Methanol leaf extract of Terminalia superba Engl & Diels (Combretaceae) mitigates chemically induced nociceptive and inflammatory effects in animal models
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Keywords

Terminalia superba
inflammation
nociception
granuloma
pain threshold

Abstract

The effect of methanol extract of T. superba (METs) leaves on nociception and inflammation were investigated in this study. Folk medicine has reported the use of T. superba  in the management of swelling, but scientific evidence of its usage is limited. This study aims to study the nociceptive and anti-inflammatory properties of Terminalia superba . Fifty Sprague Dawley rats of either sex were split into two major groups with five sub-groups (n=5). Each of the major groups was used for formalin and cotton pellet granuloma models. Also, 50 mice divided into 2 major groups of 25 with 5 groups were used for analgesic writhing and thermal response tail-flick tests in mice. 100, 200 and 400 mg/kg were used while diclofenac (10 mg/kg) and morphine (10 mg/kg) served as standard drugs for anti-inflammatory and analgesic investigations respectively. METs at 200 and 400 mg/kg (p < 0.05) inhibited the inflammatory action of the formalin and cotton pellet granuloma significantly, in a manner that is dose-dependent. METs also significantly (p ˂ 0.05) reduced writhing and thermal response. Based on these results, METS have both anti-inflammatory and anti-nociceptive potentials which could explain its folkloric use in the management of swelling.

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