Built environment and cancers – Are our homes safe?

Résumé

In Nigeria, some of the environmental factors that may predispose to cancer risk are- unsafe water supplies, untreated sewage, sullage, industrial effluents and emissions. Household hazardous wastes (e.g. batteries, paints, Cytotoxic / genotoxic drugs, etc.), use of cooking fuels (e.g. firewood, charcoal and kerosene), roasted foods, and diesel/petrol generators contribute to cancer causing chemicals particularly polycyclic aromatic hydrocarbons (PAH), benzene derived byproducts, heavy metals etc. in the immediate vicinity of the households irrespective of socioeconomic status of the population. These agents spread the cancer causing chemicals into the environment both outer and built environment. Other emerging issues are the water disinfectant chemicals, arsenic, hormones and drug residues, PAH, dioxins and furans which are proven carcinogens. In addition, leachates (liquid effluents) from the waste dumpsites find their way into terrestrial and aquatic ecosystems and return to human body through food chain. Ecosystems are degraded resulting in biodiversity loss and bioaccumulation of toxic substances. In Niger Delta region, oil spillage and gas flaring activities have been causing morbidity among women and children. Changing lifestyle also plays a role in cancer increase as evident from colorectal cancers. Cancer of the lung, skin, and prostate were more reported from Niger Delta region than other areas in south-west. More evidence is shifting towards the environment as a major cause in cancer incidence. The Nations’ tertiary Institutions lack adequate facilities to detect some of the environmental chemicals which may be suspected carcinogens. There is need to strengthen Research & Development activities in Environmental Toxicology and move ahead in line with the emerging environmental threats to health particularly, cancers.

Keywords: Cancer, built environment, water, polycyclic aromatic hydrocarbons, carcinogens, waste management

Résumé
Au Nigeria, certains facteurs environnementaux prédisposant les risques du cancer inclus la qualité de l’eau, les eaux usées, les émissions industrielles. Les déchets domestiques (batteries, peintures, médicaments cytotoxiques / génotoxiques, etc.), usage des gaz a chauffage (bois, charbon et pétrole), Les aliments fumes et les générateurs a diesel/essence contribuent au cancer particulièrement les hydrocarbonés polycyclique aromatisées tels que les produits dérivé du benzène et les métaux lourds dans notre environnement mis a part le statut socioéconomique de la population. Ces substances augmentent l’incidence du cancer dans notre environnement. D’autres issues émergeant incluent les désinfectants chimiques, arsénite, les résidus des hormones et des médicaments, dioxine et les furanes qui sont démontrés carcinogeniques. En plus, les liquides effluents dans les sites de dépôt d’ordures entrainé dans les écosystèmes terrestre et aquatiques et retourne dans le corps humain par la chaine alimentaire. Les écosystèmes sont dégradés résultant une perte de la biodiversité et la bioaccumulation des substances toxiques. Dans la région du Niger Delta, les activités pétrolières continues de causer la souffrance parmi les femmes et les enfants. Changer le style de vie peut aussi augmenter les causes du cancer telque les cancers colorectaux. Le cancer des poumons, de la peau, de la prostate étaient plus reports dans cette région que d’autres régions au sud-ouest. Plus d’évidences est retourné vers l’environnent comme cause majeur de l’incidence du cancer. Les institutions tertiaires nationales manquent les infrastructures adéquates pour détecter les polluants environnementaux suspectes carcinogeniques. Il est nécessaire de supporter les activités de recherche et de développement en toxicologie environnementale et cancer.

Correspondence: Prof. MKC Sridhar, Division of Environmental Health Sciences, Department of EMSEH, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. E-mail: mkcsridhar@yahoo.com

pdf (anglais)

Références

Clayson, DB. Chemical Carcinogenesis, Boston:Little-Brown &Co,1962; pp 1-467.

Adebamowo, CA and Adekunle, OO. Case control study of the epidemiological risk factors of breast cancer in Nigeria. Br. J. Surg. 1999; 86: 665 – 668.

Adebamowo C. Cancer in Nigeria, American Society of Clinical Oncology. April 2007; www.asco.org ; Web site assessed on September 10, 2008; 1.

Manahan SE. Environmental Biochemistry and Toxicology, in Environmental Chemistry, 4th Edition, Brooks/Cole Publishing Company, Monterey, California, USA. 1984; 496-507.

