Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice
DOI:
https://doi.org/10.54548/njps.v38i2.11Keywords:
Cinnamon,, Depression, Cognitive impairment,, Immobility time,, Behavioural despairAbstract
Depression is a mental disorder characterized by depressive episodes, such as low mood, low self-esteem, feeling of guilt, and poor concentration. Depression has a high comorbidity with cognitive impairments. Studies have shown that cinnamon has anti-inflammatory antiviral, antihypertensive, antioxidant and anti-diabetic potentials. Therefore, the aim of the research was to assess the antidepressant effect of cinnamon on open-space forced swim-induced depression in mice. Twenty-five (25) Swiss albino mice were grouped into five groups (n=5). Group I: control (negative control) exposed to open-space forced swim test (OSFST) without any treatment, Groups II, III and IV received graded doses of Cinnamon 12.5, 25, and 50 mg/kg, group 5 (positive control) received fluoxetine 20 mg/kg orally. The animals were subjected to OSFST, Open Field Test (Line Crossing) and Novel Object Recognition Test (NORT). Administration of cinnamon showed decreased immobility time (behavioural despair) in OSFST compared to control and fluoxetine groups (p < 0.05). However, no statistically significant effect was observed in line crossing (locomotor activity) and the discrimination ratio of NORT (non-spatial short-term memory) between cinnamon administered groups and the control group. In conclusion, cinnamon has shown antidepressant-like effect in open-space forced swim-induced depression in mice.
Keywords: Cinnamon, Depression, Cognitive impairment, Immobility time, Behavioural despair
References
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Yusha’u, Y., Muhammed, U. A., Nze, M., Egwuma, J. M., Igomu, O. J., and Abdulkadir, M. (2017). Modulatory Role of Rutin Supplement on Open Space Forced Swim Test Murine Model of Depression. 32(December), 201–205.
Yusha’u, Y, Mustapha, S., Umar, A. H., Imam, M. I., & Umar, B. (2021). Alpha-lipoic acid attenuates depressive symptoms in mice exposed to chronic unpredictable mild stress . 9(July), 58–68.
Yusha’u, Yusuf, Adam, U. M., Wahab, A. A., Ibrahim, M., & Saleh, A. (2021). OPEN ACCESS | RESEARCH NOTES Alpha-lipoic acid enhances short-term spatial memory of mice in open-space forced swim-induced depression mouse model.
Zhang, R., Xue, G., Wang, S., Zhang, L., Shi, C., & Xie, X. (2012). Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A  PP / PS1 Alzheimer ’ s Disease Mouse Model. 31, 801–812. https://doi.org/10.3233/JAD-2012-120151
Abdeen, A., Abdelkader, A., Abdo, M., Wareth, G., Aboubakr, M., Aleya, L., and Abdel-Daim, M. (2018). Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue. Environmental Science and Pollution Research, 26(1): 240-249. https://doi.org/10.1007/s11356-018-3553-2
Bagewadi, H. G., Ak, A. K., & Shivaramegowda, R. M. (2015). An Experimental Study to Evaluate the Effect of Memantine in Animal Models of Anxiety in Swiss Albino Mice. 2–6. https://doi.org/10.7860/JCDR/2015/13233.6287
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016). Cognitive remission : a novel objective for the treatment of major depression ? BMC Medicine, 1–18. https://doi.org/10.1186/s12916-016-0560-3
Brent, D. A. (2016). A n t i d e p re s s a n t s a n d Suicidality. Psychiatric Clinics of NA, 39(3), 503–512. https://doi.org/10.1016/j.psc.2016.04.002
Calheiros, M., Silva, C., Nádia, C., Sousa, S. De, Xavier, P., Gomes, L., Valente, G., Oliveira, D., Yvelize, F., Araújo, R., Coelho, N., Calheiros, J., Silva, G., Kalyne, L., Moreira, A., Macêdo, D., Maria, S., & Vasconcelos, M. (2016). Progress in Neuro-Psychopharmacology & Biological Psychiatry Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice. Progress in Neuropsychopharmacology & Biological Psychiatry, 64, 142–148. https://doi.org/10.1016/j.pnpbp.2015.08.002
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010). A Meta-Analysis of Cytokines in Major Depression. BPS, 67(5), 446–457. https://doi.org/10.1016/j.biopsych.2009.09.033
Favrod-coune, T., & Broers, B. (2010). The Health Effect of Psychostimulants: A Literature Review. 2333–2361. https://doi.org/10.3390/ph3072333
Hu, B., Doods, H., Treede, R., & Ceci, A. (2016). Neuroscience Letters Duloxetine and 8-OH-DPAT , but not fluoxetine , reduce depression-like behaviour in an animal model of chronic neuropathic pain. Neuroscience Letters, 619, 162–167. https://doi.org/10.1016/j.neulet.2016.03.019
Jana, A., Modi, K. K., Roy, A., Anderson, J. A., & Breemen, R. B. Van. (2013). Up-Regulation of Neurotrophic Factors by Cinnamon and its Metabolite Sodium Benzoate : Therapeutic Implications for Neurodegenerative Disorders. 739–755. https://doi.org/10.1007/s11481-013-9447-7
Kalin, N. H. (2020). The Critical Relationship Between Anxiety and Depression. May, 365–367. https://doi.org/10.1176/appi.ajp.2020.20030305
Kawatra, P., & Rajagopalan, R. (2015). Cinnamon : Mystic powers of a minute ingredient. 7, 1–6. https://doi.org/10.4103/0974-8490.157990
Kelestemur, T., Yulug, B., Burak, A., & Caglar, M. (2016). Neuroscience Letters Targeting different pathophysiological events after traumatic brain injury in mice : Role of melatonin and memantine. Neuroscience Letters, 612, 92–97. https://doi.org/10.1016/j.neulet.2015.11.043
Khawam, E. A. (2006). Side effects of antidepressants : An overview. 73(4).
