Emergence of Raoultella ornithinolytica as a significant intestinal microbiota in Nigerian Neonates’
Keywords:
Gut microbiota, infection, Neonate, Raoultella ornithinolyticaAbstract
Background: There are increasing reports of Raoultella ornithinolytica infection in humans. This study reports significant contribution of Raoultella ornithinolytica to neonatal gut microbiota.
Methods: Rectal swab samples were collected in 70 healthy neonates, within 6-12hours of birth, and days 3, 9, and 14 after birth. Colonization by R. ornithinolytica was evaluated against neonatal characteristics.
Results: Among the 70 neonates, R. ornithinolytica was the fourth most common bacteria isolated. R. ornithinolytica was part of gut microbiota at birth, and on Day 3, Day 9, and Day 14 after birth in 15%, 28.6%, 21.4% and 5.7% of neonates respectively. No factor was associated with R. ornithinolytica colonization, but a trend towards an increased likelihood of colonization among females, asphyxiated and neonates whose mothers had prolonged labour was observed.
Conclusion: R. ornithinolytica has emerged as an important part of gut microbiota among neonates in Nigeria, but its’ role in neonatal dysbiosis and infection remains unclear.
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