Neurobehavioural and Histological Study of the Effects of Low-Dose and High-Dose Vanadium in Brain, Liver and Kidney of Mice


  • Taidinda Gilbert Department of Veterinary Anatomy, University of Ibadan
  • Francis Olaolorun Department of Veterinary Anatomy, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria
  • Amany Ladagu Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria
  • Funmilayo Olopade Department of Anatomy, University of Ibadan, Ibadan, Nigeria
  • Olumayowa Igado Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria
  • James Olopade Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria



Vanadium is a ubiquitous transition metal that has been generating contrasting research interest. Therapeutically, vanadium possess antidiabetic, antitumor, antiparasitic and even neuroprotective activities. On the flip side, vanadium has been reported to cause multisystemic toxicities with a strong predilection for the nervous system. Despite several reports on potential benefits of low-dose vanadium (LDV) and toxic effects of high-dose vanadium (HDV), there are no comparative studies done thus far. This study therefore explored the comparative effects of LDV and HDV exposure in mice during postnatal development. A total of nine (9) nursing mice were used in this study; with three nursing mice and their pups (n = 12 pups per group) randomly assigned to each of the three test groups. The nursing dam were given intraperitoneal (i.p) injection of vanadium at 0.15mg/kg and 3mg/kg for LDV and HDV respectively, and subseqently to the pups from postnatal day (PND) 15 till sacrifice on PND 90. We discovered that neurodevelopmental motor function test of mice-pups exposed to LDV here showed improved motor development, muscular strength and memory capacities whereas HDV led to motor function impairment, reduced muscular strength and memory capacities.  LDV-exposed mice showed mild histological lesions in cerebral cortex whereas high-dose showed distinct histological lesions in different parts of the brain ranging from cerebellar Purkinje neuronal pathology (central chromatolysis), pyramidal neuronal loss in CA1 region, architectural distortion as well as fewer neurons in olfactory bulb. We saw mild lesions with LDV in both liver and kidney, however, with HDV exposure, there was diffuse hepatocellular vacuolar degeneration and congestion of blood vessels in liver, shrinkage of renal glomerulus and degenerated epithelial cells of kidney. Conclusively, beneficial effect of vanadium is proven as it facilitated body weight gain which translate in organ weight at low-dose, while high-dose caused decreased neurobehaviour and histological lesions.

Author Biographies

  • Taidinda Gilbert, Department of Veterinary Anatomy, University of Ibadan

    Dr Gilbert is a veterinary doctor, presently pursuing his PhD degree in the department of Veterinary Anatomy, University of Ibadan.

  • Francis Olaolorun, Department of Veterinary Anatomy, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria

    Dr Olaolorun is a veterinary doctor and lecturer at the department of eterinary Anatomy, FederalUniversity of Agriculture, Abeokuta, Nigeria. He is currently pursuing his PhD degree at the department of Veterinary Anatomy, University of Ibadan. Nigeria.

  • Amany Ladagu, Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria

    Miss Ladagu is a PhD student in the department of Veterinary anatomy, University of Ibadan, Nigeria.

  • Funmilayo Olopade, Department of Anatomy, University of Ibadan, Ibadan, Nigeria

    Dr Olopade is a medical doctor and senior lecturer in the department of Anatomy, College of Medicine, University of Ibadan.

  • Olumayowa Igado, Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria

    Dr Igado is a veterinary doctor and senior lecturer at the department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.

  • James Olopade, Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria

    Prof. Olopade is a veterinary doctor and professor at the Department of Vetrinary Anatomy, University of Ibadan, Nigeria.


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How to Cite

Neurobehavioural and Histological Study of the Effects of Low-Dose and High-Dose Vanadium in Brain, Liver and Kidney of Mice. (2023). Nigerian Journal of Physiological Sciences, 38(1), 47-56.