Ferulic Acid Ester from The Stem Bark of Acacia ataxacantha
Keywords:
Acacia ataxacantha, tetradecanyl ferrulate, protein kinaseAbstract
From the chloroform extract of the stem bark of Acacia ataxacantha, a ferrulic acid derivative identified as n-tetradecanyl-3-methoxy-4-hydroxy –trans-cinnamate (tetradecanyl ferulate) compound 2 was isolated for the first time from this plant alongside the triterpene lupenol. The structure of compound 2 was confirmed using NMR and MS and is reported here for the first time. Primary activity of the isolated compound against a panel of disease related protein kinases reveal the compound to be in-active.
References
Abbas Delazar, Mohammed Shoeb, Yash Kumarasamy, Maureen Byres, Luftun Nahar, Masoud Modarresi and Satyajit D.Sarker (2004). Two bioactive Ferulic acid derivatives from Eremostachys glabra. DARU Vol 12 (2), 49-53
Achenback H., Stocker M., Costenta M. A. (1986). Chemical Investigations of Tropical Medicinal Plants, XXI [1] Long Chain Alkyl Esters of Ferulic and p-Coumaric Acid from Bauhinia manca Zeitschrift fur Naturforschung, 41, 164-168.
Amoussa, AMO; Sanni, A and Lagnika, A (2015). Flavonoids and Flavonol contents of the bark of Acacia ataxacantha. Journ.of Pharmacog. and Phytochem. 4(2), 172-178
Amoussa, AMO; Tchatchedra,M; Lateye, A;A and A Lagnika (2015). Acute toxicity and antifungal effects of Acacia ataxacantha stem bark. Int. Journ. of Pharm& Phytochem.Res. 7(4), 661-668
Amoussa,AMO; L.Lagnika;M.Bourjot;C.V Senecheau and A. Sanni (2016a). Triterpenoids from Acacia ataxacantha DC: antimicrobial and antioxidant activities. BMC comple.Alter.Med. 16, 284.
Amoussa, AMO; L.Lagnika; M.Bourjot; C.V Senecheau and A. Sanni (2016b). New chromone derivative from Acacia ataxacantha and its biological activities. BMC complet.Alter.Med. 16, 506
Ahmadu,A.A; A Agunu; Vassilios Myrianthpoulos and Nikolas Fokialakis (2018). Chemical Constituents of the stem bark of Acacia ataxacantha. Trop. Journ.of Nat. Prod. Res. 2 (8), 380-382
Bach S; Knockaert M; Reinhardt J; Lozach O; Schmitt S; Baratte B; and Koken M (2005). Roscovotine targets, protein kinase and pyridoxal kinase. J. Biol.Chem. 290, 31208-31219
Busse, W (2000).The significance of quality for efficiency and safety control of herbal medicinal products. Drug Inform.Journ. 34(1), 15-23
Buttler,MS (2004).The role of Natural Products for drug discovery. Journ. of Nat. Prod. 67(12), 2141-2153
Calixto,JB(2000).Efficacy, Safety, Quality control and marketing and regulating guidelines for herbal medicines. Braz. Journ.of Biol.Res. 2, 179-189
Capedeville R., Burchdurger E., Zinnermann J., Matter A. (2002). Gilvec (ST1571 Imatinib), A rationally developed target anticancer drug. Nat.Rev Drug Disc 1:493
Ebada,SS; Edrada,RA; Lin W and Proksch,P (2008). Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates. Nature protocols. 3(12), 1820-1831
Harborne J. B. (1998). Phytochemical methods, a guide to modern technique of plant analysis. London. Chapman and Hall Ltd. Pp 49-188
Hollosyl F, and Keri G. (2004). Plant derived protein tyrosine kinase inhibitors as anti-cancer agents. Curr Med Chem. 4 (2), 173-197
Kareji, AE (2013). Evaluation of herbal drugs used to treat fungal and bacterial diseases in Kenya. Int. Journ.of Herb. Med.Plants. 1(4), 85-87
Katiyar, C; Gupta, A; Kanjilal, K and Kantiyar, S (2012). Drug discovery from plant source: An integrated approach. Int.qauterly Journ. of Research in Ayurveda. 33(1), 10
Lahlou, M (2007). Screening of natural products for drug discovery. Drug discovery. 2(5), 697-705
Macdonald, I; Joseph, OE and Harriet, ME (2010). Documentation of the medicinal plants sold in markets in Abeoukuta, Nigeria. Trop.Journ.of Pharm.Res. 9(2), 110-118
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. (2002). The protein kinase complement of the human genome. Science. 298, 1912-1934
Newmann,DJ and Cragg GM (2016).Natural Products as sources of New drugs from 1981-2014. Journ. of Nat.Prod.79, 629-661
Newmann,DJ; Cragg,GM and Snader,KM (2000).The influence of Nat.Products upon drug discovery. Nat.Prod.Rep. 17(3), 215-234
Nkengfack,A.E; Vouffo,T.W; Vardamides,J.C; Kouam,J;Fomum,Z.T; Meyer,M and Styerner,O (1997). Phenolic metabolites from Erythrina species. Phytochem. 46(3), 573-578
Rates,SM (2001). Plant as source of drugs. Toxicon. 39(5), 603-613
Seigler D.S (2003). Phytochemistry of Acacia sensu lato. Biochem.Syst.Ecol. 31, 845-873 Patil RL, Balaraman R (2009). Effect of melatonin on doxorubicin testicular damage in rats. Int J PharmTech Res. 1:879-84.
Wagner, H and Bladt, S (2001). Plant drug analysis, a Thin Layer Chromatography. 2nd edition, Springer –Verlag, New York. P 384..
