ABO Blood Group Genotypes and Demographic Traits in Susceptibility to Type 1 Diabetes Mellitus in Lagos, Southwest, Nigeria
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Yahaya, T., Abdullahi, H., Muhammad, Z., Ibrahim, Y., Abdullahi, M., Ribah, S., & Jimoh, M. (2023). ABO Blood Group Genotypes and Demographic Traits in Susceptibility to Type 1 Diabetes Mellitus in Lagos, Southwest, Nigeria. Nigerian Journal of Physiological Sciences, 37(2), 199–205. https://doi.org/10.54548/njps.v37i2.6


Studies have shown that ABO blood groups and demographic traits influence susceptibility to type 1 diabetes mellitus (T1DM) and can be used in combination with insulin therapy to reduce the disease’s burden. However, geographical variations exist in the influence of demographic traits and ABO blood groups on susceptibility to diseases and thus require establishing it in every locality. This study determined the influence of demographic traits and ABO blood groups on the prevalence of T1DM in Lagos, Nigeria. A structured checklist was used to collect data from the health records of non-obese 150 type 1 diabetic patients at Ayobo Primary Health Center, Lagos. The results revealed that males, with 88 participants (52.7%), constituted the majority, while females had 62 (41.3%). The age group 40 years and older had the highest proportion of participants with 37 (24.7%), followed by 31-40 years with 32 (21.30%), 21-30 years with 30 (20%), 11-20 years with 27 (18%), and 1-10 years with 24 (16%). Christianity had the highest with 74 participants (49.3%), followed by Islam with 71 participants (47.3%), and traditional religion with 5 participants (3.3%). Eight (5.3%) of the participants were primary school graduates; 34 (22.7%) were secondary school graduates; and 108 (72%) were tertiary school graduates. The Yoruba ethnic group, with 77 participants (51.3%), was the most prevalent, followed by Igbo with 50 (33.3%), and Hausa with 3 (2.0%). ABO blood group A and B (positive and negative) individuals were the most diabetic and expressed the most severe cases, while group O positive and AB negative individuals were the least diabetic. T1DM prevention should be a priority for blood group A and B residents.

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Abegaz, S.B. (2021). Human ABO Blood Groups and Their Associations with Different Diseases. BioMed Research International, Article ID 6629060. https://doi.org/10.1155/2021/6629060.

Adewumi, O.O., Oladele, E.O., Jegede, O.S. (2022). Risk Factors and Prevalence of Diabetes Mellitus among Residents of Lagos, Nigeria. African Journal of Health, Safety and Environment, 3 (1): 35-43. DOI: 10.52417/ajhse.v3i1.198.

Akinnuga, A.M., Bamidele, O., Amosu, A.M., Ugwah, G.U. (2011). Distribution of ABO and Rh Blood Groups among Major Ethnic Groups of Medical Students of Madonna University Teaching Hospital, Elele, Nigeria. Asian Journal of Medical Sciences, 3(3): 106-109. https://maxwellsci.com/print/ajms/v3-106-109.pdf.

Alanazi, M. A. A., Abdullah M., Alkhidhr, S., Mohammed, M.A.S., Al-Hathloul, A. W., Alsharif, E.J., Albahli, S.F.A., Alshagraawi, S.A.S., AlJerani, F.M., Almesned, I.S. (2018). Association of Diabetes Mellitus with ABO Blood Groups & Rh. The Egyptian Journal of Hospital Medicine, 73 (4): 6535-6540. https://dx.doi.org/10.21608/ejhm.2018.15408.

Amadi, C., Ayoade, O.G., Onung, S.I., Essien, S.I., Etuk, A.A., Okafor, C.J. (2020). Pattern, Trend and Predictors of Adult-Onset Type 1 Diabetes in Uyo, Nigeria. Dubai Diabetes and Endocrinology Journal, 26 (3): 119-127. doi: 10.1159/000511242.

Balcha, S.A., Demisse, A.G., Mishra, R., Vartak, T., Cousminer, D.L., Hodge, K.M., Voight, B.F., Lorenz, K., Schwartz, S., Jerram, S.T., Gamper, A., Holmes, A., Wilson, H.F., Williams, A.J.K., Grant, S.F.A., Leslie, R.D., Phillips, D.I.W., Trimble, E.R. (2020). Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia. Diabetologia, 2020 63(10):2158-2168. doi: 10.1007/s00125-020-05229-x.