National Institutes of Health. Cancer and The Environment- What You Need to Know What You Can Do, U.S. Department of Health And Human Services, National Cancer Institute, National Institute of Environmental Health Sciences, 2003; pp 1-46.

Liberty Sibanda, Lilian T. Marovatsanga and James J. Pestka. Review of mycotoxin work in sub-Saharan Africa, Food Control, 1997; 8: 21-29.

Morris RD. Drinking water and cancer. Environmental Health Perspectives. 1995; 103 (8): 225-231.

Smith AH, Hopenhayn-Rich C, Nates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, Wood R, Kosnett MJ and Smith MT. Cancer Risks from Arsenic in Drinking Water. Environmental Health Perspectives. 1992; 97: 259-267.

Wu M.M., Kuo T.L., Hwang Y.H. and Chen C.J. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases, Am. J. Epid. 1989; 130 (6): 1123-1132.

Marabini L, Frigerio S, Chiesara E and Radice S. Toxicity evaluation of surface water treated with different disinfectants in HepG2 cells. Water Research, 2006; 40 (2): 267-272.

Pillai SC., Sridhar, MKC and Kasi Viswanath G. A case study of water pollution at Bangalore, Indian Association for Water Pollution Control Technical Annual, 1980; 6 and 7: 1-14.

Gabbita KV, Sridhar MKC. and Pillai SC. What caused Bangalore’s drinking water smell like “DDT”? Water/Engineering & Management, USA. 1985; 132: 18.

Kasim K, Levallois P, Johnson KC, Abdous B, Auger P. and the Canadian Cancer Registries Epidemiology Research Group. Chlorination Disinfection By-products in Drinking Water and Risk of Adult Leukemia in Canada. Am J. Epid. 2006; 163(2): 116-126.

King WD, Marrett LD, and Woolcott CG. Case-Control Study of Colon and Rectal Cancers and Chlorination By-Products in Treated Water. Cancer Epidemiology Biomarkers and prevention, 2000; 9: 813–818.

Cantor KP, Lynch CF, Hildesheim ME, Dosemeci M, Lubin J, Alavanja M. and Craun G. Drinking Water Source and Chlorination Byproducts in Iowa. III Risk of Brain Cancer. American Journal of Epidemiology, 2006; 150 (6): 552 – 560.

ATSDR (Agency for Toxic Substances and Disease Registry). LEAD CAS # 7439-92-1, US Department of Health and Human Services, 2007.

Colls J. Air Pollution: An Introduction. E & FN SPON, London. 1997, pp.1-590.

Gustafson P, Barregard L, Strandberg B and Sallsten G. The impact of domestic wood burning on personal, indoor and outdoor levels of 1,3-butadiene, benzene, formaldehyde and acetaldehyde. J. Environ. Monit. 2007; 9 (1): 23 – 32.

Ramanakumar AV, Parent ME. and Siemiatycki J. Risk of lung cancer from residential heating and cooking fuels in Montreal, Canada. Am. J. Epid. 2007; 165 (6): 634 – 642.

Boffetta P. Human cancer from environmental pollutants: the epidemiological evidence. Mutat Res., 2006; 608 (2): 157 -162.

Eweka AO., Oni AO and Otuaga PO. Smoking: Its Health Effects and Cessation. The Internet Journal of Nutrition and Wellness. 2008; 6: Number 1, 1.

Zielinski JM, Carr Z, Krewski D, and Repacholi M. World Health Organization’s International Radon project. J. Toxicol. Environ Health A. 2006; 69 (7): 759 –769.

Farai IP, Obed RI and Jibiri NN. Soil radioactivity and incidence of cancer in Nigeria.Journal of Environmental Radioactivity. 2006; 90 (1): 29-36.

Chiang KC, and Liao CM. Heavy incense burning in temples promotes exposure risk from airborne PMs and carcinogenic PAHs. Sci. Total Environ., 2006; 372 (1): 64 – 75.

Yang CR, Lin TC and Chang FH. Particle-size distribution and PAH concentrations of incense smoke in a combustion chamber. Environ. Pollu. 2007; 145 (2): 606 –615.

National Institute of Health. Barbecue Meat Chemicals: Grilling and Cancer, Nutrition, 2005; May 31, p.1, www.worldhealth.net/news. Accessed on July 24, 2009.

