Comparison of Pregnancy and Neonatal Outcomes Amongst HIV Positive Women and HIV Negative Women at the University College Hospital Ibadan, Nigeria – A Cross-sectional Study

Authors

  • Omobolanle I. Adenmosu
  • Bukola Adesina

Keywords:

HIV, HAART, pregnancy, neonatal, outcomes

Abstract

The effect of Human Immunodeficiency Virus (HIV) and possibly Highly Active Antiretroviral Therapy (HAART) on pregnancy and neonatal outcomes has been a controversial issue with some researches reporting no association while others reporting significant association. This study aimed at comparing the pregnancy and neonatal outcomes between Human Immunodeficiency Virus (HIV) positive women and HIV negative women who delivered at University College Hospital (UCH), Ibadan. This study was a cross-sectional study carried out at the University College Hospital, Ibadan Nigeria. The case notes of all the HIV positive pregnant women and their comparison group who delivered in the year 2013(January 1st- December 31st) were retrieved. Data was summarized with frequency tables and mean (SD). Association between categorical variables was analyzed using chi-square test or Fisher test and association between continuous variables were analyzed using independent T-test. A probability value of <0.05 was considered statistically significant. Compared with the HIV negative women the HIV positive women had higher parity (p<0.001), lesser educational qualifications (p=0.004) and lower occupational positions (p<0.001). The differences for selected pregnancy and neonatal outcomes were not statistically significant; antenatal complications, blood loss at delivery, gestational age at delivery, birthweight of the babies, Apgar score, perinatal death and congenital anomalies. The socio-demographic characteristics were different in both groups and highlight need for programs to address these factors

References

Adejuyigbe, E.A., Fasubaa, O.B., and Onayade, A.A. (2004): Sociodemographic characteristics of HIV- positive mother-child pairs in Ile-Ife, Nigeria. AIDS Care. 16 (3): 275-82.

Adesina, O.A., Michael, O., Ogunbosi, B., Akinyemi, J., Kuti, M., Awolude, O., Fayemiwo, S.A., Adewole, I.F. (2015a): Obstetric and newborn outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women at the University College Hospital, Ibadan. Trop. J. Obstet. Gynaecol. 32(1): 64-74.

Adesina, O.A., Kuti, M., Ogunbosi, B., Akinyemi, J., Fayemiwo, A., Awolude, O., Adewole, I.F. (2015b): An audit of the uptake of key PMTCT interventions in the pre and post WHO rapid advice periods at the University College Hospital, Ibadan. Trop. J. Obstet. Gynaecol. 32(1): 104-112.

Ahmadu, B.U., Mustapha, B., Bappariya, J.I., Alfred, N., Joel, Z.(2013): The effects of weathering demonstrated by maternal age on low birth weight outcome in babies. Ethiop J Health Sci. 23(1): 27-31.

Awofala, A.A., Ogundele, O.E. (2016): HIV epidemiology in Nigeria. Saudi Journal of Biological Sciences. Http://dx.doi.org/10.1016/ j.sjbs.2016.03.006

Brocklehurst, P., and French, R. (1998): The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis. BJOG. 105 (8) 836-48.

European Collaborative Study; Swiss Mother and Child HIV Cohort Study.Combination antiretroviral therapy and duration of pregnancy. (2000): AIDS. 14(18): 2913-20.

Ezeaka,, V.C., Iroha,, E.O, Akinsulie,, A.O., Temiye EO, Adetifa I,M,O. (2009). Anthropometric indices of infants born to HIV-infected mothers: a prospective cohort study in Lagos, Nigeria Int. J STD AIDS. 20 (8). 545-8

Ezechi, O.C., Fasubaa, O.B., Kalu, B.E.K., Nwokoro, C.A., Obiesie LO. (2004): Caesarean Delivery: Why the Aversion? Trop J Obstet Gynaecol 2004; 21: 164-7.

Ezechi, O.C., David, A.N., Gab-Okafor CV, et al. (2012): Incidence of and socio-biologic risk factors for spontaneous preterm birth in HIV positive Nigerian women. BMC Pregnancy Childbirth. 12: 93.

Ezechi, O.C., Gab-Okafor, C.V., Oladele, D.A., Kalejaiye, O.O, Oke BO, Okwodo HO, Adu RA et al (2013). Pregnancy, Obstetric and Neonatal Outcomes in HIV Positive Nigerian Women. Afr. J. Reprod. Health. 17 (3): 160-8.

Fiore, S., Newell, M.L., Trabattoni, D., Thorne, C., Gray, L., Savasi, V., Tibaldi, E., et al.(2006). Antiretroviral therapy-associated modulation of Th1 and Th2 immune responses in HIV-infected pregnant women. J Reprod Immunol. 70(1-2): 143-50.

Frank, R., Pelcastre, B., Salgado, de Snyder, V.N., Frisbie, W.P., Potter, J.E., Bronfman-Pertzovsky, M.N. (2004). Low birth weight in Mexico: new evidence from a multi-site postpartum hospital survey. Salud Publica Mex. 2004; 46(1): 23-31.

