Methanolic extract of Citrullus Lanatus seeds abates testicular degeneration and dose-dependently modulates testicular function in hyperlipidemic male Wistar rats.

Authors

  • Mr. Ofovwe Ekakitie Department of Physiology, Alex Ekwueme Federal University, Ndufu Alike, ikwo, Ebonyi State.
  • F.E Okoro
  • E.J. Nwite
  • C Chukwunweike
  • C.C. Fredrick
  • C.U. Emelike

Abstract

Hyperlipidemia is emerging as an important cause of adverse health outcomes including cardiovascular complications, obesity, metabolic disorders, and infertility. A total of twenty-five (25) male albino Wistar rats were divided into five groups (n=5): Normal control, Hyperlipidemic control group which was administered (intra-peritoneal) with 0.2ml/10g body weight of egg yolk and then terminated after twenty-four (24) hours, Hyperlipidemic non-treated group which were administered with 0.2ml/10g body weight of egg yolk and were left throughout the treatment period. Hyperlipidemic low-dose treated group (administered 0.2ml/10g body weight of egg yolk, 800mg/kg body weight of methanolic extract of Citrullus lanatus seed-MECLS), and Hyperlipidemic high-dose treated group (administered 0.2ml/10g body weight of egg yolk, and 1600mg/kg body weight of MECLS).  No significant change was observed in testosterone levels and sperm count across all groups. However, a statistically significant increase (P<0.05) in luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels was observed in Hyperlipidemic non-treated and Hyperlipidemic low-dose treated group when compared to Normal Control Group. They also showed marked testicular damage and significantly decreased (P<0.05) sperm cell motility and significantly increased sperm cell abnormalities. Hyperlipidemic low and high dose groups exhibited moderate and complete regeneration of testicular histo-architecture respectively. Furthermore, high dose treated group showed a significant decrease in sperm count, motility, LH and FSH levels. This study suggests that MECLS dose dependently ameliorates testicular damage induced by hyperlipidemia but may affect sperm cell characteristics

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Published

2021-06-30

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Full Length Research Articles

How to Cite

Methanolic extract of Citrullus Lanatus seeds abates testicular degeneration and dose-dependently modulates testicular function in hyperlipidemic male Wistar rats. (2021). Nigerian Journal of Physiological Sciences, 36(1), 101-107. https://ojshostng.com/index.php/njphysiologicalsciences/article/view/1946