Coronavirus disease 2019 (COVID-19) infection is a multi-organ disease. Reports have shown that elevated activity of lactate dehydrogenase (LDH) is associated with poor outcomes in patients with viral infections. Changes in LDH activity from admission through discharge were determined in patients with SARS-CoV-2 infection with a view to determining its prognostic properties. Serum activity of LDH was determined in sixty COVID-19 patients, at admission and at discharge from the isolation centre, and sixty controls using ELISA. The mean serum LDH activity was significantly higher in COVID-19 patients at admission and at discharge compared with the controls. However, the mean LDH activity was slightly lower in COVID-19 patients at discharge compared with the activity at admission. It could be concluded from the study that LDH activity is elevated in COVID-19 patients and changes in its activity during the course of COVID-19 management could provide clinical information on patient’s response to therapy.