Bener, A., Yousafzai, M.T. (2014). The distribution of the ABO blood groups among the diabetes mellitus patients in Qatar. Nigeria Journal of Clinical Practices, 17:565-568. DOI: 10.4103/1119-3077.141418.

Cleveland Clinic (2022). Type 1 Diabetes. Available at https://my.clevelandclinic.org/health/diseases/21500-type-1-diabetes (Accessed July 18, 2022).

Cousin, E., Duncan, B.B., Stein, C., Ong, K.L., Vos, T., Abbafati, C. (2022). Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019. The Lancet Diabetes & Endocrinology, 10 (3): 177-192. https://doi.org/10.1016/S2213-8587(21)00349-1.

Damiens, A.P., Ganga –Zandzou, P.S., Ibounde, E.T., Kayemba-Kay's, S., Baye, E., Biloghe, P., Kakou, C., Ntyonga-Pono, P. (2019). Type 1 diabetes mellitus in Gabon: A study of epidemiological aspects. International Journal of Pediatrics and Adolescent Medicine, 6 (3): 87-91. https://doi.org/10.1016/j.ijpam.2019.02.007.

Desai, M.K., Brinton, R.D. (2019). Autoimmune disease in women: endocrine transition and risk across the lifespan. Frontiers in Endocrinology. 2019; 10:265. DOI: 10.3389/fendo.2019.00265

Diaz-Valencia, P. A., Bougnères, P., Valleron, A. J. (2015). Global epidemiology of type 1 diabetes in young adults and adults: a systematic review. BMC Public Health, 15: 255. https://doi.org/10.1186/s12889-015-1591-y.

Distiller, L.A. (2014). Why do some patients with type 1 diabetes live so long? World Journal of Diabetes, 5(3): 282–287. Doi: 10.4239/wjd.v5.i3.282.

Ghafar, M., Khwaja, S., Zahid, M., Hussain, S.I., Karim, A., Akram, A. (2021). Association of blood groups/Rh and diabetes mellitus in Karachi city, Pakistan. Brazilian Journal of Biology, 84: e252952 https://doi.org/10.1590/1519-6984.252952.

Giwa, A.M., Ahmed, R., Omidian, Z., Majety, N., Karakus, K.E., Omer, S.M., Donner, T., Hamad, A.R.A. (2020). Current understandings of the pathogenesis of type 1 diabetes: Genetics to environment. World Journal of Diabetes, 11(1): 13-25. DOI: 10.4239/wjd.v11.i1.13.

Harding, J.L., Wander, P.L., Zhang, X., Li, X., Karuranga, S., Chen, H., Sun, H., Xie, Y., Oram, R.A., Magliano, D.J., Zhou, Z., Jenkins, A.J., Ronald C.W. (2022). The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review from 32 Countries and Regions. Diabetes Care, 45 (4): 994–1006. https://doi.org/10.2337/dc21-1752.

IDF (International Diabetes Federation) (2020). Type 1 diabetes. Available at https://www.idf.org/aboutdiabetes/type-1-diabetes.html (Accessed July 18, 2022).

IDF (International Diabetes Federation) (2021). Diabetes facts & figures. IDF Diabetes Atlas Tenth edition 2021. Available at https://idf.org/aboutdiabetes/what-is-diabetes/facts-figures.html (Accessed July 18, 2022).

Kahanovitz, L., Sluss, P. M., Russell, S. J. (2017). Type 1 Diabetes - A Clinical Perspective. Point of Care, 16(1): 37–40. https://doi.org/10.1097/POC.0000000000000125.

Khanolkar, A.R., Amin, R., Taylor-Robinson, D. (2017). Ethnic differences in early glycemic control in childhood-onset type 1 diabetes. BMJ Open Diabetes Research and Care, 5:e000423. doi: 10.1136/bmjdrc-2017-000423.

Kim, K., Park, S.M. (2018). Association of muscle mass and fat mass with insulin resistance and the prevalence of metabolic syndrome in Korean adults: a cross-sectional study. Scientific Report, 8(1):2703. https://doi.org/10.1038/s41598-018-21168-5.

