Effect of Hibiscus Sabdariffa (Linn) Water Extract on the Pharmacokinetics of Lisinopril in Healthy Human Volunteers

Authors

  • I. NASIR
  • M. AMINU
  • A. M. ISMAIL
  • R. B. OLOYEDE
  • A. SALISU

DOI:

https://doi.org/10.4314/

Keywords:

Lisinopril, Hibiscus sabdariffa, Pharmacokinetics, Human volunteers

Abstract

Background: The concurrent use of Hibiscus sabdariffa and drugs for the treatment of various ailments is a common practice amongst patients; a practice that could result in drug-herb interaction.

Objective: To evaluate the effects of Hibiscus sabdariffa water extract on the pharmacokinetics of lisinopril.

Methodology: The study involved 24 apparently healthy humans randomly selected and divided into two groups of 12 each. Study was carried out in four phases as crossover study with a washout period of two weeks between the phases; Group 1 (received lisinopril 10 mg alone), group 2 (received lisinopril 10 mg with 200 mL Hibiscus sabdariffa calyxes water extract (25 mg/mL) concurrently), group 2 (received lisinopril 30 min after administration of Hibiscus sabdariffa water extract) and group 1 (received Hibiscus sabdariffa water extract 30 minutes after administration of lisinopril). Saliva samples collected at 0.5 to 36.0 hr in each phase were analysed for lisinopril content using a developed and validated RP-HPLC method. Results were analysed using one-way Anova followed by Tukey’s post Hoc.

Results: Lisinopril administered alone (group 1) achieved Cmax of 95.36 ng/mL at 7 hr (Tmax). Slight increases in Cmax of lisinopril were observed when the drug was interacted with Hibiscus sabdariffa in groups 2 (97.50 ng/mL), 3 (97.37 ng/mL) and 4 (99.24 ng/mL) respectively. The of lisinopril alone was 736805.83 ng.hr/mL. The corresponding for group 2, 3 and 4 are 800409.29, 816866.47, and 10450.03 ng.hr/mL respectively. However, these increases in Cmax and  seen were not statistically significant (p < 0.05). Pharmacokinetic parameters were computed using Kinetica software.

Conclusion: Hibiscus sabdariffa calyxes water extract (200 mL of 25 mg/mL) does not significantly affect the pharmacokinetics of lisinopril in healthy humans.

Mean saliva concentrations of lisinopril Vs time for all the phases of the study

Downloads

Published

2024-07-09

Issue

Section

Full Length Articles

How to Cite

Effect of Hibiscus Sabdariffa (Linn) Water Extract on the Pharmacokinetics of Lisinopril in Healthy Human Volunteers. (2024). Nigerian Journal of Pharmaceutical Research, 20(1), 69-77. https://doi.org/10.4314/

Similar Articles

You may also start an advanced similarity search for this article.