Апстракт
Microbial infections still account for considerable morbidity and mortality in sub-Saharan Africa. The importance of chemotherapeutic agents cannot be over-emphasized. Some antimicrobial agents provide broad spectrum of activity spanning different classes of bacterial and protozoan diseases. Cotrimoxazole, an antifolate antimicrobial was originally meant for treatment of bacterial diseases but has been shown to be an effective drug in the treatment of malaria amongst other conditions. This review attempted to explore the pharmacology of cotrimoxazole, its many clinical uses and adverse effects. Specific experiences of the author in the application of cotrimoxazole in the treatment of acute uncomplicated falciparum malaria were highlighted and suggestions on how to optimize the use of this drug were made.
Keywords: Chemotherapeutic agents, cotrimoxazole, antifolate, uncomplicated falciparum
Résumé
Les infections microbiennes s’estiment èlevèespour une souffrance et mortalitè considèrable dans le sud duSaharan en Afrique . L’importance des agents chimiotherapeutiques sontd’ une grande importance. Certains agents antimicrobiens ont un spectre d’activitèlarge controllant differentes classes des maladiesbactèriennes etprotozoaires. Le cotrimoxazole, unantifolique et antimicrobien ètait originallement dèployè pour le traitement des maladies bacteriennes mais a ètè demontrè comme un medicament efficace dans le traitement du paludisme parmi d’autres conditions. Cette rèvue explore la pharmacologie du cotrimoxazole, ses diverses usages cliniques et ses effects indèsirables. Les experiences specifiques de l’auteur dans l’application ducotrimoxazole dans le traitement du paludisme au falciparum aigue etaient illuminees et les suggestions sur commentoptimiser l’utilitè de ce medicament faites.
Correspondence: Dr. F.A. Fehintola, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigerian. E-mail: fentolamine @yahoo.com.
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