Cardio-respiratory and haematological indices in factory workers exposed to cement dust
DOI:
https://doi.org/10.54548/الملخص
The Nigerian cement industry, which produces 58.9 million metric tonnes annually, creates occupational health risks for workers who regularly encounter cement dust containing fine particulates with crystalline silica and heavy metals. This study aims to investigate the effect of cement dust on cardio-respiratory and haematological indices in exposed factory workers. The research design utilized a cross-sectional approach on 111 participants (60 cement factory workers (53 male, 7 female) who had at least three years of exposure and 51 control subjects (44 male, 7 female), matched by demographic characteristics and unexposed to cement dust. Pulmonary function was assessed via spirometry, cardiovascular health was evaluated using electrocardiography and measurement of blood pressure by a digital sphygmomanometer, and a haematological analysis (full blood count) was carried out using standard methods. The study data demonstrated that exposed workers experienced significant decreases in forced vital capacity (FVC), forced expiratory volume in one second (FEV1), Forced Expiratory Flow at 75% of FVC (FEF75), and peak expiratory flow, which point towards restrictive pulmonary damage. The cardiovascular evaluations revealed elevated systolic blood pressure, along with prolonged QTc intervals and reduced T-wave amplitudes. Simultaneously, the haematological assessments revealed increased red cell distribution width and changes in white blood cell counts. The results demonstrate the occupational risk factors (marked declines in lung function, disruptions in cardiac indices, and haematological abnormalities) associated with cement dust contact, highlighting the necessity for stronger industrial regulations with protective measures
المراجع
1. Ahmad, R. and Akhter, Q. (2018). Effects of exposure to cement dust on hemoglobin concentration and total count of RBC in cement factory workers. J. Bangladesh Soc. Physiol. 13: 68-72.
2. Akhter, M., Noor, N., Begum, M., Akhter, S. and Datta, A. (2021). Effect of exposure to cement dust on peak expiratory flow rate of cement factory workers. J. Chittagong Med. Coll. Teach. Assoc. 32: 72-77.
3. Al-Neaimi, Y. I., Gomes, J. and Lloyd, O. L. (2001). Respiratory illnesses and ventilatory function among workers at a cement factory in a rapidly developing country. Occup. Med. (Lond.). 51: 367-373.
4. Al-Shamery, H. and Jankeer, M. (2021). Study the effect of cement dust exposure on the hematological variables in the workers of new Badoosh cement factory in Mosul city, Iraq. J. Phys. Conf. Ser. 1999: 012030.
5. Alter, P., Watz, H., Kahnert, K., Rabe, K. F., Biertz, F., Fischer, R. et al. (2019). Effects of airway obstruction and hyperinflation on electrocardiographic axes in COPD. Respir. Res. 20: 61.
6. Aro, A. L., Anttonen, O., Tikkanen, J. T., Junttila, M. J., Kerola, T., Rissanen, H. A. et al. (2012). Prevalence and prognostic significance of T-wave inversions in right precordial leads of a 12-lead electrocardiogram in middle-aged subjects. Circulation. 125: 2572-2577.
7. Aweto, H. A., Tella, B. A. and Lateef, A. I. (2018). Work-related respiratory symptoms and cardiopulmonary function impairment of factory workers in a cement company in South-West Nigeria. Afr. J. Med. Health Sci. 17: 47-53.
8. Baoum, S. O., Matrafi, T. M. A., Alshaikh, T. T., Alluhaibi, H. N., Alkhaldi, G. N., Alotaibi, M. H. et al. (2022). Common electrocardiogram manifestations in electrolyte imbalance. Int. J. Community Med. Public Health. 9: 3902-3906.
9. Bazett, H. C. (1997). An analysis of the time-relations of electrocardiograms. Ann. Noninvasive Electrocardiol. 2: 177-194.
10. Bhatt, S. P. and Dransfield, M. T. (2013). Chronic obstructive pulmonary disease and cardiovascular disease. Transl. Res. 162: 237-251.
11. Cai, C., Huang, J., Lin, Y., Miao, W., Chen, P., Chen, X. et al. (2019). Particulate matter 2.5 induced arrhythmogenesis mediated by TRPC3 in human induced pluripotent stem cell-derived cardiomyocytes. Arch. Toxicol. 93: 1009-1020.
