Abstrakt
Breast cancer is one of the most common malignancies that occurs in women. Most of the studies done on breast cancer in our setting are epidemiological. This study aims at determining the histopathological subtypes and various features of breast malignancies seen in our setting. The bench record books of the Department of Pathology, Federal Medical Centre Gombe were used to identify all the breast cancer cases seen from May 2000 to May 2007, after which the Haematoxylin and Eosin-stained slides and request forms were retrieved. The slides were reviewed based on the 2003 WHO classification of breast tumours.One hundred and thirty four breast cancer cases were reviewed histologically. Invasive ductal carcinoma (NOS) made up 66.6%(89/134), followed by invasive lobular carcinoma which comprised 9.7%(13/134). Medullary carcinoma was seen in 6.0%(8/134). Invasive papillary and sarcomatoid carcinomas comprised 3.0%(4/134) each. Invasive ductal carcinomas were graded as follows: grade I – 12%, grade II – 22.5%, and grade III – 65%. The majority of breast cancer cases occurred in the fourth and fifth decades of life.Invasive ductal carcinoma remains the most frequent histopathological subtype and most of the patients in this environment have grade III disease.
Keywords: Breast malignancies; invasive ductal carcinoma
Résumé
Le cancer du sein est l’une des maladies les plus communes qui survient chez les femmes. La plupart des études faites sur le cancer de sein dans notre cadre sont épidémiologiques. Cet étude a pour but de déterminer les sous types histologiques et les différentes caractéristiques. Les registres pris audépartement de pathologie, centre Médical Fédéral de Gombe étaient utilisé pour identifier tous les cas de cancer de sein observe de Mai 2000 - Mai 2007, après lequel les teinture de l’hématoxyline et d’éosine des lames. Les lames épaisses étaient revues selon la classification de l’OMS de 2003 sur les tumeurs du sein. Cent trente quatre cas de cancer du sein étaient histologiquement revues. Le carcinome invasive (NOS) faisait 66.6% (89/134), suivi du carcinome lobulaire invasive qui comprend 9.7% (13/134). Le carcinome médullaire était observe a 6.0% (8/134). Les carcinomes papillaires et sarcomatoide comprenaient 3.0% (8/134) chacun. Les carcinomes étaient classés tel qui suit: classe I- 12%, classe II- 22.5%, et classe III65%. La majorité des cas de cancer du sein survenait entre 40 et 50 ans. Le carcinome reste le sous type histopathologique le plus fréquent et la plupart des patients dans cet environnement ont un mal de classe III.
Correspondence: Dr. Ahmed A. Mayun, Department of Pathology, University of Maiduguri Teaching Hospital, PMB 1414, Maiduguri, Nigeria. E-mail: ahmadumayun@yahoo.com
Bibliografia
Kumar V, Abbas AK and Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th Ed, Philadelphia, Saunders 2004; 1120–1152
Mayun AA, Pindiga UH and Babayo UD. Pattern of histopathological diagnosis of breast lesions in Gombe, Nigeria. Nig J Med. 2008; 17(2): 159–162
Venkitaraman AR. Cancer susceptibility and the function of BRCA1 and BRCA2. Cell. 2002: 108: 171 - 173
Miller K. Estrogen and DNA damage: the silent source of breast cancer. J Natl Cancer Inst. 2003; 95: 100 – 104
Oluwole SF, Fadiran OA and Odesanmi WO. Diseases of the breast in Nigeria. Br J Surg. 1987; 74(7): 582 – 585
Siddiqui MS, Kayuri N, Gill MS et al. Breast disease: a histopathological analysis of 3279 cases at a tertiary care centre in Pakistan. J Pakistan Med Assoc. 2003; 53(3): 94 – 97
Dogo D, Pindiga UH and Yawe T. Pattern of breast lesions in North-Eastern Nigeria. Trop J Med Res. 2000; 4(1): 14 – 17
Mandong BM, Obekpa PO and Orkar KS. Histopathological pattern of breast diseases in Jos, Nigeria. Niger Postgrad Med J. 1998; 5(4): 167 – 170
Out AA, Ekanem I, Khalil PMI, Attah Ed B’ and Ekpo MD. Characterization of breast cancer subgroups in an African population. Br J Surg. 1989; 77: 1182 – 1184
Bloom HJG and Richardson WW. Histological grading and prognosis in breast cancer. Br J Cancer 1957; 11: 359 – 377
Page DL and Anderson TJ. Diagnostic histopathology of the breast. London, Churchill Livingstone, 1987: 193 268
Bloom HJG and Field JR. Impact of tumour grade and host resistance on survival of women with breast cancer. Cancer 1971; 28: 1580 – 1589
American Joint Committee on Cancer. Cancer staging manual , 6th Ed, New York, Springer 2002
Mirza AN, Mirza NQ, Vlastos G and Singletary SE. Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years. Ann Surg. 2001; 10: 235 – 238
Simpson JE and Page DL. Prognostic value of histopathology in breast. Semin Oncol. 1992; 19: 254 – 256
Miller WR and Anderson TT. Oestrogen and progesterone and the breast. In: The menopause. London, Blackwell publishers; 1998: 234-246