Abstract
Objective: To evaluate the analgesic and anti-inflammatory activities of the methanol extract of Cnestis ferruginea (CF) in rodents.
Materials and Methods: The antinociceptive activity of CF was evaluated using thermal (hot plate and tail flick tests) and chemical (acetic acid induced writhing and formalin tests) methods. The anti-inflammatory effects were studied using the cotton pellet granuloma and carrageenan induced paw edema tests.
Results: The extract (300-500mg/kg, per oral), dissolved in normal saline produced a dose dependent analgesic effect on a hot plate maintained at 55 ± 2°C as well as on the early and late phases of formalin induced paw licking in rats. At the same doses, the plant extract also significantly (p<0.05) inhibited the carrageenan induced paw edema and cotton pellet granuloma formation in rats.
Conclusion: The results suggest that the methanol extract of CF possesses analgesic and anti-inflammatory activities.
Keywords: Cnestis ferruginea, methanol extract, analgesic, anti-inflammatory
Résumé
Objectif: Evaluer les activités analgésiques et anti-inflammatoires de l’extrait au méthanol de Cnestis ferrugineux (FC) chez les rongeurs.
Matériels et méthodes: L’activité anti nociceptive de la CF a été évaluée à l’aide de méthode thermique (plaque hauffante et des tests de mouvement de la queue) et chimique (acide acétique induite en contorsion et des essais de formol). Les effets anti-inflammatoires ont été étudiés en utilisant les tests de granulome des boulettes de coton et de patte œdème induite de carragheen.
Résultats: L’extrait (300-500mg/kg, par voie orale), dissous dans une solution saline normale a produit un effet analgésique à dose dépendant sur une plaque chaude maintenue à 55 ± 2 ° C ainsi que sur les phases précoces et rdives de la patte induite par le formol raclé chez des rat. Aux mêmes doses, l’extrait végétal aussi a significativement (p <0,05) inhibé l’œdème de patte induite par la carragheen et la formation de granulome de boulette de coton chez des rats.
Conclusion: Les résultats suggèrent que l’extrait de méthanol de CF possède des activités analgésiques et antiinflammatoires.
Correspondence: Dr. GF Ibironke, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria. E-mail; gibironk@yahoo.com
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