12. Chen, Z., Ma, J., Lei, J., Li, Y., Zhao, R. and Zhao, L. (2024). Fixed airflow obstruction in asthma can be identified early by low FEF25-75% and is associated with environmental exposure. J. Asthma Allergy. 17: 1001-1014.
13. Churg, A., Wright, J. L., Wiggs, B., Paré, P. D. and Lazar, N. (1985). Small airways disease and mineral dust exposure. Am. Rev. Respir. Dis. 131: 139-143.
14. Cubeddu, L. X. (2003). QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs. Am. J. Ther. 10: 452-457.
15. DeLoughery, T. G. (2014). Microcytic anemia. N. Engl. J. Med. 371: 1324-1331.
16. Dilaveris, P., Antoniou, C. K., Gatzoulis, K. and Tousoulis, D. (2017). T wave axis deviation and QRS-T angle – controversial indicators of incident coronary heart events. J. Electrocardiol. 50: 466-475.
17. Dushyant, K., Walia, G. K. and Devasenapathy, N. (2023). Lung function and respiratory morbidity among informal workers exposed to cement dust: A comparative cross-sectional study. Ann. Glob. Health. 89: 47.
18. Dyer, C. (2012). The interaction of ageing and lung disease. Chron. Respir. Dis. 9: 63-67.
19. Ebong, I. A., Goff, D. C. Jr, Rodriguez, C. J., Chen, H. and Bertoni, A. G. (2014). Mechanisms of heart failure in obesity. Obes. Res. Clin. Pract. 8: e540-e548.
20. Emmanuel, T., Ibiam, U., Okaka, A. and Alabi, O. (2015). Effects of cement dust on the hematological parameters in Obajana cement factory workers. Eur. Sci. J. 11.
21. Etim, M.-A., Babaremu, K., Lazarus, J. and Omole, D. (2021). Health risk and environmental assessment of cement production in Nigeria. Atmosphere. 12: 1111.
22. Farheen, A., Hazari, M. A. H., Khatoon, F., Sultana, F. and Qudsiya, S. M. (2017). Hematological parameters are acutely affected by cement dust exposure in construction workers. Ann. Med. Physiol. 1: 31-35.
23. Hall, N. B., Myers, N. T., Reynolds, L. E., Blackley, D. J. and Laney, A. S. (2024). Women in coal mining – radiographic findings of women participants in the coal workers' health surveillance program 1970-2022. J. Womens Health (Larchmt). 33: 1219-1223.
24. Hill, B. G., Rood, B., Ribble, A. and Haberzettl, P. (2021). Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance. Am. J. Physiol. Heart Circ. Physiol. 320: H1836-H1850.
25. Hogg, J. C., Paré, P. D. and Hackett, T. L. (2017). The contribution of small airway obstruction to the pathogenesis of COPD. Physiol. Rev. 97: 529-552.
26. Jin, Q., Yao, C., Bian, Y. and Pi, J. (2022). Pb-induced eryptosis may provoke thrombosis prior to hemolysis. Int. J. Mol. Sci. 23: 7008.
27. Leigh, J. A., O'Neal, W. T. and Soliman, E. Z. (2016). Electrocardiographic left ventricular hypertrophy as a predictor of cardiovascular disease independent of left ventricular anatomy in subjects aged ≥65 years. Am. J. Cardiol. 117: 1831-1835.
28. Li, Y., Yu, B., Yin, L., Li, X. and Nima, Q. (2024). Long-term exposure to particulate matter is associated with elevated blood pressure: Evidence from the Chinese plateau area. J. Glob. Health. 14: 04039.
29. Malik, M. and Hnatkova, K. (2020). QT interval duration and QT/heart rate relationship. In: Malik, M. and Camm, A. J. (eds.) Dynamic Electrocardiography. 2nd ed. London: Elsevier. pp. 163-182.
30. Mall, M. A. (2016). Unplugging mucus in cystic fibrosis and chronic obstructive pulmonary disease. Ann. Am. Thorac. Soc. 13 Suppl. 2: S177-S185.
31. Meo, S. A. (2004). Health hazards of cement dust. Saudi Med. J. 25: 1153-1159.
32. Mwaiselage, J., Bråtveit, M., Moen, B. and Mashalla, Y. (2004). Cement dust exposure and ventilatory function impairment: an exposure-response study. J. Occup. Environ. Med. 46: 658-667.
