Resumo
Among infants with maternally transmitted human immunodeficiency virus (HIV) infection there may be rapid progression of disease especially when infected at an early stage of development, resulting in the onset of severe immunodeficiency and clinical disease soon after birth. This is a case report of six neonates who fulfilled the WHO criteria for presumptive diagnosis of severe HIV disease based on the presence of some clinical signs and symptoms. Cases 1 and 6 had severe wasting and severe sepsis, case 2 had severe wasting, oral thrush and severe sepsis, case 3 had severe pneumonia, oral thrush and severe sepsis, case 4 had severe pneumonia and severe sepsis, while case 5 had severe wasting and oropharyngeal thrush. DNA polymerase chain reaction (PCR) was positive in cases 5 and 6. Where HIV virologic studies are largely unavailable, clinical and immunologic criteria can be used for a presumptive diagnosis of severe HIV infection in children younger than 18 months.
Keywords: Severe HIV disease, neonates, presumptive diagnosis.
Résumé
Parmis les enfants atteints de l’infection du Virus Immunodéficience Humaine (VIH) transmis maternellement, il peut avoir progression rapide de la maladie surtout quant l’on est infecte en debut de developpement, resultant d’une immunodeficience severe et bientot d’une maladie clinique apres la naissance. Ceci est un cas rapporte de 6 nouveau nees qui ont remplis les criteres de l’OMS pour le diagnostique presumptif du VIH severe base sur la presence de certains signes cliniques et symptomes. Les cas 1 et 6 avaient une perte sévère et une septicémie grave, le cas 2 avait une perte sévere, les aphtes, et une septicémie grave, le cas 3 avait une pneumonie sévere, les aphtes et une septicémie grave, le cas 4 avait une pneumonie sévere et une septicemie grave, alors que le cas 5 avait une perte sévere.. La réaction chaine polymérase (PCR) d’ADN était positif chez les cas 5 et 6. Ou les examens virologiques de VIH sont largement indisponibles, les critères cliniques et immunologiques peuvent etre utilisés pour les diagnostiques présomptifs de l’infection de VIH sévere sur les enfants de moins de 18 ans
Correspondence: Dr. R.O. Ugwu, Department of Paediatrics, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. E-mail: rossaire2003@yahoo.com
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