A clinicopathologic analysis of colorectal cancers diagnosed by histology of colonoscopy-derived specimens in Lagos, Nigeria
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چکیده
Introduction: Colorectal cancer (CRC) is one of the
leading causes of cancer-related deaths in Nigeria.
Emerging data indicate there is a gradual increment
in the uptake of colonoscopy as an essential tool in
CRC diagnosis in the country. This article seeks to
document the clinico-pathologic patterns of CRC that
were diagnosed via histology of colonoscopy-derived
samples and highlight differences and relationships
in site-specific disease.
Methods: This was a retrospective study over a
period of five years, carried out in two private medical
centres in Lagos State, Nigeria. Patients who had a
diagnosis of CRC from the histology of colonoscopy
derived tissue samples were included in the study.
The records were then scoured for the demographic,
clinical presentation and pathology data
Results: A total of 84 subjects were included in this
study and there were 47 (56%) males and 37 (44%)
females with a male to female ratio of 1.3:1. The
mean age and standard deviation was 56.6 ± 13.9
years. Thirty seven subjects (44%) were aged 50
years and below. Patients with left-sided disease
constituted the majority 64 (76.2%) in this series and
the most common colonic sub-site was the rectum/
rectosigmoid 35 (41.7%). Bleeding per rectum was
by far the commonest presenting complaint 45
(53.6%) and this was the only symptom that was
significantly associated with left-sided CRC (p=
0.003) while right-sided lesions were associated with
unexplained anemia (p= 0.032) and abdominal pain/
discomfort (p= 0.02). Adenocarcinoma was the most
frequently encountered histological subtype 61
(72.6%).
Conclusion: The study finds that a high proportion
of subjects afflicted with CRC are in the young age
groups. Hematochezia was the most common
presenting complaint and rectal/rectosigmoid the most
common colonic location of CRC lesions. A significant
relationship was found between sidedness and
specific symptoms at presentation.
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