33. Nku, C. O., Peters, E. J., Eshiet, A. I., Oku, O. and Osim, E. E. (2005). Lung function, oxygen saturation, and symptoms among street sweepers in Calabar, Nigeria. Niger. J. Physiol. Sci. 20: 79-84.
34. Nordby, K. C., Fell, A. K., Notø, H., Eduard, W., Skogstad, M., Thomassen, Y. et al. (2011). Exposure to thoracic dust, airway symptoms and lung function in cement production workers. Eur. Respir. J. 38: 1278-1286.
35. Obaji-Ogar, L. T., Nsonwu-Anyanwu, A. C. and Odum, F. A. (2020). Oxidative DNA damage and pro-inflammatory response in chronic exposure to cement dust. Asia Pac. J. Med. Toxicol. 9: 3-10.
36. Ogunbileje, J. O., Nawgiri, R. S., Anetor, J. I., Akinosun, O. M., Farombi, E. O. and Okorodudu, A. O. (2014). Particles internalization, oxidative stress, apoptosis and pro-inflammatory cytokines in alveolar macrophages exposed to cement dust. Environ. Toxicol. Pharmacol. 37: 1060-1070.
37. Omidianidost, A., Gharavandi, S., Azari, M. R., Hashemian, A. H., Ghasemkhani, M., Rajati, F. et al. (2019). Occupational exposure to respirable dust, crystalline silica and its pulmonary effects among workers of a cement factory in Kermanshah, Iran. Tanaffos. 18: 157-162.
38. Pan, C., Yan, M., Jin, H., Guo, H. and Han, X. (2021). Chronic exposure to MC-LR increases the risks of microcytic anemia: Evidence from human and mice. Environ. Pollut. 288: 117966.
39. Peters, J. L., Perry, M. J., McNeely, E., Wright, R. O., Heiger-Bernays, W. and Weuve, J. (2021). The association of cadmium and lead exposures with red cell distribution width. PLoS One. 16: e0245173.
40. Priya, S. and Suja, S. (2012). The effect of cement dust exposure on hematological and cytogenetic studies of cement workers. Res. J. Pharm. Biol. Chem. Sci. 3: 615-620.
41. Rahmani, A. H., Almatroudi, A., Babiker, A. Y., Khan, A. A. and Alsahly, M. A. (2018). Effect of exposure to cement dust among the workers: An evaluation of health related complications. Open Access Maced. J. Med. Sci. 6: 1159-1162.
42. Rampon, K. (2023). Anemia: microcytic anemia. FP Essent. 530: 12-16.
43. Rautaharju, P. M., Kooperberg, C., Larson, J. C. and LaCroix, A. (2006). Electrocardiographic predictors of incident congestive heart failure and all-cause mortality in postmenopausal women: the Women’s Health Initiative. Circulation. 113: 481-489.
44. Seko, Y., Kato, T., Yamaji, Y., Haruna, Y., Nakane, E., Haruna, T. et al. (2021). Clinical impact of left and right axis deviations with narrow QRS complex on 3-year outcomes in a hospital-based population in Japan. Sci. Rep. 11: 8892.
45. Shanshal, S. A. and Al-Qazaz, H. K. (2021). Consequences of cement dust exposure on pulmonary function in cement factory workers. Am. J. Ind. Med. 64: 192-197.
46. Thavaraputta, S., Dennis, J. A., Ball, S., Laoveeravat, P. and Nugent, K. (2020). Relation of hematologic inflammatory markers and obesity in otherwise healthy participants in the National Health and Nutrition Examination Survey, 2011-2016. Proc. (Bayl. Univ. Med. Cent.). 34: 17-21.
47. Thomas, E., Guppy, M., Straus, S., Bell, K. and Glasziou, P. (2019). Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies. BMJ Open. 9: e028150.
48. Variste, J., Dowling, M. M. and Quinn, C. T. (2008). Daytime steady-state hemoglobin saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anemia. Blood. 112: 1424.
49. Zhao, Y. and Lv, J. (2018). Basophilic stippling and chronic lead poisoning. Turk. J. Haematol. 35: 298-299.
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