Sažetak
Background: Trauma has been tagged a modern
international epidemic and the commonest causes
of mortality following polytrauma include severe
infections leading to multiple organ dysfunction
syndrome or multiple organ failure.
Materials and methods: Patients with polytrauma
admitted through the Accident and Emergency
department (now simply referred to as the Emergency
Department) that satisfy the defined criteria were
recruited and had their blood samples taken into an
endotoxin free EDTA bottles at 48 ± 2 hours after
trauma and samples stored at -800 Celsius until
analyzed. Serum MCP-1 level was estimated for each
patient using the Human MCP-1 ELISA kit based
on the manufacturer’s guide. In addition, the Revised
Trauma Score comprising of the Glasgow Coma Scale
Score, Respiratory Rate and Systolic Blood Pressure
at presentation was documented for each patient.
Results: 110 polytrauma patients had their sera
assayed for MCP-1. The patient’s ages ranged from
18 to 80 years. The mean age was 39.98 ± 14.369
years; 2.7% of patients were less than 20 years,
23.6% were aged between 20 and 29years, 27.3%
were aged between 30 and 39years, 24.5% were aged
between 40 and 49years, 9.1% were aged between
50 and 59years whilst 12.7% were above 60years.
Majority (27.3%) of the patients were in the age
group of 30-39 years. The MCP-1 values ranged from
10 to 2,841, while that of Revised Trauma Score
ranged from 5 to 12. The mean MCP-1 level and
Revised Trauma Score were 284.018 ± 454.074 and
11.245 ± 1.491 respectively. There was no significant
correlation between MCP-1 level and Revised
Trauma Score (r =-0.123, p =0.200).
Conclusion: There is no correlation between serum
levels of Monocyte Chemoattractant Protein-1(MCP-
1) and the severity of injury in polytrauma patients
as assessed by the Revised Trauma Score and thus
serum MCP-1 values may not be an appropriate
marker in predicting outcome.
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