Kyvik, K.O., Nystrom, L., Gorus, F., Songini, M., Oestman, J., Castell, C., Green, A., Guyrus, E., Ionescu-Tirgoviste, C., McKinney, P.A., Michalkova, D., Ostrauskas, R., Raymond, N.T. (2004). The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children. Diabetologia, 47(3): 377–384. https://doi.org/10.1007/s00125-004-1331-9.

LatitudeLongitude.org (2015). Lagos, Nigeria latitude longitude. Available at https://latitudelongitude.org/ng/lagos/ (Accessed July 21, 2022).

Maahs, D.M., West, N.A., Lawrence, J.M., Mayer-Davis, E.J. (2010). Epidemiology of type 1 diabetes. Endocrinology and Metabolism Clinics of North America, 39(3):481–97. https://doi.org/10.1016/j.ecl.2010.05.011.

Ogundele, S.O., Dada, A.O., Mosuro, O.R. (2016). Clinical profile, knowledge, and beliefs about diabetes among patients attending a Tertiary Health Centre in Lagos: A cross-sectional survey. Nigeria Journal of Clinical Practice, 19:508-12. https://doi.org/10.4103/1119-3077.183303.

Okon, U.A., Antai, A.B., Osim, E.E., Ita, S.O. (2008). The relative incidence of diabetes mellitus in ABO/Rhesus blood groups in South-Eastern Nigeria. Nigerian Journal of Physiological Sciences, 23 (1-2): 1-3. DOI: 10.4314/njps.v23i1-2.54897.

Oladele, E.O., Yahaya, T.O., Adewunmi, O.O., David, B., Oladipo, A.J. (2020) Distribution of ABO/rhesus blood groups among hepatitis B virus (HBV) positive patients in Lagos, South-Western, Nigeria. FUDMA Journal of Science, 4(3):196–200. https://doi.org/10.33003/fjs-2020-0403-127.

Olssen, L., Ahlbom, A., Grill, V., Midthjell, K., Calsson, S. (2011). High levels of education are associated with an increased risk of latent autoimmune diabetes in adults. Diabetes Care, 34 (1):102–107. https://doi.org/10.2337%2Fdc10-1061.

Oner, C., Dogan, B., Telatar, B., Celik-Yagan, C.F., Oguz, A. (2016). Frequency of ABO/Rhesus Blood Groups in Patients with Diabetes Mellitus. Journal of the College of Physicians and Surgeons--Pakistan, 26(1):74-5. https://pubmed.ncbi.nlm.nih.gov/26787039/.

Ordooei, M., Namiranian, N., Jam –Ashkezari, S., Jalali, H., Golzar, A. (2022). Is type 1 diabetes mellitus associated with ABO & Rh blood groups? A cross -sectional study. Iranian Journal of Pediatric Hematology and Oncology, 1 (1): 49 -54. 10.18502/ijpho.v12i1.8362.

Ostman, J., Lönnberg, G., Arnqvist, H. J., Blohmé, G., Bolinder, J., Ekbom Schnell, A., Eriksson, J. W., Gudbjörnsdottir, S., Sundkvist, G., Nyström, L. (2008). Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002. Journal of Internal Medicine, 263(4):386–394. https://doi.org/10.1111/j.1365-2796.2007.01896.x.

Padoa, C. (2011). The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa. Journal of Endocrinology, Metabolism and Diabetes of South Africa, 16(3):130–136. https://doi.org/10.1080/22201009.2011.10872264.

Patterson, C.C., Karuranga, S., Salpea, P., Saeedi, P., Dahlquist, G., Soltesz, G., Ogle, G.D. (2019). Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice, 157: 107842. https://doi.org/10.1016/j.diabres.2019.107842.

Rachna, P., Satish, R.K. (2022). Type 1 diabetes mellitus in pediatric age group. Journal of Family Medicine and Primary Care, 11(1): 27-31 doi: 10.4103/jfmpc.jfmpc_975_21.

Redondo, M.J., Geyer, S., Steck, A.K., Sharp, S., Wentworth, J. M., Weedon, M.N., Antinozzi, P., Sosenko, J., Atkinson, M., Pugliese, A., Oram, R.A. (2018). A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk. Diabetes care, 41(9):1887–1894. https://doi.org/10.2337/dc18-0087.

