.
9. Marsden, J. T. (2006). Erythropoietin measurement and clinical application. The Association for Clinical Biochemistry, 43: 97-104.
10. Schoener, B and Borger, J. (2024). Erythropoietin Stimulating Agents. StatPearls Publishing, Treasure Island, Florida, 997p.
11. Begemann, M., Gross, O and Wincewicz, D. (2021). Addressing the ‘hypoxia paradox’ in severe covid-19: literature review and report of four cases treated with erythropoietin analogues. Molecular Medicine, 27:120-121.
12. Chang, K., Tam, M., and Stevenson, M. (2004). Modulation of the Course and Outcome of Blood-Stage Malaria by Erythropoietin-Induced Reticulocytosis. The Journal of Infectious Diseases, 189(4): 735–743.
13. Fattizo, B., Languille, L and Levati, G (2019). Evidence based use of erythropoietin in patients with autoimmune haemolytic anaemia: a multicenter international study. Abstract NS900. Presented at the 24th European Haematology Assosciation Annual Congress, June 15, Amstardam, The Netherlands.
14. Obeagu, E. I and Obeagu, G. U. (2024). The crucial role of erythropoietin in managing anemia in HIV: a review. Elite Journal of Scientific Research and Review, 2(1): 24-36.
15. Okolo, R. C., Ufelle, S.A., Achukwu, P. U., Onah, C. A and Ugwu, I. B. (2022). Effects of HIV Infection on Cluster of Differentiation 4 And Erythropoietin Values as Predictive Indicators in HIV Infected Patients Receiving Haart at G.H Nsukka in Enugu. Advances in Clinical and Medical Research, 3(3):1-9.
16. Katz, O., Stuible, M., Golishevski, N., Lifshitz, L., Tremblay, M. L., Gassmann, M., Mittelman, M and Neumann D. (2010). Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models. Journal of Endocrinology, 205: 87–95.
17. Adane, T., Asrie, F., Getaneh, Z and Getawa, S. (2021). White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross-sectional study. Journal of Clinical Laboratory Analysis, 35(6): 808-809.
18. Mastrogiacoma, L., Ballagh, R., Venegas-Pino, D. E., Kaur, H., Shi, P and Werstuck, G. H. (2023). The effect of hyperglycemia on early endothelial activation and initiation of atherosclerosis. The American Journal of Patholgy, 193(1): 121-133.
19. Brar, S. K., Perveen, S., Chaudhry, M. R., AlBabtain, S., Amreen, S and Khan, S. (2021). Erythropoietin-Induced Hypertension: A Review of Pathogenesis, Treatment, and Role of Blood Viscosity. Cureus, 13(1): 804-806.
20. Preyanka, P., Somasundram, P and Nobuhle, M. (2020). The spectrum of electrolyte abnormalities in black African people living with human immunodeficiency virus and diabetes mellitus at Edendale Hospital, Pietermaritzburg, South Africa. South African Journal of HIV Medicine, 21(1): 1-8.
21. Luethi, N., Cioccari, L., Crisman, M., Bellomo, R., Eastwood, G. M and Martensson, J. (2016). Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill. Critical Care, 20: 297-298.
22. Ikpe, I. L., Ekpenyong, C. E., Udokang, N. E and Inwang, U. A. (2025). Hydration status and glycemic indices of patients with type 2 diabetes mellitus and HIV comorbidities in South-South Nigeria. International Journal of Research in Interdisciplinary Studies, 3(5): 2584-1017.
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