Therapeutic Potentials of “Cordyceps Plus” Capsule on Gentamicin Induced Nephrotoxicity in Male Albino Rats

• I.S Akande

Gentamicin is an aminoglycoside antibiotic commonly used for the treatment of Gram-negative bacterial infection, but limited by its nephrotoxic side effects particularly if multiple doses accumulate over a course of treatment. Nephroprotective agents are substances which possess protective activity against Nephrotoxicity. “Cordycep plus” capsule is said to have therapeutic properties due to the presence of various complex chemical substances. To determine the therapeutic effect of “Cordycep plus” Capsule on gentamicin induced Nephrotoxicity. Twenty eight (28) male Sprague-Dawley rats (120 - 150g) were equally divided into four groups: positive control, negative control (untreated), Treatment 1 (300mg/kg body weight of “Cordycep plus” Capsule), and Treatment 2 (600mg/kg body weight “Cordycep plus” Capsule). Nephrotoxicity was induced by intra peritoneal injection of gentamicin for 8days prior to the commencement of treatment. The rats were sacrificed after 4 four weeks of treatment and their blood samples were collected for biochemical assays. The kidneys and livers were harvested for histological assessments. Compared with the positive control group, Gentamicin induction caused a decrease in body weight of the animals, induced nephrotoxicity and the “Cordycep plus” Capsule reduced the toxic effect. The antioxidant levels of GSH, SOD and MDA were significantly (p < 0.05) decreased in the negative control (untreated) group but increased in the “Cordycep plus” treated groups as compared with the positive control (normal) group. Urea, Creatinine, Uric acid, catalase, lipid profile and electrolyte levels were significantly increased (p < 0.05) in the negative control group as compared with the positive control group and the two treated groups. Histopathological examinaton of the morphological structure of the kidney and liver in the treated group showed that nephrotoxicity can be reversed before necrosis. Treatment with 600mg/kg body weight of “Cordycep plus” Capsule had pronounced nephroprotective potentials on gentamicin induced nephrotoxicity, thus “Cordycep plus” capsule has a therapeutic effect only on renal damage before total cell death.

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