Resumo
Bone tumours are relatively rare compared to tumours of other sites. The frequency of primary malignant bone tumours is low in our environment, as was observed in an earlier study. The aim of this study is to update the information available on the pattern of primary malignant bone tumours at the University College Hospital (UCH), Ibadan, Nigeria. The medical records of 49 patients with malignant bone tumours documented in the Cancer Registry of UCH, Ibadan between January 2001 and September 2007 were reviewed retrospectively. The results were then added to those of the previous study published in 2002. This brought the number of cases of primary malignant bone tumours to 163 from January 1977 to September 2007. Primary malignant bone tumours represented 0.53% of the 30462 cases of cancer seen in the hospital in the period studied. The male female ratio was 1.5:1. About 44% of the tumours occurred among patients less than 20 years of age. Osteogenic sarcoma was the commonest malignant bone tumour. Important changes recorded in the seven years since the last review from this centre include; a rise in the prevalence rate of primary malignant bone tumours (49 new cases in the last seven years as compared to 114 cases over 23 years), the male-female ratio of Osteogenic sarcoma showed a decline (1.5:1 as compared to 1.6:1), and there was an increase in the prevalence of primary malignant bone tumours in the 0-9 years and > 60 years age groups. The significance of these findings will need to be determined by further studies.
Keywords: Bone, neoplasm, malignant, pathology, Ibadan.
Résumé
Les tumeurs osseuses sont relativement rare comparé aux tumeurs des autres organes.La fréquence des tumeurs osseuses primaire mortelles est faible dans notre environment, tel qu’était observé dans une précedente étude. Le but de cette étude est d’actualiser l’ information disponible sur un modéle de tumeurs osseuses primaires mortelle au centre hospitalier universitaire,UCH, Ibadan, Nigeria. Le rapport médical de 49 patients des tumeurs osseuse mortelle documenté dans le régistre de cancer de UCH Ibadan entre janvier 2001 et septembre 2007 étaient rétrospectivement révu. Les résultats étaient alors ajoutés a ceux de l’etude précedente publiée en 2002. Ceci a amené le nombre de cas de tumeur osseuse primaire á 163 patients, de janvier 1977 á septembre 2007. Les tumeurs osseuse primaire mortelle representaient 0.53% des 30462 cas de cancer vue á l’hospital pendant la période d’étude. Le rapport male/femelle était 1.5/1 environ 44 de tumeurs existe parmis les patients de moins de 20 ans. Le sarcome ostéogénique etait la tumeur osseuse mortelle la plus commune. Les changements important rapporté en sept ans depuis la derniére révue de ce centre inclue, l’augmentation du taux de prévalence des tumeurs osseuse primaire mortelle, 49 nouveaux cas dans les sept derniéres années comparé aux 114 cas il y a 23 ans. Les proportions de male/femelle ayant le sarcome ostéogénique ont montré une chute de 1.5/1 á 1.6/1 et il y avait une augmentation de la prévalence des tumeurs osseuses primaire mortelle chez les groupes de 0 á 9ans et plus de 60ans. L’importance de ces découvertes sera á explorer dans les études futures.
Correspondence: Dr. Bade Omololu, Department of Orthopedics and Trauma, University College Hospital, University of Ibadan, Ibadan, Nigeria. Email: bade57@gmail.com
Referências
Omololu BO, Ogunbiyi JO, Alonge TO, Ogunlade SO, Adebisi A and Akang EE. Epidemiology of primary malignant bone tumours in Ibadan (1977-1997). West Afr J Med 2002 21 (4); 291-293.
Yeole BB and Jussawalla DJ. Descriptive epidemiology of bone cancer in Greater Bombay. Indian J Cancer 1998; 35(3):101-106.
Devita VT, Hellman S and Rosenberg SA (eds). Cancer: Principles and Practice of Oncology. 4th Edition.J B Lippincott Company, Philadelphia,1993:1509.
The National Board of Health and Welfare. Cancer incidence in Sweden, 1959-1965. Stockholm, The Cancer Registry, 1971.
Yaw KM. Pediatric bone tumours. Semin Surg Oncol 1999 16(2):173-183.
Akang EEU. Tumours of childhood in Ibadan, Nigeria (1973-1990). Pediatr Pathol Lab Med 1996;16:791-800.
Ojesina AI, Akang EE and Ojemakinde KO. Decline in the frequency of Burkitt’s lymphoma relative to other childhood malignancies in Ibadan, Nigeria. Ann Trop Paediatr 2002 Jun; 22(2):159-163.
Price CHG: Osteogenic Sarcoma; An analysis of age and sex incidence. Brit. Journal of Cancer, 1955, 9:558-574.
Oyemade GA and Junaid TA: Clinicopathological Features of osteogenic sarcoma in Ibadan. Int Surg. 1982: 67: 553-555.
Campanacci M, Giunti A and Olmi R. Giant Cell tomours of bone, A study of 209 cases with long term follow-up in 130. Ital J Orthop Traumatol 1975;1: 249-277.
Sung HW, Kuo DP, Shu WP, et al. Giant cell tumour of bone. Analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg (Am) 1982; 64:755-761.
Junaid TA and Babalola BO. Ibadan Cancer Registry, 1960-1984. In Parkin DM, Stiller CA, Draper GJ, Bieber CA, Terracini B, Young JL (eds). International Incidence of Childhood cancer, Lyon, IARC Scientific Publications, No 87, 1988:37-41
Thomas JO and Aghadiuno PU. Ibadan Cancer Registry, 1985-1992. In Parkin DM, Kramarova E, Draper GJ, et al (eds)International Incidence of Childhood cancer, vol II, Lyon IARC Scientific Publications, No 144,1998:43-45.
Parkin DM, Shanmugaratnam K. Sobin L, Ferlay J and Whelan SL. Histological groups for comparative studies. IARC. Technical Report No 31. Lyon, IRRC, 1998:7.
Dorfman HD and Czerniak B. Bone Cancers. Cancer 1995, 75(1 Suppl):203-210.