Martinowich, K., & Lu, B. (2008). Interaction between BDNF and Serotonin : Role in Mood Disorders. 73–83. https://doi.org/10.1038/sj.npp.1301571
Mustapha, S., Oshafu, M. Y., Adam, U. M., Yusha'u, Y., & Daku, A. B. (2021). Influence of Antidepressant Medication on Short Term Memory in Chronic Mild Stress Mouse Model of Depression. 12(1), 22–28.
Parisa, N., Tamzil, N. S., Arroyantri, B., & Maritska, Z. (2020). Antidepresant effects of Cinnamon ( Cinnamomum burmannii ) extract in depressed induced rats using 3-minutes Tail Suspension method Antidepresant effects of Cinnamon ( Cinnamomum burmannii ) extract in depressed induced rats using 3-minutes Tail Suspension method. August 2019. https://doi.org/10.32539/bsm.v3i3.91
Partan, R. U. M. I., Hidayat, R., Saleh, M. G. S. I., Parisa, N., & Tanzil, N. I. A. S. (2018). EFFECT OF SUPPLEMENTATION KAYU MANIS ( CINNAMOMUM BURMANNII ) EXTRACT IN NEURONAL CELL DEATH PROTECTION IN WISTAR RATS LIR-PSYCHOTIC ON HALOPERIDOL THERAPY. 11(2).
Santos, H. O., & Guilherme, A. R. (2018). Clinical Nutrition ESPEN To what extent does cinnamon administration improve the glycemic and lipid pro fi les ? Clinical Nutrition ESPEN, 1–9. https://doi.org/10.1016/j.clnesp.2018.07.011
Simplice, F. H., Emery, T. D., Abaissou, N., & Hervé, H. (2014). Enhancing Spatial Memory : Anxiolytic and Antidepressant Effects of Tapinanthus dodoneifolius ( DC ) Danser in Mice. 2014.
Thur, K. E., Nelson, A. J. D., & Cassaday, H. J. (2014). Ro 04-6790-induced cognitive enhancement : No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats Pharmacology , Biochemistry and Behavior Ro 04-6790-induced cognitive enhancement : No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats. November. https://doi.org/10.1016/j.pbb.2014.10.006
Wood, S., Sage, J. R., Shuman, T., & Anagnostaras, S. G. (2014). Psychostimulants and Cognition : A Continuum of Behavioral and Cognitive Activation. 15261(January), 193–221.
Yusha’u, Y., Muhammed, U. A., Nze, M., Egwuma, J. M., Igomu, O. J., and Abdulkadir, M. (2017). Modulatory Role of Rutin Supplement on Open Space Forced Swim Test Murine Model of Depression. 32(December), 201–205.
Yusha’u, Y, Mustapha, S., Umar, A. H., Imam, M. I., & Umar, B. (2021). Alpha-lipoic acid attenuates depressive symptoms in mice exposed to chronic unpredictable mild stress . 9(July), 58–68.
Yusha’u, Yusuf, Adam, U. M., Wahab, A. A., Ibrahim, M., & Saleh, A. (2021). OPEN ACCESS | RESEARCH NOTES Alpha-lipoic acid enhances short-term spatial memory of mice in open-space forced swim-induced depression mouse model.
Zhang, R., Xue, G., Wang, S., Zhang, L., Shi, C., & Xie, X. (2012). Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A  PP / PS1 Alzheimer ’ s Disease Mouse Model. 31, 801–812. https://doi.org/10.3233/JAD-2012-120151
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