Abstract
Introduction: The incidence of oral cavity cancer is on the increase. Most cases present late resulting in poor prognosis of the disease. In the last few decades there has been an increasing trend of use of radiotherapy to treat oral cancers with improvement in survival. This retrospective study was aimed at determining the pattern of oral cancers seen at Radiotherapy Department of University College Hospital Ibadan and also to assess outcome of treatments offered over a period of 24 years.
Methodology: Data extraction form was designed to obtain information from case notes and treatment records of patients with histologically diagnosed oral cavity cancer from 1987 to 2011 at the Radiotherapy clinic. The outcome of treatment at 6 months follow up was determined as either complete or partial/ no clinical response. Symptom free interval was also determined for each patient.
Results: A total of 88 patients with histologically diagnosed oral cavity cancer were analysed. The mean age of presentation was 51.8 years with M: F ratio 1.8: 1. The mean duration of symptoms was 13.4 months. All the patients in this study had radiotherapy. Complete clinical response was seen in 35 patients (39.8%) while partial and no response was observed in 53 (60.2%) patients. Patients who had radical doses of radiotherapy, early stage at presentation and multimodality treatment were found to have better outcome.
Conclusion: Oral cancer patients present late in our environment, Radiotherapy in combination with other modalities of treatment have been found to have better outcome.
Keywords - Radiotherapy Management, clinical response, symptom free interval
Résumé
Contexte: L’incidence du cancer de la cavité buccale est en augmentation. La plupart des cas se présentent tardivement, ce qui entraîne un mauvais pronostic de la maladie. Dans les dernières décennies il ya eu une tendance croissante de l’utilisation de la radiothérapie pour traiter les cancers oraux avec une amélioration de survie. Cette étude rétrospective visait à déterminer le schéma des cancers oraux observés au département de radiothérapie du Collège Hospitalier Universitaire d’Ibadan et aussi évaluer les résultats des traitements offerts sur une période de 24 ans.
Méthodologie: Le formulaire d’extraction de données a été conçu pour obtenir des informations à partir des notes de cas et des dossiers de traitement des patients atteints d’un cancer histologique de la cavité buccale de 1987 à 2011 à la clinique de radiothérapie. L’issue du traitement à 6 mois de suivi a été déterminée comme complète ou partielle / pas de réponse clinique. L’intervalle libre de symptômes a également été déterminé pour chaque patient.
Résultats: Un total de 88 patients ayant un cancer histologique de la cavité buccale ont été analysés. L’âge moyen de présentation était de 51,8 ans avec un rapport M:F de 1,8:1. La durée moyenne des symptômes était de 13,4 mois. Tous les patients de cette étude avaient une radiothérapie. Une réponse clinique complète a été observée chez 35 patients (39,8%) alors que la réponse partielle et aucune réponse n’a été observée chez 53 (60,2%) patients. Les patients qui ont reçu des doses radicales de radiothérapie, au stade précoce de la présentation et au traitement multimodal ont été jugés à avoir de meilleurs résultats.
Conclusion: Les patients atteints d’un cancer buccal se présentent tardivement dans notre environnement, la radiothérapie en association avec d’autres modalités de traitement s’est révélée avoir de meilleurs résultats.
Mots-clés - Gestion de la radiothérapie, Cancer buccal, survie
Correspondence: Dr. M. Ali-Gombe, Department of Radiology, College of Medical Sciences, Gombe State University. Gombe E-mail:aligombem@yahoo.com
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