Neurocognitive Impairment in Aging People Living With HIV: A Comparative Study of Elderly Patients Attending the University College Hospital Ibadan, Nigeria
Click to view file (PDF)


PLWH, MCI, Dementia, Elderly, MoCA


Ageing People Living with HIV (PLWH) can experience an exacerbation of age-associated neurocognitive impairment (NCI) and decline compared to their HIV- uninfected counterparts. This study aimed to evaluate age-associated cognitive impairment in ageing PLWH in contrast to age-matched HIV-uninfected older adults. A survey of 186 persons (≥60years) was conducted at the University College Hospital, Ibadan Nigeria between April and June 2018. Participants were selected at a ratio 1:2 for HIV-positive and HIV-negative status respectively, and age-matched at ±5years. The Montreal Cognitive Assessment (MoCA), and Trail Making Test (TMT) A & B were conducted for cognitive assessment and other clinical data were collected and analyzed with SPSS 23. Ageing PLWH, had poorer cognitive ability (p=0.000) and a higher burden of chronic non-communicable diseases (NCDs) (p=0.000). Many (71%) of the PLWH, had cognitive-impairment, with 32 cases of Mild Cognitive Impairment (MCI) and 12 individuals diagnosed with dementia. Of the HIV-infected cohort, the cognitively-impaired, ageing PLWH had higher viral-load and poorer HAARTs-compliance. Risk factors for cognitive impairment among ageing-PLWH were: greater than 8 years duration of HIV-infection (p=0.032) and poor HAARTs-compliance (p=0.039), while type-1 HIV (p=0.057) and higher viral-load (p=0.076) showed a trend towards significance.   Ageing People living with HIV(PLWH) are more at risk of developing early-onset dementia because of HIV-related factors. Early screening for dementia should be recommended as part of HIV-care plan for adult persons living with HIV in low and middle-income countries like Nigeria

Click to view file (PDF)