Salti, I., Bénard, E., Detournay, B., Bianchi-Biscay, M., Le Brigand, C., Voinet, C., Jabbar, A.A. (2004). Population-Based Study of Diabetes and its Characteristics during the Fasting Month of Ramadan in 13 Countries: Results of the Epidemiology of Diabetes and Ramadan 1422/2001 (EPIDIAR) study. Diabetes Care, 27 (10): 2306–2311. https://doi.org/10.2337/diacare.27.10.2306.

Seiglie, J.A., Marcus, M-E., Ebert, C., Prodromidis, N., Geldsetzer, P., Theilmann, M. (2020). Diabetes Prevalence and Its Relationship with Education, Wealth, and BMI in 29 Low- and Middle-Income Countries. Diabetes Care, 43 (4): 767–775. https://doi.org/10.2337/dc19-1782.

Shittu, R.O., Kasali, F.O., Biliaminu, S.A., Odeigah, L.O., Sule, A.G., Musah, Y. (2017). Prevalence of Diabetes and Pre-Diabetes in Oke- Ogun Region of Oyo State, Nigeria. Journal of Medical Research and Health Education, 1:1.

Sussman, M., Benner, J., Haller, M.J., Rewers, M., Griffiths, R. (2020). Estimated Lifetime Economic Burden of Type 1 Diabetes. Diabetes Technology & Therapeutics, 22 (2): 121-130.http://doi.org/10.1089/dia.2019.0398.

Tosur, M., Geyer, S.M., Rodriguez, H., Libman, I., Baidal, D.A., Redondo, M.J. (2018). Type 1 Diabetes TrialNet Study Group. Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk. Diabetologia, 61(9):2043-2053. doi: 10.1007/s00125-018-4660-9.

Umar, U.I. (2016). Pattern of presentation of Type 1 diabetic patients in Kano, Nigeria. Nigerian Journal of Basic and Clinical Science, 13:85-88. DOI: 10.4103/0331-8540.187361.

VYMaps.com (2022). Ayobo Primary Health Care Centre. Available at https://vymaps.com/NG/Ayobo-Primary-Health-Care-Centre-364755/ (Accessed July 21, 2022).

Wändell, P.E., Carlsson, A.C. (2013). Time trends and gender differences in incidence and prevalence of type 1 diabetes in Sweden. Current Diabetes Reviews, 9(4): 342–349. https://doi.org/10.2174/15733998113099990064.

Yahaya, T., Obaroh, I.O., Oladele, E.O. (2017a). The Roles of Environmental Pollutants in the Pathogenesis and Prevalence of Diabetes: A Review. Journal of Applied Science and Environmental Management, 21 (1): 5-8. http://dx.doi.org/10.4314/jasem.v21i1.1.

Yahaya, T., Obaroh, I.O., Oladele, E.O. (2017b). The Roles of Microorganisms in the Pathogenesis and Prevalence of Diabetes: A Review. African Journal of Diabetes Medicine, 25 (2): 13 15.

Yahaya, T.O., Oladele, E.O., Mshelia, M.B. (2021a) Influence of ABO blood groups and demographic characteristics on the prevalence of type 2 diabetes in Lagos, southwest Nigeria. Bulletin of National Research Center, 45:144. https://doi.org/10.1186/s42269-021-00603-0.

Yahaya, T., Oladele, E., Nnochiri, K., Abdullahi, H., Nathaniel, J. (2021b). Genetic Susceptibility to Coronavirus Disease 19 (COVID-19): A Review. The University of Toledo Journal of Medical Sciences, 9(1): 6-11. Retrieved from https://openjournals.utoledo.edu/index.php/translation/article/view/408.

Yahaya, T., Salisu, T. (2020). Genes predisposing to type 1 diabetes mellitus and pathophysiology: a narrative review. Medical Journal of Indonesia, 29:100–109. https://doi.org/10.13181/mji.rev.203732.

Yahaya, T., Shemishere, U. (2020). Association between Bioactive Molecules in Breast Milk and Type 1 Diabetes Mellitus. Sultan Qaboos University Medical Journal, 20(1):e5-e12. doi: 10.18295/squmj.2020.20.01.002.

Yahaya, T., Ufuoma, B.S. (2019). Role of epigenetics in aetiology and therapies for Type 1 Diabetes Mellitus: A narrative review. Journal of Health and Social Sciences, 4 (2):199-212. https://doi.org/10.19204/2019/rlfp12.

Yamane, T. (1973). Statistics, an Introductory Analysis, 2nd Ed., Harper and Row, New York.

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