Comparative analysis of Sonographic evaluation of the Spleen between subjects with Hemoglobin SS and AA at the University College Hospital, Ibadan, Nigeria
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چکیده
Introduction: Sickle Cell Anaemia is the most
common genetic disease globally and is due to
replacement of glutamic acid with valine at position
6 of the Beta haemoglobin chain. This study aims to
describe the sonographic findings in the spleen of
patients with sickle cell anaemia and compare same
with those of the controls.
Methodology: A prospective, case-control study
conducted in University College Hospital Ibadan. One
hundred and twenty-eight consenting patients with
HbSS ages 2 to 60 years attending the adult and
children Haematology clinics were recruited while
128 HbAA healthy controls were recruited from the
general outpatient department. Patient’s
demographics, clinical history and ultrasound of the
spleen was performed and documented into the study
proforma.
Results: The mean splenic length in the cases and
controls were statistically significant (5.41 ± 4.28cm
vs 8.96 ± 1.51cm; p = 0.000). The mean splenic length
of SCA patients in the paediatrics age group was
4.43cm and adults was 4.38cm. Normal splenic size
(44.5%) was the most common in this study with
autosplenectomy seen only in 34.4% of all the SCA
patients studied. Abnormal splenic parenchymal
findings were observed in 22 (17.2%) of the cases
with only 4 (3.1%) seen in the control group and this
was statistically significant (p= 0.000).
Conclusion: This study demonstrated the use of
sonography as an invaluable imaging tool in the
assessment of the splenic size as well as its
parenchymal pattern and therefore recommends its
use for sickle cell anaemia patients in crises and / or
follow up.
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نوع مقاله
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