Gluckman, P.D., Hanson, M.A., Cooper, C., Thornburg, K.L.(2008). Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 359(1): 61-73.

Habib, N., Daltveit, A., Bergsjo, P., Shao, J., Oneko, O. and Lie, R. (2008), Maternal HIV status and pregnancy outcomes in northeastern Tanzania: a registry-based study. BJOG: An international Journal of Obstetrics & Gynaecology, 115: 616-624.

Haeri, S., Shauer, M., Dale, M., Leslie, J., Baker, A., Saddlemire, S., and Boggess, K. (2009). Obstetric and newborn infant outcomes in human immunodeficiency virus-infected women who receive highly antiretroviral therapy. Am J Obstet Gynaecol. 201 (3): 315.e1-5

Karoline, A.P., Olav, L., Tracy, R.. Glass., Loise, V., Christoph, R., Luigia, E., Mannel, B., Olivia, K., Begona, M. de T, and Irene, H. (2010). Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008. J Perinat Med. 38(4). 353-358.

Kogan. M.D., (1995). Social causes of low birth weight. J R Soc Med. 88(11): 611-5.

Kuhn. L., Aldrovandi, G.M., Sinkala, M., et al.(2008). Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med 2008; 359(2): 130-41.

Mofenson LM (2002); Centers for Disease Control and Prevention USPHSTF. U.S. Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. MMWR Recomm Rep 2002 51(RR-18):(Nov 22;): 1-38.

Onah, H.E, Obi, S.N, Agbata, T.A, and Oguango, T. C. (2007). Pregnancy outcomes in HIV-positive women in Enugu, Nigeria. J Obstet Gynaecol vol. 27, pp 271.

Peng-Lei, X., Qing-Wu, J, Yi-Biao, Z., Yue, C., Xiu-Xia. S., Yan, Shi., (2015). Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies. BMC Pregnancy and Childbirth (2015) 15:246.

Shapiro. R.L., Hughes, M.D., Ogwu, A. et al. (2010). Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med. 362(24): 2282-94.

St John, M.A., Denny, F., and Babb, D. (2015). Outcome of HIV-infected Pregnant Women and Their Offspring in Barbados: A Five-year Study. West Indian Medical Journal. 64 ( 1) 49.

Szyld, E.G, Warley, E.M., and Freimanis, L. (2006). Maternal antiretroviral drugs during pregnancy and infant low birth weight and preterm birth. AIDS. 20 (18): 2345-53.

Tang, J., and Nour, N.M. (2010). HIV and Pregnancy in Resource-Poor Settings. Rev Obstet Gynecol. 3(2) 66-71.

Torres-Arreola, L.P., Constantino-Casas, P., Flores-Hernandez, S., Villa-Barragan, J.P., Rendon-Macias, E.(2005). Socioeconomic factors and low birth weight in Mexico. BMC Public Health. 5: 20.

Townsend, C.L., Cortina-Borja, M., Peckham, C.S., Tookey, P. (2007). An Antiretroviral therapy and premature delivery in diagnosed HIV-infected women in the United Kingdom and Ireland. AIDS. 21 (8) 1019-26.

Tucker, J., McGuire, W (2004): Epidemiology of preterm birth. BMJ. 329(7467): 675-8.

Tyndall, J.V., Okoye, V., Donkene, F., and Kar, S. (2011): Comparing Pregnancy Outcomes in HIV-infected and HIV-uninfected women in Adamawa Stare, Nigeria: a registry based study. International Conference on Medical, Biological & Pharmaceutical Sciences pp. 505.

Van der Merwe, K., Hoffman, R, Black, V., Chersich, M., Coovadia, A., Rees, H. (2011): Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study. J Int AIDS Soc. 1; 14: 42.

Wanda, I., Figueroa-Cosme, Nanet, M., Lopez-Cordova, & Jose, A. Capriles-Quiros (2010): Mothers of Adolescent Girls: comparing HIV Positive and HIV Negative Women. Ethn Dis. 20 (1 suppl 1) S1-271-30 .

World Fact Book (2014): People living with HIV/AIDS. World Health Organization. Rapid Advice: use of anti-retroviral drugs for treating pregnant women and preventing HIV infections in infants 2009.

Yu, L., Li, W.Y., Chen, R.Y., Tang, Z.R., Pang, J., Gui, X.Z., Meng, X.N., Zhang, F., (2012) Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China. Chin Med J (Engl) 2012; 125(3): 403-9.

Published

2020-07-31

How to Cite

Comparison of Pregnancy and Neonatal Outcomes Amongst HIV Positive Women and HIV Negative Women at the University College Hospital Ibadan, Nigeria – A Cross-sectional Study. (2020). African Journal of Biomedical Research, 23(Special Edition 1), 53-57. https://ojshostng.com/index.php/ajbr/article/view/359

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