Adegbehingbe OO, Oginni LM, Adelusola KA and Olabanji JM. Limb salvage surgery in musculoskeletal tumor: current trends in developing countries without customized endoprostheses. Abstract book for UICC World Cancer Congress on bridging the gap: transforming knowledge into action. 2006; 256.

Ademola S A, Ogundoyin OO, and Gana JY. Changing epidemiology of skin cancers in South Western Nigeria – Is this an indication of changing epidemiology in Sub-Saharan Africa? Abstract book for Union Internationale Coutre Cancre (UICC). 2006.

Adekanye AO, Onuora V, and Onawola K. Late presentation with cancer of the prostate in a developing country – the need for education and screening programmes. Abstract book for UICC World Cancer Congress on bridging the gap: transforming knowledge into action, 2006; 80.

Akumabor PN, Aligbe JU and Ukoli FA. Management of prostate cancer among patients presenting with prostatic disease in a single urology practice in Southern Nigeria. Abstract book for UICC World Cancer Congress on bridging the gap: transforming knowledge into action, 2006; 253.

Ademola-Popoola, Owoeye JFA, Folayan EAO, and Adepoju FG. Spectrum of orbito-ocular tumours in Ilorin, Nigeria. Abstract book for UICC World Cancer Congress on bridging the gap: transforming knowledge into action. 2006; 236.

Asuzu M, Olanrewaju O. and Akinwumi OF. Essential community level knowledge about etiology of cancers to ensure their control: a study of female students in secondary schools. Abstract book for UICC World Cancer Congress on Bridging the gap: transforming knowledge into action. 2006; 516.

Asuzu C. and Asuzu M. The knowledge, attitude and practice of self-breast examination among the female students of the University of Ibadan. Abstract book for UICC World Cancer Congress on bridging the gap: transforming knowledge into action. 2006; 524.

Anorlu RI, Rabiu KA, Abudu OO and Ola ER. Cervical cancer screening practices among general practitioners in Lagos – Nigeria. Abstract book for UICC World Cancer Congress on bridging the gap: transforming knowledge into action. 2006; 179.

Liz Carney. Nigeria fears e-waste ‘toxic legacy’, BBC World Service’s Dirty Business, One Minute World News, December 19, 2006, p.1.

USEPA. Persistent Bioaccumulative and Toxic (PBT) Chemical Program Priority PBT Profiles, Dioxins and Furans, Last updated on Tuesday, January 15th, 2008, web sitehttp://www.epa.gov/pbt/ pubs/dioxins.htm, accessed on July 24, 2009.

Elliott P, Eaton N, Shaddick G. and Carter R. Cancer incidence near municipal solid waste incinerators in Great Britain. Part 2: Histopathological and case-note review of primary liver cancer cases, British Journal of Cancer, 2000; 82: 1103–1106. doi:10.1054/bjoc.1999.1046 Published online 3 February 2000, www.bjcancer.com accessed July 24, 2009.

Jibin NN. Assessment of health risk levels associated with terrestrial gamma radiation dose rates in Nigeria, Environment International. 2001; V27 (1): 21-26.

Ana, GREE., Sridhar MKC and Asuzu MC. Environmental risk factors and hospital-based cancer rates in two Nigerian cities, 2009; J. Environmental health, In Press.

Okeagu JC, Adegoke AO. and Onuoha C. The environmental and social impact of petroleum and natural gas exploitation in Nigeria, Journal of Third World Studies, 2006; 1-18.

Friends of the Earth. Behind the Shine - the Real Impacts of Shell’s Work around the World, Archived Press Releases. 2004; Website assessed on September 2008.

Nwankwoala R N P and Georgewill O A. Analysis of the occurrence of cancer and other tumours in Rivers and Bayelsa states, Nigeria from December 1997 – December 2000. African J. Applied Zool. and Environ. Biol.; 2006. 8: 48 – 53.

Nwabueze O. SPDC Proposed Integrated waste management facility site at Umuakuru Igbo Etche, National Environmental Protection Science Association of Nigeria’s (NEPSAN)’s view. A memorandum to public complaint and petition committee, Rivers State House of Assembly. 2000. http://www.steppingstones nigeria.org accessed September 2008

Anon. Environmental Health Perspectives. 1994; 103(3): 102-103.