Abstrakt
Background: Leukaemias are haematological malignancies characterized by unregulated clonal proliferation of haematopoietic cells.
Objective: To determine the pattern of childhood leukaemia in Ibadan.
Methodology: This was a retrospective study of leukaemia cases diagnosed at the University College Hospital (UCH), Ibadan between January 1991 and December 2010 in children less than 15 years of age. Data obtained was subjected to statistical analysis using the Statistical Package for Social Sciences version 20.
Results: There were 64 cases of childhood leukaemia, accounting for 10.2% of childhood cancers seen during this study period. The male to female ratio was 2:1 and modal age group was between 10 and 14 years. Thirty (46.9%) cases were acute lymphoblastic leukaemia (ALL), 22 (34.4%) were acute myelogenous leukaemia (AML) and 12 (18.8%) were unspecified acute leukaemias. There was no case of chronic myeloid or lymphocytic leukaemia.
Conclusion: There has been a relative increase in the frequency of leukaemia cases at UCH, Ibadan, which may be largely explained by increased awareness and referrals. There is a need for further collaborative multicentre studies of childhood leukaemias in Nigeria and other developing countries and focused research on childhood leukaemias in order to unravel the aetiology.
Keywords: Childhood leukaemia, Ibadan
Résumé
Introduction: Les leucémies sont des maladies malignes hématologiques caractérisées par la prolifération clonale non réglementée des cellules hématopoïétiques.
Objective: Pour déterminer le modèle de la leucémie d’enfance à Ibadan.
Méthodologie: Ceci était une étude rétrospective des cas de leucémies diagnostiquées au Collège Hospitalier Universitaire (CHU), Ibadan entre Janvier 1991et Décembre 2010 dans les enfants âgés moins de 15 ans. La donnée obtenue était à sujet de l’analyse statistique en utilisant l’Emballage Statistique pour les sciences sociales version 20.
Résultats: Ils y avaient 64 cas de leucémies d’enfance, comptant pour 10,2% de cancers d’enfance vue durant cette période d’étude. Le ratio du male à la femelle était 2 : 1 et le groupe d’âge modal était entre 10 et 14 ans. Trente (46,9%) cas étaient la leucémie lymphatique-balistique aigue (LLA), 22 (34,4%) étaient la leucémie de myélose aigue (LMA) et 12 (18,8%) étaient 12 (18,8%) étaient des leucémies aigues non spécifiées. Il n’y avait pas de cas de leucémie myéloïde ou de lymphocyte chronique.
Conclusion: Il y’a eu une croissance relative dans la fréquence des cas de leucémies au CHU, Ibadan, ce qui peut être largement expliquée par l’accroissement de renseignements et de renvois. Il y a un besoin pour plus d’études collaboratives à multi centres de la leucémie d’enfance au Nigéria et autres pays en voies de développement et des recherches foyer sur la leucémie d’enfance dans le but de démêlé l’étiologie.
Mots clés: Leucémie d’enfance, Ibadan
Correspondence: Dr. G.O. Ogun, Department of Pathology, University College Hospital, PMB 5116, Ibadan, Nigeria.
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